851 research outputs found
Cohort Profile: The Mater-University of Queensland Study of Pregnancy (MUSP)
How did the study come about? At the initiative of three hospital-based obstetricians one of the authors (JMN) and another sociologist attended a 1978 meeting to explore the potential for collaborative research. No specific project was proposed by the obstetricians. Two of the obstetricians had been trained in Scotland; one in Aberdeen where he had had some familiarity with the work of obstetrician Dugald Baird and sociologist Raymond Illsely. The obstetricians argued for an agenda which was clinically oriented. The two sociologists were more focussed on understanding how some social constructs (e.g. social class) might be relevant to explaining health outcomes. The initial year of the study was characterised by frequent (at least weekly) meetings at which the aims and substance of the proposed study were debated vigorously. As an initial decision the team focused on factors associated with adverse pregnancy outcomes. The first major project was to be a 3-5 year longitudinal study of pregnant women which would include a 6-month child post-natal follow-up as the main outcome of interest
The X-ray luminosity function of AGN at z~3
We combine Lyman-break colour selection with ultradeep (> 200 ks) Chandra
X-ray imaging over a survey area of ~0.35 deg^2 to select high redshift AGN.
Applying careful corrections for both the optical and X-ray selection
functions, the data allow us to make the most accurate determination to date of
the faint end of the X-ray luminosity function (XLF) at z~3. Our methodology
recovers a number density of X-ray sources at this redshift which is at least
as high as previous surveys, demonstrating that it is an effective way of
selecting high z AGN. Comparing to results at z=1, we find no evidence that the
faint slope of the XLF flattens at high z, but we do find significant (factor
~3.6) negative evolution of the space density of low luminosity AGN. Combining
with bright end data from very wide surveys we also see marginal evidence for
continued positive evolution of the characteristic break luminosity L*. Our
data therefore support models of luminosity-dependent density evolution between
z=1 and z=3. A sharp upturn in the the XLF is seen at the very lowest
luminosities (Lx < 10^42.5 erg s^-1), most likely due to the contribution of
pure X-ray starburst galaxies at very faint fluxes.Comment: 16 pages, 9 figures, accepted for publication in MNRA
The X-ray luminosity function of Active Galactic Nuclei in the redshift interval z=3-5
We combine deep X-ray survey data from the Chandra observatory and the
wide-area/shallow XMM-XXL field to estimate the AGN X-ray luminosity function
in the redshift range z=3-5. The sample consists of nearly 340 sources with
either photometric (212) or spectroscopic (128) redshift in the above range.
The combination of deep and shallow survey fields provides a luminosity
baseline of three orders of magnitude, Lx(2-10keV)~1e43-1e46erg/s at z>3. We
follow a Bayesian approach to determine the binned AGN space density and
explore their evolution in a model-independent way. Our methodology accounts
for Poisson errors in the determination of X-ray fluxes and uncertainties in
photometric redshift estimates. We demonstrate that the latter is essential for
unbiased measurement of space densities. We find that the AGN X-ray luminosity
function evolves strongly between the redshift intervals z=3-4 and z=4-5. There
is also suggestive evidence that the amplitude of this evolution is luminosity
dependent. The space density of AGN with Lx<1e45erg/s drops by a factor of 5
between the redshift intervals above, while the evolution of brighter AGN
appears to be milder. Comparison of our X-ray luminosity function with that of
UV/optical selected QSOs at similar redshifts shows broad agreement at bright
luminosities, Lx>1e45erg/s. The faint-end slope of UV/optical luminosity
functions however, is steeper than for X-ray selected AGN. This implies that
the type-I AGN fraction increases with decreasing luminosity at z>3, opposite
to trends established at lower redshift. We also assess the significance of AGN
in keeping the hydrogen ionised at high redshift. Our X-ray luminosity function
yields ionising photon rate densities that are insufficient to keep the
Universe ionised at redshift z>4. A source of uncertainty in this calculation
is the escape fraction of UV photons for X-ray selected AGN.Comment: MNRAS accepte
Functional Vascular Endothelium Derived from Human Induced Pluripotent Stem Cells
Summary Vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. Human genotype-phenotype studies of endothelium are limited by the unavailability of patient-specific endothelial cells. To establish a cellular platform for studying endothelial biology, we have generated vascular endothelium from human induced pluripotent stem cells (iPSCs) exhibiting the rich functional phenotypic plasticity of mature primary vascular endothelium. These endothelial cells respond to diverse proinflammatory stimuli, adopting an activated phenotype including leukocyte adhesion molecule expression, cytokine production, and support for leukocyte transmigration. They maintain dynamic barrier properties responsive to multiple vascular permeability factors. Importantly, biomechanical or pharmacological stimuli can induce pathophysiologically relevant atheroprotective or atheroprone phenotypes. Our results demonstrate that iPSC-derived endothelium possesses a repertoire of functional phenotypic plasticity and is amenable to cell-based assays probing endothelial contributions to inflammatory and cardiovascular diseases
The NuSTAR Extragalactic Survey: First Direct Measurements of the Greater Than Or Similar To 10 Kev X-Ray Luminosity Function For Active Galactic Nuclei At z \u3e 0.1
We present the first direct measurements of the rest-frame 10–40 keV X-ray luminosity function (XLF) of active galactic nuclei (AGNs) based on a sample of 94 sources at 0.1 \u3c z \u3c 3, selected at 8–24 keV energies from sources in the Nuclear Spectroscopic Telescope Array (NuSTAR) extragalactic survey program. Our results are consistent with the strong evolution of the AGN population seen in prior, lower-energy studies of the XLF. However, different models of the intrinsic distribution of absorption, which are used to correct for selection biases, give significantly different predictions for the total number of sources in our sample, leading to small, systematic differences in our binned estimates of the XLF. Adopting a model with a lower intrinsic fraction of Compton-thick sources and a larger population of sources with column densities cm−2 or a model with stronger Compton reflection component (with a relative normalization of R ~ 2 at all luminosities) can bring extrapolations of the XLF from 2–10 keV into agreement with our NuSTAR sample. Ultimately, X-ray spectral analysis of the NuSTAR sources is required to break this degeneracy between the distribution of absorbing column densities and the strength of the Compton reflection component and thus refine our measurements of the XLF. Furthermore, the models that successfully describe the high-redshift population seen by NuSTAR tend to over-predict previous, high-energy measurements of the local XLF, indicating that there is evolution of the AGN population that is not fully captured by the current models
The 10 Meter South Pole Telescope
The South Pole Telescope (SPT) is a 10 m diameter, wide-field, offset
Gregorian telescope with a 966-pixel, multi-color, millimeter-wave, bolometer
camera. It is located at the Amundsen-Scott South Pole station in Antarctica.
