26 research outputs found
Clusters as a Part of Improvement Function of Serbian Economy Real Sector Competitiveness
One of the reasons for the lack of small and medium enterprises’ competitiveness and for large regional disproportions in Serbia is the underdeveloped system of business connectivity that includes clusters, business incubators and technology parks. Setting competitiveness in the centre of the development strategy requires of all businesses subjects new approach development which will allow a better use of existing resources and result in increased export performances. Supporting association into clusters and using their benefits according to the model of highly developed countries is the basis of successful management of economic policy, and all the necessary prerequisites exist in Serbia
The investment policy and regional development of Serbia in the transition period
Our country can compensate the lagging in the economic development in relation to the EU countries as well as to the countries of the region only by increasing the economy's competitiveness, depending to a great extent on the possibilities of the economic entities investment in improving the attributes of the existing and development of new products and services, as well as on introducing modern technology and technological procedures. The transition program conducted by former socialist countries was highly based on foreign direct investments (FDI) enabling these countries the successful inclusion into global flows of international production and overall economy. In this paper the possibilities and sources of our economy investing will be analyzed and the influence on enhancement of the overall and regional competitiveness of the companies as a necessary condition for increasing the export and the overall economic development of the country
Impact of economic policy on the management of competitiveness of the agriculture sector in Serbia
There is a tendency of increase and change in the structure of demand for the products from agricultural sector in the modern global environment. Such situation demands market orientation of agricultural producers, from business entities to individual agricultural holdings, in order to offer the appropriate response to the changes in the environment conditions and new market demands. The entrance and survival in the developed world market demand raising the competitiveness of agricultural sector which cannot be based on the low input prices alone (land, workforce), but the application of modern knowledge and innovation, that is, the synergistic effect of all the competition factors. For their part, the state and local governments should create an encouraging social and economic environment for agriculture and rural development, especially in undeveloped regions and areas of the Republic of Serbia. The undeniable agricultural potentials can significantly contribute to foreign trade balance improvement, public debt reduction, unemployment decrease and increase of the living standard of the population
Improvement of business decision-making in the IT industry using the MCDM approach
The selection of suitable individuals for critical roles within the organization can significantly affect the business efficiency and performance of the organization. For this reason, this article presents a multiple-criteria decision-making procedure for candidates' assessment in the Information Technologies industry (IT) using the integrated PIPRECIA-S and WS-PLP methods. The introduced approach involved defining the criteria' significance with the help of the PIPRECIA-S, while the WS-PLP method was used to evaluate candidates and harmonize the views of decision-makers attitudes. The applicability of the suggested technique was reviewed in the situation of selecting an IT Project Manager in an IT company. However, it can easily be adapted for similar cases of candidate selection
Antioxidant activity of pea protein hydrolysates produced by batch fermentation with lactic acid bacteria
Nine Lactobacillus strains known for surface proteinase activity were chosen from our collection and tested for their ability to grow in pea seed protein-based medium, and to hydrolyze purified pea proteins in order to produce peptides with antioxidant (AO) activity. Two strains, Lactobacillus rhamnosus BGT10 and Lactobacillus zeae LMG17315, exhibited strong proteolytic activity against pea proteins. The AO activity of the pea hydrolysate fraction, MW lt 10 kDa, obtained by the fermentation of purified pea proteins with Lactobacillus rhamnosus BGT10, was tested by standard spectrophotometric assays (DPPH, ABTS, Fe3+-reducing capacity) and the recently developed direct current (DC) polarographic assay. The low molecular weight fraction of the obtained hydrolysate was separated using ion exchange chromatography, while the AO activity of eluted fractions was determined by means of a sensitive DC polarographic assay without previous concentration of samples. Results revealed that the fraction present in low abundance that contained basic peptides possessed the highest antioxidant activity. Based on the obtained results, it can be concluded that Lactobacillus rhamnosus BGT10 should be further investigated as a candidate strain for large-scale production of bioactive peptides from legume proteins
Application of different Lactobacillus strains in production pea seed protein hydrolysates with antioxidative activity
In recent years antioxidant properties of plant derived protein hydrolysates were established. Antioxidative activity of these hydrolysates largely depends on specificity of the proteinase used for hydrolysis, duration of proteinase treatment, as well as composition and molecular weight of hydrolysis derived peptides. In order to explore potential use of nine proteinase containing Lactobacillus strains in production of antioxidative peptides we tested their ability to hydrolyze lyophilized hydrosoluble protein fraction from dehulled and defatted dry pea seeds (Pisum sativum), cultivar NS Mraz. We also developed plant protein based liquid medium for cultivation of lactobacilli which was later used as starter for hydrolysis reaction in larger volume. We found that all nine strains could hydrolyze plant hydrosoluble fraction of pea seed proteins but with different efficiency. We also examined the effect of duration of hydrolysis on antioxidative activity in <10kDa fraction of obtained peptide extracts, using most proteolyticaly active strain, human vaginal isolate Lactobacillus rhamnosus T10. General conclusion was that antioxidative activity was positively correlated with increase of hydrolysis duration and amount of small peptides, which reached up to 34% of total proteins after 24h of hydrolysis treatment
