UWB human detection radar system: A RF CMOS chip and algorithm integrated sensor

This paper presents a radio frequency (RF) CMOS chip and algorithm integrated solution of an Ultra-Wideband (UWB) Impulse-Radio (IR) radar system for human presence detection and tracking. UWB radar can complement other human detection and tracking technologies, as it works well in poor visibility conditions with high time/depth-resolution. UWB radar response provides the complex multipath scattering characteristics in each scan, as well as the high sensitive variation in dynamic observation patterns between scans to pose challenge in designing UWB radar hardware and signal processing algorithm. We develop a UWB IR CMOS human feature detection radar transceiver chip and human presence detection algorithm. Thereafter, we integrated the UWB CMOS radar chip and the algorithm through UWB sensor module, and tested the integrated system in a simple outdoor environment to validate the performance of the integrated system. We present experimental results in which the integrated UWB human detection radar system tracks human and non-human targets, and detects human presence by discerning human from moving non-human objects robustly using human feature extraction and likelihood ratio testing (LRT)

Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo

Mice engrafted with human CD34+ hematopoietic stem and progenitor cells (CD34+ -HSPCs) have been used to study human infection, diabetes, sepsis, and burn, suggesting that they could be highly amenable to characterizing the human inflammatory response to injury. To this end, human leukocytes infiltrating subcutaneous implants of polyvinyl alcohol (PVA) sponges were analyzed in immunodeficient NSG mice reconstituted with CD34+ -HSPCs. It was reported that human CD45+ (hCD45+ ) leukocytes were present in PVA sponges 3 and 7 days postimplantation and could be localized within the sponges by immunohistochemistry. The different CD45+ subtypes were characterized by flow cytometry and the profile of human cytokines they secreted into PVA wound fluid was assessed using a human-specific multiplex bead analyses of human IL-12p70, TNFα, IL-10, IL-6, IL1β, and IL-8. This enabled tracking the functional contributions of HLA-DR+ , CD33+ , CD19+ , CD62L+ , CD11b+ , or CX3CR1+ hCD45+ infiltrating inflammatory leukocytes. PCR of cDNA prepared from these cells enabled the assessment and differentiation of human, mouse, and uniquely human genes. These findings support the hypothesis that mice engrafted with CD34+ -HSPCs can be deployed as precision avatars to study the human inflammatory response to injury