The design of the SPT emphasizes careful control of spillover and scattering,
to minimize noise and false signals due to ground pickup. The key initial
project is a large-area survey at wavelengths of 3, 2 and 1.3 mm, to detect
clusters of galaxies via the Sunyaev-Zeldovich effect and to measure the
small-scale angular power spectrum of the cosmic microwave background (CMB).
The data will be used to characterize the primordial matter power spectrum and
to place constraints on the equation of state of dark energy. A
second-generation camera will measure the polarization of the CMB, potentially
leading to constraints on the neutrino mass and the energy scale of inflation.Comment: 47 pages, 14 figures, updated to match version to be published in
PASP 123 903 (May, 2011
Theory of Coexistence of Superconductivity and Ferroelectricity : A Dynamical Symmetry Model
We propose and investigate a model for the coexistence of Superconductivity
(SC) and Ferroelectricity (FE) based on the dynamical symmetries for
the pseudo-spin SC sector, for the displaced oscillator FE sector, and
for the composite system. We assume a minimal
symmetry-allowed coupling, and simplify the hamiltonian using a double mean
field approximation (DMFA). A variational coherent state (VCS) trial
wave-function is used for the ground state: the energy, and the relevant order
parameters for SC and FE are obtained. For positive sign of the SC-FE coupling
coefficient, a non-zero value of either order parameter can suppress the other
(FE polarization suppresses SC and vice versa). This gives some support to
"Matthias' Conjecture" [1964], that SC and FE tend to be mutually exclusive.
For such a Ferroelectric Superconductor we predict: a) the SC gap
(and ) will increase with increasing applied pressure when pressure
quenches FE as in many ferroelectrics, and b) the FE polarization will increase
with increaesing magnetic field up to . The last result is equivalent to
the prediction of a new type of Magneto-Electric Effect in a coexistent SC-FE
material. Some discussion will be given of the relation of these results to the
cuprate superconductors.Comment: 46 page
Performance and on-sky optical characterization of the SPTpol instrument
In January 2012, the 10m South Pole Telescope (SPT) was equipped with a
polarization-sensitive camera, SPTpol, in order to measure the polarization
anisotropy of the cosmic microwave background (CMB). Measurements of the
polarization of the CMB at small angular scales (~several arcminutes) can
detect the gravitational lensing of the CMB by large scale structure and
constrain the sum of the neutrino masses. At large angular scales (~few
degrees) CMB measurements can constrain the energy scale of Inflation. SPTpol
is a two-color mm-wave camera that consists of 180 polarimeters at 90 GHz and
588 polarimeters at 150 GHz, with each polarimeter consisting of a dual
transition edge sensor (TES) bolometers. The full complement of 150 GHz
detectors consists of 7 arrays of 84 ortho-mode transducers (OMTs) that are
stripline coupled to two TES detectors per OMT, developed by the TRUCE
collaboration and fabricated at NIST. Each 90 GHz pixel consists of two
antenna-coupled absorbers coupled to two TES detectors, developed with Argonne
National Labs. The 1536 total detectors are read out with digital
frequency-domain multiplexing (DfMUX). The SPTpol deployment represents the
first on-sky tests of both of these detector technologies, and is one of the
first deployed instruments using DfMUX readout technology. We present the
details of the design, commissioning, deployment, on-sky optical
characterization and detector performance of the complete SPTpol focal plane.Comment: 15 pages, 6 figures. Conference: SPIE Astronomical Telescopes and
Instrumentation 201
Design and characterization of 90 GHz feedhorn-coupled TES polarimeter pixels in the SPTpol camera
The SPTpol camera is a two-color, polarization-sensitive bolometer receiver,
and was installed on the 10 meter South Pole Telescope in January 2012. SPTpol
is designed to study the faint polarization signals in the Cosmic Microwave
Background, with two primary scientific goals. One is to constrain the
tensor-to-scalar ratio of perturbations in the primordial plasma, and thus
constrain the space of permissible inflationary models. The other is to measure
the weak lensing effect of large-scale structure on CMB polarization, which can
be used to constrain the sum of neutrino masses as well as other growth-related
parameters. The SPTpol focal plane consists of seven 84-element monolithic
arrays of 150 GHz pixels (588 total) and 180 individual 90 GHz single-pixel
modules. In this paper we present the design and characterization of the 90 GHz
modules
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