173 research outputs found
Micromagnetic simulations of interacting dipoles on a fcc lattice: Application to nanoparticle assemblies
Micromagnetic simulations are used to examine the effects of cubic and axial
anisotropy, magnetostatic interactions and temperature on M-H loops for a
collection of magnetic dipoles on fcc and sc lattices. We employ a simple model
of interacting dipoles that represent single-domain particles in an attempt to
explain recent experimental data on ordered arrays of magnetoferritin
nanoparticles that demonstrate the crucial role of interactions between
particles in a fcc lattice. Significant agreement between the simulation and
experimental results is achieved, and the impact of intra-particle degrees of
freedom and surface effects on thermal fluctuations are investigated.Comment: 10 pages, 9 figure
Chronic Prednisolone Treatment Aggravates Hyperglycemia in Mice Fed a High-Fat Diet but Does Not Worsen Dietary Fat-Induced Insulin Resistance
textabstractSynthetic glucocorticoids such as prednisolone have potent antiinflammatory actions. Unfortunately, these drugs induce severe adverse effects in patients, many of which resemble features of the metabolic syndrome, such as insulin resistance. In this study, we investigated whether adverse effects of prednisolone on glucose homeostasis are aggravated in mice with compromised insulin sensitivity due to a high-fat diet by applying various methods to analyze changes in insulin sensitivity in mice. C57BL/6J micewerefed a high-fat diet for 6wkandtreated with either prednisolone (10 mg/kg · d) or vehicle for the last 7 d. Insulin sensitivity and blood glucose kinetics were analyzed with state-of-the-art stable isotope procedures in different experimental conditions. Prednisolone treatment aggravated fasting hyperglycemia and hyperinsulinemia caused by high-fat feeding, resulting in a higher homeostatic assessment model of insulin resistance. In addition, prednisolone-treated high-fat diet-fed mice appeared less insulin sensitive by detailed analysis of basal glucose kinetics. Remarkably, using hyperinsulinemic-euglycemic or hyperglycemic clamp techniques, neither hepatic nor peripheral insulin resistance was worsened in the group that was treated with prednisolone. Yet analysis of hepatic glucose metabolism revealed that prednisolone did alter glycogen balance by reducing glycogen synthase flux under hyperinsulinemic as well as hyperglycemic conditions. In addition to elevated insulin levels, prednisolone-treated mice showed a major rise in plasma leptin and fibroblast growth factor 21 levels. Our data indicate that prednisoloneinduced adverse effects on glucose metabolism in high-fat diet-fed mice do not reflect impaired insulin sensitivity but may be caused by other changes in the hormonal regulatory network controlling glucose metabolism such as fibroblast growth factor 21 and leptin. Copyrigh
High-temperature ferromagnetism of electrons in narrow impurity bands: Application to CaB
Ferromagnetism with high Curie temperature , well above room
temperature, and very small saturation moment has been reported in various
carbon and boron systems. It is argued that the magnetization must be very
inhomogeneous with only a small fraction of the sample ferromagnetically
ordered. It is shown that a possible source of high within the
ferromagnetic regions is itinerant electrons occupying a narrow impurity band.
Correlation effects do not reduce the effective interaction which enters the
Stoner criterion in the same way as in a bulk band. It is also shown how, in
the impurity band case, spin wave excitations may not be effective in lowering
below its value given by Stoner theory. These ideas are applied to
CaB and a thorough review of the experimental situation in this material is
given. It is suggested that the intrinsic magnetism of the B and O
dimers might be exploited in suitable structures containing these elements.Comment: 26 pages, 2 figure
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