5,585 research outputs found
Scattering from a Domain Wall in a Spontaneously Broken Gauge Theory
We study the interaction of particles with a domain wall at a
symmetry-breaking phase transition by perturbing about the domain wall
solution. We find the particulate excitations appropriate near the domain wall
and relate them to the particles present far from the wall in the uniform
broken and unbroken phases. For a quartic Higgs potential we find analytic
solutions to the equations of motion and derive reflection and transmission
coefficients. We discover several bound states for particles near the wall.
Finally, we apply our results to the electroweak phase transition in the
standard model.Comment: 48 pages, 10 figures, LaTeX / epsf, revised to include references to
earlier related wor
Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game
BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironment, effect tumour progression and represent a largely under appreciated therapeutic target. We use observations of primary tumor biology from prostate cancer to extrapolate a mathematical model: specifically; it has been observed that in prostate cancer three disparate cellular outcomes predominate: (i) the tumour remains well differentiated and clinically indolent - in this case the local stromal cells may act to restrain the growth of the cancer; (ii) early in its genesis the tumour acquires a highly malignant phenotype, growing rapidly and displacing the original stromal population (often referred to as small cell prostate cancer) - these less common aggressive tumours are relatively independent of the local microenvironment; and, (iii) the tumour co-opts the local stroma - taking on a classic stromagenic phenotype where interactions with the local microenvironment are critical to the cancer growth. METHODS: We present an evolutionary game theoretical construct that models the influence of tumour-stroma interactions in driving these outcomes. We consider three characteristic and distinct cellular populations: stromal cells, tumour cells that are self-reliant in terms of microenvironmental factors and tumour cells that depend on the environment for resources but can also co-opt stroma. 
RESULTS: Using evolutionary game theory we explore a number of different scenarios that elucidate the impact of tumour-stromal interactions on the dynamics of prostate cancer growth and progression and how different treatments in the metastatic setting can affect different types of tumors.
CONCLUSIONS: The tumour microenvironment plays a crucial role selecting the traits of the tumour cells that will determine prostate cancer progression. Equally important, treatments like hormone therapy affect the selection of these cancer phenotypes making it very important to understand how they impact prostate cancer’s somatic evolution
A Catalog of Cool Dwarf Targets for the Transiting Exoplanet Survey Satellite
We present a catalog of cool dwarf targets (, ) and their stellar properties for the upcoming Transiting Exoplanet
Survey Satellite (TESS), for the purpose of determining which cool dwarfs
should be observed using two-minute observations. TESS has the opportunity to
search tens of thousands of nearby, cool, late K and M-type dwarfs for
transiting exoplanets, an order of magnitude more than current or previous
transiting exoplanet surveys, such as {\it Kepler}, K2 and ground-based
programs. This necessitates a new approach to choosing cool dwarf targets. Cool
dwarfs were chosen by collating parallax and proper motion catalogs from the
literature and subjecting them to a variety of selection criteria. We calculate
stellar parameters and TESS magnitudes using the best possible relations from
the literature while maintaining uniformity of methods for the sake of
reproducibility. We estimate the expected planet yield from TESS observations
using statistical results from the Kepler Mission, and use these results to
choose the best targets for two-minute observations, optimizing for small
planets for which masses can conceivably be measured using follow up Doppler
spectroscopy by current and future Doppler spectrometers. The catalog is
incorporated into the TESS Input Catalog and TESS Candidate Target List until a
more complete and accurate cool dwarf catalog identified by ESA's Gaia Mission
can be incorporated.Comment: Accepted to The Astronomical Journal. For the full catalog, please
contact the corresponding autho
Chiral and Parity Symmetry Breaking for Planar Fermions: Effects of a Heat Bath and Uniform External Magnetic Field
We study chiral symmetry breaking for relativistic fermions, described by a
parity violating Lagrangian in 2+1-dimensions, in the presence of a heat bath
and a uniform external magnetic field. Working within their four-component
formalism allows for the inclusion of both parity-even and -odd mass terms.
Therefore, we can define two types of fermion anti-fermion condensates. For a
given value of the magnetic field, there exist two different critical
temperatures which would render one of these condensates identically zero,
while the other would survive. Our analysis is completely general: it requires
no particular simplifying hierarchy among the energy scales involved, namely,
bare masses, field strength and temperature. However, we do reproduce some
earlier results, obtained or anticipated in literature, corresponding to
special kinematical regimes for the parity conserving case. Relating the chiral
condensate to the one-loop effective Lagrangian, we also obtain the
magnetization and the pair production rate for different fermion species in a
uniform electric field through the replacement .Comment: 9 pages, 10 figure
Spin-phonon coupling in Gd(Co1/2Mn1/2)O3 perovskite
We have investigated the temperature-dependent Raman-active phonons and the
magnetic properties of Gd(Co1/2Mn1/2)O3 perovskite ceramics in the temperature
range from 40 K to 300 K. The samples crystallized in an orthorhombic distorted
simple perovskite, whose symmetry belongs to the Pnma space group. The data
reveals spin-phonon coupling near the ferromagnetic transition occurring at
around 120 K. The correlation of the Raman and magnetization data suggests that
the structural order influences the magnitude of the spin-phonon coupling.Comment: 3 Figures, suplementary materia
Effects of Gravity on the Acceleration and Pair Statistics of Inertial Particles in Homogeneous Isotropic Turbulence
Within the context of heavy particles suspended in a turbulent airflow, we study the effects of gravity on acceleration statistics and radial relative velocity (RRV) of inertial particles. The turbulent flow is simulated by direct numerical simulation (DNS) on a 2563 grid and the dynamics of O(106) inertial particles by the point-particle approach. For particles/droplets with radius from 10 to 60 µm, we found that the gravity plays an important role in particle acceleration statistics: (a) a peak value of particle acceleration variance appears in both the horizontal and vertical directions at a particle Stokes number of about 1.2, at which the particle horizontal acceleration clearly exceeds the fluid-element acceleration; (b) gravity constantly disrupts quasi-equilibrium of a droplet\u27s response to local turbulent motion and amplifies extreme acceleration events both in the vertical and horizontal directions and thus effectively reduces the inertial filtering mechanism. By decomposing the RRV of the particles into three parts: (1) differential sedimentation, (2) local flow shear, and (3) particle differential acceleration, we evaluate and compare their separate contributions. For monodisperse particles, we show that the presence of gravity does not have a significant effect on the shear term. On the other hand, gravity suppresses the probability distribution function (pdf) tails of the differential acceleration term due to a lower particle-eddy interaction time in presence of gravity. For bidisperse cases, we find that gravity can decrease the shear term slightly by dispersing particles into vortices where fluid shear is relatively low. The differential acceleration term is found to be positively correlated with the gravity term, and this correlation is stronger when the difference in colliding particle radii becomes smaller. Finally, a theory is developed to explain the effects of gravity and turbulence on the horizontal and vertical acceleration variances of inertial particles at small Stokes numbers, showing analytically that gravity affects particle acceleration variance both in horizontal and vertical directions, resulting in an increase in particle acceleration variance in both directions. Furthermore, the effect of gravity on the horizontal acceleration variance is predicted to be stronger than that in the vertical direction, in agreement with our DNS results. © 2015 AIP Publishing LLC
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