Three-Tier High-Performance Computing Environment - Baker Hughes

The Baker Hughes high-performance computing environment is deploying a three-tier approach to providing technical computing resources as an alternative to typical high-performance computing. Baker Hughes uses a complete spectrum of computer resources that break from the standards of high-density, dedicated resources. This environment is intended to provide a more flexible and efficient approach that is responsive to business needs. The design has been proven in production systems in the United States and the Russian Federation since the second quarter of 2010 with multiple proprietary and in-house scientific applications. This paper will discuss a computing infrastructure that Baker Hughes has built to better adapt to meet changing requirements in high-performance computing

Socio-gnoseological Issues of Alienation in G. S. Batishchev's Works

In this article, the authors have introduced the gynecological analyses of the category of alienation, the problem of self-knowledge and the ways of its scientific understanding in G.S. Batishchev's works. This time, the authors state that the problem of alienation of personality in modern world is connected with not only just deprivation of attention, but it is also the result of the increased alienation and social problems. The authors have analyzed a number of social relationships, such as social-organic, atomistic, each of which can be further divided into two more classes: utilitarian and pluralistic, polyphonic or harmonic. These classes of relationships are important for understanding of the subject and object, and their interrelations. A particular attention has been paid to social polyphonic ties, which facilitate the advancement of the individual and humanity towards the overcoming of alienation. In addition, the authors have focused their attention on the role of creative activities in the development of social relations. The analyses of relationships described in the works of G.S. Batishchev embark on the way of overcoming of alienation of personality

Социально-политический кризис Сибирского региона в постфевральский период революции 1917 года

The paper considers the problem of the Siberian region general crisis of the 1917 spring. The internal and external contradictions of the transformation process of socio-economic and political relations in Siberia are examined in terms of the post-February all-Russian revolutionary crisis development. The understanding of the socio-political Russian crisis in the spring of 1917, emerging after the February political coup, is essential in studying the revolutionary соnversion process of the early twentieth century Russian society, as this crisis has generally become the turning point in the country's history and objectively led to the October political coup. The Russian revolutionary crisis constituents, its foreign and domestic manifestations require careful investigation in the issue formulation presented in the paper. The development specifics of the revolutionary crisis in the spring of 1917 in the trans-Uralian agricultural colony of the Russian Empire is of scientific interest, as well as the finding of its anti-crisis development scenarios in the paper presented period. The development of the nationwide crisis in Russia in the early twentieth century, due to the complex and contradictory processes of Russian society modernization in completing the industrial civilization and transition to the imperialist development stage, was complicated by the "Siberian historical issues" in the Siberian region. A set of these issues include the incompleteness of the regional peasantry land management, the contradictions between the old peasantry and Stolypin migrants, and also between the peasantry and the privileged regional Cossacks, the agricultural products export problems from Siberia to domestic and foreign markets, or marketing crisis, the contradictions between the regional and metropolis bourgeoisie, or the issue of the Siberians economic inequality, the local industry underdevelopment and the complete dependence of the local population on the factory products supplying from European Russia, or supply crisis, the lack of a country council, or the administrative inequality of Siberia as a colony and metropolis, etc. During the First World War, these problems worsened and led Siberia to a revolutionary situation. Started in Russia in February 1917, the revolution was an attempt to solve the "Siberian historical issues" personally by the regional population, whose social activity ultimately led to an acute socio-political crisis of Siberia, which became a part of the national post-February revolutionary crisis.В статье представлена проблема общего кризиса Сибири весны 1917 года. Исследуются внутренние и внешние противоречия процесса трансформации социально-экономических и политических отношений в контексте постфевральского общероссийского революционного кризиса. Понимание сущности социально-политического кризиса России весны 1917 г., возникшего после Февральского политического переворота, является ключевым в изучении процесса преобразования российского общества начала ХХ в., так как этот кризис во многом стал переломным этапом в истории страны, объективно обусловив Октябрьский политический переворот. В контексте данной постановки представленной в статье проблемы серьезного изучения требуют составные части революционного кризиса России, его внешние и внутренние проявления. Научный интерес представляет специфика развития весной 1917 г. революционного кризиса в Зауральской земледельческой колонии Российской империи, а также поиск вариантов ее антикризисного развития в обозначенный в статье период. Развитие общенационального кризиса России начала ХХ в., обусловленного сложными и противоречивыми процессами модернизации российского общества на путях завершения создания индустриальной цивилизации и перехода в империалистическую стадию развития, в Сибирском регионе отягощалось наличием "сибирских исторических вопросов". Комплекс данных вопросов включал в себя незавершенность землеустройства крестьянства края, противоречия между старожилым крестьянством и столыпинскими переселенцами, а также между крестьянством и привилегированным областным казачеством, проблемы с вывозом из Сибири аграрной продукции на внутренние и внешние рынки, или сбытовой кризис, противоречия между областной буржуазией и буржуазией метрополии, или вопрос экономического неравенства сибиряков, неразвитость местной промышленности и полная зависимость местного населения от поставок фабричной продукции из Европейской России, или снабженческий кризис, отсутствие областного земства, или административное неравенство Сибири как колонии и ее метрополии, и т. д. В годы Первой мировой войны эти проблемы усугубились, что привело Сибирь к состоянию революционной ситуации. Начавшаяся в России в феврале 1917 г. революция стала попыткой разрешить "сибирские исторические вопросы" самим населением края, чья общественная активность, в итоге, привела к острому социально-политическому кризису Сибири, как части общенационального постфевральского революционного кризиса

