1 research outputs found
One-Pot, Three-Component Synthesis of 7-Azaindole Derivatives from N-Substituted 2-Amino-4-cyanopyrroles, Various Aldehydes, and Active Methylene Compounds
An efficient and practical route to 7-azaindole framework
has been
developed by one-pot, three-component cyclocondensation of N-substituted
2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds
in ethanol or acetic acid at reflux. Reactions involving tetronic
acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione
gave carbocyclic fused 7-azaindoles, whereas Meldrum’s acid,
benzoylacetonitrile, and malononitrile resulted in the highly substituted
7-azaindole derivatives, making this strategy very useful in diversity-oriented
synthesis (DOS)