ABSTRACTObjective: Cinnamomum burmannii Nees Ex Bl. essential oil has cytotoxic effect on a lot of cancer cell lines. An investigation was carried out to analyzethe possible chemical components from C. burmannii essential oil and evaluate its acute toxicity, before an effective formulation of C. burmanniiessential oil as anticancer drugs.Methods: This study was analyzed chemical components from C. burmannii essential oil by gas chromatograph-mass spectrometer (GC-MS) andevaluated the acute oral toxicities of C. burmannii essential oil in strain Balb/C mice. Results: This analysis revealed that C. burmannii essential oil contains the active compound cinnamaldehyde (71.814%), trans-cinnamyl acetate(11.09%), coumarin (3.41%), and cineol (1.77%). Acute oral toxicity of C. burmannii essential oil with lethal dose 50 3679.11 mg/kg BW.Conclusion: C. burmannii essential oil contains the active compound cinnamaldehyde, trans-cinnamyl acetate, coumarin and cineol. Acute oral toxicityconclusively indicates C. burmannii essential oil includes category 5 practically non-toxic.Keywords: Gas chromatograph-mass spectrometer, Cinnamomum burmannii, Essential oil, Acute toxicity
