GAS CHROMATOGRAPH-MASS SPECTROMETER ANALYSIS AND ACUTE ORAL TOXICITY OF CINNAMOMUM BURMANNII., NESS EX BL. ESSENTIAL OIL

ABSTRACTObjective: Cinnamomum burmannii Nees Ex Bl. essential oil has cytotoxic effect on a lot of cancer cell lines. An investigation was carried out to analyzethe possible chemical components from C. burmannii essential oil and evaluate its acute toxicity, before an effective formulation of C. burmanniiessential oil as anticancer drugs.Methods: This study was analyzed chemical components from C. burmannii essential oil by gas chromatograph-mass spectrometer (GC-MS) andevaluated the acute oral toxicities of C. burmannii essential oil in strain Balb/C mice. Results: This analysis revealed that C. burmannii essential oil contains the active compound cinnamaldehyde (71.814%), trans-cinnamyl acetate(11.09%), coumarin (3.41%), and cineol (1.77%). Acute oral toxicity of C. burmannii essential oil with lethal dose 50 3679.11 mg/kg BW.Conclusion: C. burmannii essential oil contains the active compound cinnamaldehyde, trans-cinnamyl acetate, coumarin and cineol. Acute oral toxicityconclusively indicates C. burmannii essential oil includes category 5 practically non-toxic.Keywords: Gas chromatograph-mass spectrometer, Cinnamomum burmannii, Essential oil, Acute toxicity

A REVIEW OF CINNAMON AS A POTENT ANTICANCER DRUG

ABSTRACTCinnamon is one of the most popular and oldest spices. Several recent studies have found that cinnamon also has anticancer activity. The present workhas reported the antineoplastic potential of the spice cinnamon in cancer. Collectively, these data suggest that cinnamon could be proposed as a potentanticancer drug. The bibliographic investigation was carried out during January 2004-December 2014 by analyzing journals and peer-reviewedpapers from the last decades. Peer-reviewed articles were indexed by Scopus, PubMed, and Google scholar. Only relevant studies published in Englishwere considered. There were 24 articles that reported the cytotoxic activity of cinnamon on all culture cell lines. About 8 species of Cinnamomum havebeen isolated with their active compounds for cancer cell lines. Based on the reviews of those articles, we conclude that cinnamon has the potentialto be further developed as an anticancer agent. In further development, however, not only the research for investigating the anticancer activities, butalso research for investigating the safety of cinnamon to the normal cell need to be performed.Keywords: Review, Cinnamon, Anticancer, Cinnamomum species, Cell lines