Situating emotional experience

Psychological construction approaches to emotion suggest that emotional experience is situated and dynamic. Fear, for example, is typically studied in a physical danger context (e.g., threatening snake), but in the real world, it often occurs in social contexts, especially those involving social evaluation (e.g., public speaking). Understanding situated emotional experience is critical because adaptive responding is guided by situational context (e.g., inferring the intention of another in a social evaluation situation vs. monitoring the environment in a physical danger situation). In an fMRI study, we assessed situated emotional experience using a newly developed paradigm in which participants vividly imagine different scenarios from a first-person perspective, in this case scenarios involving either social evaluation or physical danger. We hypothesized that distributed neural patterns would underlie immersion in social evaluation and physical danger situations, with shared activity patterns across both situations in multiple sensory modalities and in circuitry involved in integrating salient sensory information, and with unique activity patterns for each situation type in coordinated large-scale networks that reflect situated responding. More specifically, we predicted that networks underlying the social inference and mentalizing involved in responding to a social threat (in regions that make up the “default mode” network) would be reliably more active during social evaluation situations. In contrast, networks underlying the visuospatial attention and action planning involved in responding to a physical threat would be reliably more active during physical danger situations. The results supported these hypotheses. In line with emerging psychological construction approaches, the findings suggest that coordinated brain networks offer a systematic way to interpret the distributed patterns that underlie the diverse situational contexts characterizing emotional life

Primary interoceptive cortex activity during simulated experiences of the body

Studies of the classic exteroceptive sensory systems (e.g., vision, touch) consistently demonstrate that vividly imagining a sensory experience of the world – simulating it – is associated with increased activity in the corresponding primary sensory cortex. We hypothesized, analogously, that simulating internal bodily sensations would be associated with increased neural activity in primary interoceptive cortex. An immersive, language-based mental imagery paradigm was used to test this hypothesis (e.g., imagine your heart pounding during a roller coaster ride, your face drenched in sweat during a workout). During two neuroimaging experiments, participants listened to vividly described situations and imagined “being there” in each scenario. In Study 1, we observed significantly heightened activity in primary interoceptive cortex (of dorsal posterior insula) during imagined experiences involving vivid internal sensations. This effect was specific to interoceptive simulation: it was not observed during a separate affect focus condition in Study 1, nor during an independent Study 2 that did not involve detailed simulation of internal sensations (instead involving simulation of other sensory experiences). These findings underscore the large-scale predictive architecture of the brain and reveal that words can be powerful drivers of bodily experiences

Vacuum switching experiments at California Institute of Technology

Successful experiments in switching or breaking a circuit in a high vacuum have been made at the California Institute of Technology. This paper is a report on three sets of these experiments which extended over a period of three years. The conclusions drawn from the experiments may be summed up in the statement that vacuum breakers of laboratory type have been successful in breaking circuits and offer a possible solution of the circuit-breaker problem. The results show that switching in vacuum affords the advantages of no pitting of contacts, quick break, the arc always going out on the first half cycle, small voltage rise across the switch, and small distance of travel necessary for the switch blades. Making the vacuum switch practical calls for a solution of the problem of making commercial apparatus with vacuum-tight joints, and the elimination of the use of liquid air with the vacuum pump

Different Functional Gene Clusters in Yeast have Different Spatial Distributions of the Transcription Factor Binding Sites

Transcription factors control gene expression by binding to short specific DNA sequences, called transcription factor binding sites (TFBSs), in the promoter of a gene. Thus, studying the spatial distribution of TFBSs in the promoters may provide insights into the molecular mechanisms of gene regulation. I developed a method to construct the spatial distribution of TFBSs for any set of genes of interest. I found that different functional gene clusters have different spatial distributions of TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters. I also found that the binding sites for different transcription factors (TFs) may have different spatial distributions: a sharp peak, a plateau or no dominant single peak. The spatial distributions of binding sites for many TFs derived from my analyses are valuable prior information for TFBS prediction algorithm because different regions of a promoter can assign different possibilities for TFBS occurrence

Vacuum switching experiments at California Institute of Technology

Successful experiments in switching or breaking a circuit in a high vacuum have been made at the California Institute of Technology. This paper is a report on three sets of these experiments which extended over a period of three years. The conclusions drawn from the experiments may be summed up in the statement that vacuum breakers of laboratory type have been successful in breaking circuits and offer a possible solution of the circuit-breaker problem. The results show that switching in vacuum affords the advantages of no pitting of contacts, quick break, the arc always going out on the first half cycle, small voltage rise across the switch, and small distance of travel necessary for the switch blades. Making the vacuum switch practical calls for a solution of the problem of making commercial apparatus with vacuum-tight joints, and the elimination of the use of liquid air with the vacuum pump

New Evidence on Stock Price Effects Associated with Charges in the S&P 500 Index

Since October 1989, Standard and Poor’s has (when possible) announced changes in the composition of the S&P 500 index one week in advance. Because index funds hold S&P 500 stocks to minimize tracking error, index composition changes since this date provide an opportunity to examine the market reaction to an anticipated change in the demand for a stock. Using post-October-1989 data, we document significantly positive (negative) post-announcement abnormal returns that are only partially reversed following additions (deletions). These results indicate the existence of temporary price pressure and downward-sloping log-run demand curves for stocks and represent a violation of market efficiency