Antioxidant Activity of Pea Protein Hydrolysates Produced by Batch Fermentation with Lactic Acid Bacteria
Nine Lactobacillus strains known for surface proteinase activity were chosen from our collection and tested for their ability to grow in pea seed protein-based medium, and to hydrolyze purified pea proteins in order to produce peptides with antioxidant (AO) activity. Two strains, Lactobacillus rhamnosus BGT10 and Lactobacillus zeae LMG17315, exhibited strong proteolytic activity against pea proteins. The AO activity of the pea hydrolysate fraction, MW lt 10 kDa, obtained by the fermentation of purified pea proteins with Lactobacillus rhamnosus BGT10, was tested by standard spectrophotometric assays (DPPH, ABTS, Fe3+-reducing capacity) and the recently developed direct current (DC) polarographic assay. The low molecular weight fraction of the obtained hydrolysate was separated using ion exchange chromatography, while the AO activity of eluted fractions was determined by means of a sensitive DC polarographic assay without previous concentration of samples. Results revealed that the fraction present in low abundance that contained basic peptides possessed the highest antioxidant activity. Based on the obtained results, it can be concluded that Lactobacillus rhamnosus BGT10 should be further investigated as a candidate strain for large-scale production of bioactive peptides from legume proteins
Национална економија
Serbian. У овом одељку разматрају се опште карактеристике националне економије. У првом делу приказан је њен историјски развој, који је обухватио привреду у средњовековној српској држави Немањића, преко развоја у оквирима турске феудалне државе, изградње самосталне српске државе након српских устанака и ослобођења од Турске, па до развоја у савременим условима 20. и 21. века. Тај вишевековни развој протицао је у сталним напорима да се превазиђе наслеђена економска заосталост, да се унапреди и модернизује привреда, односно да се претежно аграрна земља претвори у земљу с модерном индустријском привредом, али и уз отпоре изражене у супротној тенденцији да се одржи аграрни, односно сељачки карактер земље. Ипак, био је то процес који се уз мање или више осцилација, али у целини успешно одвијао све до пред крај 20. века. Међутим, почев од последње деценије претходног века земља је током процеса транзиције била деиндустријализована, тако да је сада на нивоу развоја од пре неколико деценија, и стоји пред поновним захтевима за (ре)индустријализацијом. У другом делу разматрају се актуелне карактеристике привреде Србије, подељене у четири сектора.
English. In this chapter the main characteristics of the national economy will be considered. In the first part there is explored its historical development. It involves the economy of the middle century Nemanjićs’ Serbian state, through the development in the framework of Turkish feudal state, the building of independent Serbian state after the Serbian uprisings and liberation from Turkey, up to development in modern circumstances of 20th and 21st centuries. This many centuries development characterize constant efforts to overcome the inherited economic backwardness, to move up and modernize the economy, i.e. to transform the predominantly agrarian state to the state with modern manufacturing economy, but also with resistances represented in opposite tendency to keep agrarian, i.e. peasant character of the state. Although, it was the process, that successfully carried out until to last decade of 20th century. But, since this decade the state was deindustrialized through the transition process, so it is now on the level of some decade before, and state is confronted with the repeated need for reindustrialization. In the second part of this chapter the actual characteristics of the Serbian economy are considered, divided in four sectors
THE USE OF INTEGRATIVE MULTI-OMICS APPROACH IN CULTIVATION AND CHARACTERIZATION OF GUT BACTERIA RELATED TO MICROBIOTA-GUT-BRAIN AXIS AS A SOURCE FOR NEXT GENERATION PROBIOTICS
There has been an epidemic of various non-communicable
degenerative and autoimmune diseases,
strongly associated with the modern
lifestyle. Among them, neurodegenerative and
psychiatric disorders represent a huge burden on
society. Recently, all these diseases have been associated
with the gut microbiota dysbiosis. Gut
microbiota-host interaction research has been
greatly improved due to development of molecular
high-throughput techniques based on
various ‘omics’ techniques coupled with bioinformatics
and data science developments. However,
the mechanisms of the host–microbiota crosstalk
are still poorly understood. The NextGenBiotics
project proposes an innovative integrative
multi-omics research strategy for deciphering
the mechanism behind the cross-talk among
microbiota and gut-brain-axis. The 118 novel
NGPs candidates belonging to Dorea sp., Blautia
sp., Bacteroides sp., Roseburia sp., Sellimonas
sp., Faecalicatena sp., Phascolarctobacterium faecium,
and Faecalimonas sp. were cultivated. The
25 NGPs with confirmed safe status and potential
probiotic potential were screened in C. elegans
model for their effects on behavioural and neuronal
activity. The most prominent candidates
with ability to upregulate expression of genes
involved in neurotransmiting are further tested
in EAE (an animal model for MS) and CUMS depression
model. The specific microbiota-derived
metabolites have been identified as potential
neuro- and psycho-biotics. The NextGenBiotics is
highly ambitious project, dedicated to pioneering
work in the field of multi-omics studies related
to the cultivation of novel anaerobic NGPs
and the studying of their effect on MGBA. This
concept enabled studying bidirectional communication
between gut microbiota and brain
on the functional level that will significantly
contribute to the growing body data related to
MGBA. The results obtained during NextGenBiotics
determined the genes/metabolites and the
associated mechanisms involved in health-promoting
effects of NGPs in MGBA beyond stateof-
the-art, broadening the scientific knowledge
and opening up the possible novel therapeutic
approaches in prevention and therapy of neurodegenerative
and psychiatric diseases.Book of abstract: From biotechnology to human and planetary health XIII congress of microbiologists of Serbia with international participation Mikromed regio 5, ums series 24: 4th – 6th april 2024, Mona Plaza hotel, Belgrade, Serbi