Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia

<p>Abstract</p> <p>Background</p> <p>Post-occlusive hyperemia is often used as a paradigm to evaluate vascular reactivity, for example by measuring post-ischemic flow-mediated dilation, arterial blood flow or temporally resolved venous blood oxygenation (HbO₂). Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO₂in the femoral circulation as part of a single procedure.</p> <p>Methods</p> <p>A multi-echo GRE pulse sequence was designed and implemented to collect velocity-encoded projections in addition to full-image echoes for field mapping as a means to quantify intravascular magnetic susceptibility. The method's feasibility was evaluated at 3T in a small pilot study involving two groups of healthy subjects (mean ages 26 ± 1.6 and 59 ± 7.3 years, N = 7 and 5, respectively) in terms of six parameters characterizing the time-course of reactive hyperemia and their sensitivity to differentiate age effects. The reproducibility was assessed on two of the seven young healthy subjects with three repeated measurements.</p> <p>Results</p> <p>The physiological parameters agree with those obtained with current methods that quantify either velocity or HbO₂alone. Of the six measures of vascular reactivity, one from each group was significantly different in the two subject groups (p < 0.05) even though the study was not powered to detect differences. The mean coefficient of variation (CV) from two subjects undergoing repeat scans were approximately 8% for the oximetric and the arterial velocimetric parameters in the femoral vein and artery, respectively, considerably below intersubject CVs (20 and 35%, for the young and older subject groups, respectively).</p> <p>Conclusion</p> <p>The proposed method is able quantify multiple parameters that may lead to more detailed assessment of peripheral vascular reactivity in a single cuff paradigm rather than in separate procedures as required previously, thereby improving measurement efficiency and patient comfort.</p

Non-triggered quantification of central and peripheral pulse-wave velocity

<p>Abstract</p> <p>Purpose</p> <p>Stiffening of the arteries results in increased pulse-wave velocity (PWV), the propagation velocity of the blood. Elevated aortic PWV has been shown to correlate with aging and atherosclerotic alterations. We extended a previous non-triggered projection-based cardiovascular MR method and demonstrate its feasibility by mapping the PWV of the aortic arch, thoraco-abdominal aorta and iliofemoral arteries in a cohort of healthy adults.</p> <p>Materials and Methods</p> <p>The proposed method "simultaneously" excites and collects a series of velocity-encoded projections at two arterial segments to estimate the wave-front velocity, which inherently probes the high-frequency component of the dynamic vessel wall modulus in response to oscillatory pressure waves. The regional PWVs were quantified in a small pilot study in healthy subjects (N = 10, age range 23 to 68 yrs) at 3T.</p> <p>Results</p> <p>The projection-based method successfully time-resolved regional PWVs for 8-10 cardiac cycles without gating and demonstrated the feasibility of monitoring beat-to-beat changes in PWV resulting from heart rate irregularities. For dul-slice excitation the aliasing was negligible and did not interfere with PWV quantification. The aortic arch and thoracoabdominal aorta PWV were positively correlated with age (p < 0.05), consistent with previous reports. On the other hand, the PWV of the iliofemoral arteries showed decreasing trend with age, which has been associated with the weakening of muscular arteries, a natural aging process.</p> <p>Conclusion</p> <p>The PWV map of the arterial tree from ascending aorta to femoral arteries may provide additional insight into pathophysiology of vascular aging and atherosclerosis.</p

Sesame (Sesamum indicum) Response to Postemergencedirected Herbicide Applications

Field studies were conducted from 2006 to 2010 under weed-free conditions in south Texas and in the Texas High Plains to determine sesame tolerance to applied postemergence-directed herbicides. Injury was greatest when herbicides were applied to 15 cm of the main stem compared to herbicide applications made to 5 cm of the main stem height. Glyphosate at 0.84 kg ae/ha and pyrithiobac-sodium at 0.07 kg ai/ha resulted in the greatest sesame stunting (28–90%) when applied up to 15 cm main stem height, while carfentrazone-ethyl, flumioxazin, and imazethapyr caused greatest injury when applied to 5 cm of the main stem. When glyphosate was applied up to 5 cm main stem height, sesame injury was 20% or less. Glyphosate applied up to the 15 cm stem height and pyrithiobac-sodium applied 5 and 15 cm stem height consistently reduced sesame yield when compared with the nontreated control. Acetochlor, diuron, fluometuron, and prometryn did not cause any sesame stunting. Carfentrazone-ethyl, diuron, flumioxazin, imazethapyr, propazine, pyraflufen-ethyl, linuron, and linuron plus diuron reduced sesame yield in at least one year in south Texas

Sesame ( Sesamum indicum

Studies were conducted during the 2007 and 2008 growing seasons under weed-free conditions in South Texas and the High Plains region of Texas to evaluate preemergence herbicides for sesame tolerance. No reduction in sesame stand was noted with any herbicide at south Texas location; however, at the High Plains location, linuron at the 2X rate reduced stand counts 28 days after treatment (DAT) in 2007 and diuron reduced sesame stand 147 DAT in 2008 when compared with the untreated check. At the 1/2X rate all herbicides exhibited minimal stunting while at the 1X rate stunting was variable and varied between locations. At the 2X rate, all herbicides caused sesame stunting compared to the untreated check. No herbicide, with the exception of linuron at the 2X rate in 2008 at the High Plains location, reduced sesame yield when compared with the untreated check. Although some herbicide treatments resulted in sesame stunting, this did not result in any yield reductions and this can be attributed to the ability of the sesame plant to compensate for injury and/or reduced stands

Proposal for the determination of nuclear masses by high-precision spectroscopy of Rydberg states

The theoretical treatment of Rydberg states in one-electron ions is facilitated by the virtual absence of the nuclear-size correction, and fundamental constants like the Rydberg constant may be in the reach of planned high-precision spectroscopic experiments. The dominant nuclear effect that shifts transition energies among Rydberg states therefore is due to the nuclear mass. As a consequence, spectroscopic measurements of Rydberg transitions can be used in order to precisely deduce nuclear masses. A possible application of this approach to the hydrogen and deuterium, and hydrogen-like lithium and carbon is explored in detail. In order to complete the analysis, numerical and analytic calculations of the quantum electrodynamic (QED) self-energy remainder function for states with principal quantum number n=5,...,8 and with angular momentum L=n-1 and L=n-2 are described (j = L +/- 1/2).Comment: 21 pages; LaTe