Innovative activity development at technical university (Russian characteristic aspects, problems and solution)

This study focuses on the identification of actual problems in the development of innovative activity in Russian universities and possible solutions to these problems, taking into consideration the potential of regional innovation systems. The efficiency of the applied approach to the functioning of innovative activity is estimated on the basis of results analysis of research and development (R & D) carried out by the staff of Power engineering Institute of Tomsk Polytechnic University (Russia). The approach to the organization of research and development (R & D) employed in this Institute makes it possible to obtain valuable research findings (articles, patents). However, these findings and data are not in demand and can hardly find their application in the form of innovative production. It is stated that this situation is typical for the University as a whole and is associated with the peculiarities of the functioning of the regional innovation system. It is concluded that it is necessary to search for new approaches in the functioning of innovative activity of university staff and students

Innovative activity development at technical university (Russian characteristic aspects, problems and solution)

This study focuses on the identification of actual problems in the development of innovative activity in Russian universities and possible solutions to these problems, taking into consideration the potential of regional innovation systems. The efficiency of the applied approach to the functioning of innovative activity is estimated on the basis of results analysis of research and development (R & D) carried out by the staff of Power engineering Institute of Tomsk Polytechnic University (Russia). The approach to the organization of research and development (R & D) employed in this Institute makes it possible to obtain valuable research findings (articles, patents). However, these findings and data are not in demand and can hardly find their application in the form of innovative production. It is stated that this situation is typical for the University as a whole and is associated with the peculiarities of the functioning of the regional innovation system. It is concluded that it is necessary to search for new approaches in the functioning of innovative activity of university staff and students

Three-axis MEMS Accelerometer for Structural Inspection

Microelectromechanical system accelerometers are widely used for metrological measurements of acceleration, tilt, vibration, and shock in moving objects. The paper presents the analysis of MEMS accelerometer that can be used for the structural inspection. ANSYS Multiphysics platform is used to simulate the behavior of MEMS accelerometer by employing a finite element model and MATLAB/Simulink tools for modeling nonlinear dynamic systems

Innovation development in Russia: the value aspect

The article examines the problems of the transition of modern Russia towards the formation of an innovative economy, with a special emphasis on the investigation of the key challenges that Russian universities face while training engineers equipped for innovative activities. The paper considers the impact of cultural characteristics of the Russian society on the organization and content of an education process in a technical university, on “producing” engineers capable of developing innovation. In our analysis we use a comparative approach, as well as the outcomes of the etnometric studies based on the method by G. Hofstede. The study presents the comparative analysis of the organization and content of engineering training at two universities representing Russia and the United States. The results of the study show that further productive development of the Russian system of engineering education towards integration with Western systems is possible provided that the value orientation of the Russian state and society is significantly revised

Effect of the anisotropy of monocrystalline silicon mechanical properties on the dynamic characteristics of a micromechanical gyroscope

