Changes in resting membrane potential and contractility of innervated and denervated skeletal muscle free grafts in the rat

In free orthotopic auto-grafts of the extensor digitorum muscle of rats a marked temporary decrease of resting membrane potential (RMP) of two superficial layers of muscle fibres is observed at 2 days with subsequent recovery 4 days after transplantation. Such a temporary decrease of the RMP is not observed in grafts of denervated muscle. This difference in change of RMP is apparently related to a temporary marked decrease or loss of contractility observed in innervated but not denervated graft and may explain in part the relatively more successful grafting of denervated muscles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47442/1/424_2004_Article_BF00586551.pd

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PRocH: Proof Reconstruction for HOL Light

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