Otpadne vode Topole

In this paper we can see the basic characteristics and the quality of wastewater of Topola before and after the process of purification. Only households and catering Facilities are connected to the town's sewage network, so that at treatment of wastewater, only mechanical and biological procedures of purification are applied. The central place at the Plant for waste water purification is bioaeration pool, where microbiological degradation reduces the presence of organic pollution.The significant reduction of values of basic organic pollution indicators BOD5 (81,84%) and COD (82,27%) in wastewater after the purification process confirm the efficiency and justification of the applied technological process.U radu su prikazane osnovne karakteristike i kvalitet otpadnih (kanalizacionih) voda Topole pre i posle procesa prešićavanja. Na gradsku kanalizacionu mrežu Topole su priključena isključivo domaćinstva i ugostiteljski objekti, tako da su u tretmanu otpadnih voda primenjeni postupci mehaničkog i biološkog prečišćavanja. Centralno mesto u Postrojenju za prečišćavanje otpadnih voda zauzima bioaeracioni bazen u kome se mikrobiološkom razgradnjom smanjuje prisutno organsko zagađenje. Značajno sniženje vrednosti osnovnih pokazatelja organskog zagađenja BPK5 (81,84%) i HPK (82,27%) u otpadnoj vodi nakon procesa prečišćavanja potvrđuju efikasnost i opravdanost primenjenog tehnološkog postupka

Experimental and artificial neural network approach for forecasting of traffic air pollution in urban areas: The case of Subotica

In the recent years, artificial neural networks (ANNs) have been used to predict the concentrations of various gaseous pollutants in ambient air, mainly to forecast mean daily particle concentrations. The data on traffic air pollution, irrespective of whether they are obtained by measuring or modelling, represent an important starting point for planning effective measures to improve air quality in urban areas. The aim of this study was to develop a mathematical model for predicting daily concentrations of air pollution caused by the traffic in urban areas. For the model development, experimental data have been collected for 10 months, covering all four seasons. The data about hourly concentration levels of suspended particles with aerodynamic diameter less than 10 μm (PM10) and meteorological data (temperature, air humidity, speed and direction of ind), measured at the measuring station in the town of Subotica from June 2008 to March 2009, served as the basis for developing an ANN-based model for forecasting mean daily concentrations of PM10. The quality of the ANN model was assessed on the basis of the statistical parameters, such as RMSE, MAE, MAPE, and r

Stereospecific ligands and their complexes. Part X: Synthesis, characterization and in vitro antitumoral activity of platinum(IV) complexes with O,O '-dialkyl-(S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoate ligands

Synthesis of four new platinum(IV) complexes 1-4, with bidentate N,N'-ligand precursors O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 were reported. The composition of the novel platinum complexes was determined by elemental analysis and characterizations were performed by infrared, H-1 and C-13 NMR spectroscopy. DFT calculations indicate formation one (R,R) from three possible diastereoisomers (S,S; R,S). Complexes 1-4 displayed potent anticancer activity. IC50 values range from 0.74 to 70 mu M, against tested cell lines, except for CLL cells. The antitumoral activity of 2-4 was found to be considerably stronger to Jurkat and K562. Cell cycle analysis of cell lines showed G1 arrest in the presence of analyzed complexes

In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands

© 2017 Elsevier Inc. Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R2eddl}]PF6 (R2eddl = O,O′-dialkyl-(S,S)-ethylenediamine-N,N′-di-2-(4-methyl)pentanoate, R = n-Pr, n-Bu, n-Pe, i-Bu; 1–4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N′-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24 h, and for the reaction with ascorbic acid in which was reduced immediately. Additionally, 3 interacts with bovine serum albumin (BSA) as proven by UV/Vis spectroscopy. In vitro antitumor activity was determined against human cervix adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human melanoma (Fem-x) cancer cell lines, as well as against non-cancerous human embryonic lung fibroblast cells MRC-5. The highest activity was observed against K562 cells (IC50: 5.04–6.51 μM). Selectivity indices showed that these complexes are less toxic than cisplatin. 3 had a similar viability kinetics on HeLa cells as cisplatin. Drug accumulation studies in HeLa cells showed that the total gold uptake increased much faster than that of cisplatin pointing out that 3 more efficiently enters the cells than cisplatin. Furthermore, morphological and cell cycle analysis reveal that gold(III) complexes induced apoptosis in time- and dose-dependent manner

Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoic acid

Platinum(II) complexes (1-4) with bidentate N,N'-ligands, O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid were synthesized and characterized by IR, (1)H NMR and (13)C NMR spectroscopy and elemental analysis. DFT calculations were performed for the complexes and it was found that only one diastereoisomer could be formed. Cytotoxic activity of complexes 1-4 was determined against chronic lymphocytic leukemia cells (CLL) and compared to the activity of ligand precursors L1 center dot 2HCl-L4 center dot 2HCl and corresponding palladium(II) complexes, [PdCl(2)L] (L = L1-L4). The complexes were found to exhibit significantly higher antitumor activities than cisplatin on CLL cells. Cytotoxic effect of platinum(II) complexes on CLL cells was higher compared to corresponding palladium(II) complexes. In addition the mode of cell death induced by platinum(II) complexes was determined