The aim of the research was to determine the effect of temperature on mechanical properties of a micromechanical gyroscope with the sensing element mounted on a silicon wafer, with the crystallographic orientation of (100) (110) (111). The research is of current relevancy since the metrological characteristics that depend on the eigenfrequencies over the full temperature range are to be controlled. The temperature-modal analysis of the micromechanical gyroscope model was performed with ANSYS program. The temperature dependence for eigenfrequencies was obtained. The dependence of the scale factor on temperature for the most temperature-independent variant of sensor positioning on the wafer was determined. The developed mathematical model was used to find the forms of the output oscillations of the gyroscope

P148 CD68 expression in inflammatory cell infiltration of nonspecific invasive breast cancer

BackgroundTumor-associated macrophages play a main role in tumor progression and dissemination. Taking into account the high heterogeneicity of tumor the different clinical impact of macrophages, infiltrating different sites of tumor, could be expected. The aim was to detect the level of CD68+ cells (macrophages) in the different site of stroma in breast tumor in comparison to clinical course.Materials and methodsOne thirty-six women with nonspecific invasive breast cancer T1-4N0-3M0, who were treated in General Oncology Department of Tomsk Cancer Research Institute (Tomsk, Russia), were included in the present study. Patients did not receive preoperative treatment. The material was fixed in 10–12% neutral formalin. Preparation of the histological material was carried out according to standard procedures. Morphological examination of the surgical specimens was performed by the standard method using a light microscope “Carl Zeiss Axio Lab.A1” (Germany) and slidescanner “MiraxMidiZeiss” (Germany). Metastatic lesion was detected in regional lymph nodes. Immunohistochemical study was performed according to standard procedures. Cytoplasmic expression of these markers was determined in the inflammatory cell infiltrate of different tumor segments: (1) in areas with soft fibrous stroma; (2) in areas with coarse fibrous stroma; (3) in the areas of the so-called “maximum stromal-and-parenchymal relationship” where the individual tumor cells, short strands and groups of tumor cells arranged in soft fibrous stroma; (4) among parenchymal elements; (5) in gaps of ductal tumor structures. Double-stained immunofluorescence was performed according to standard procedures using Leica TCS SP2 laser-scanning spectral confocal microscope (Germany). The following primary antibodies were used: mouse monoclonal anti-human CD68 (BD Biosciences) and rabbit polyclonal anti-stabilin-1 or RS1 (marker of M2 macrophages).ResultsThe highest expression of CD68 in the inflammatory cell infiltrate was detected more frequently in areas with soft fibrous stroma (54%) or the so-called “maximum stromal-and-parenchymal relationship” (79%) in patients with breast cancer. The lowest expression of CD68 was observed in areas with coarse fiber stroma (23%). The CD68-positive cells of the inflammatory infiltrate were located between parenchymal elements of tumor (88%). Inverse correlation (R=−0.67; p=0.02) observed between tumor size and the expression of CD68 in the cells of the inflammatory infiltrate in gaps of tubular tumor structures. The CD68 expression in cells of the inflammatory tumor infiltrate was correlated with the presence of metastatic regional lymph nodes. It was found that in the case of the lymph node metastases the average score of CD68 expression in cells of ductal gaps tumor structures was lower (1.4±0.5) in comparison with the negative lymph nodes case (3.1±1.0; F=10.9; p=0.007). Same time no correlation between the CD68 expression in the inflammatory cell tumor infiltrate and the rate of tumor malignancy was found. Using confocal microscopy domination of CD68+/RS1+ cells were found.ConclusionSo, low CD68 expression level in ductal gaps tumor structures is associated with the presence of metastatic regional lymph nodes

Cancer invasion: patterns and mechanisms

Cancer invasion and the ability of malignant tumor cells for directed migration and metastasis have remained a focus of research for many years. Numerous studies have confirmed the existence of two main patterns of cancer cell invasion: collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. Each pattern of cell migration displays specific morphological features and the biochemical/molecular genetic mechanisms underlying cell migration. Two types of migrating tumor cells, mesenchymal (fibroblast-like) and amoeboid, are observed in each pattern of cancer cell invasion. This review describes the key differences between the variants of cancer cell migration, the role of epithelial-mesenchymal, collective-amoeboid, mesenchymal-amoeboid, and amoeboid- mesenchymal transitions, as well as the significance of different tumor factors and stromal molecules in tumor invasion. The data and facts collected are essential to the understanding of how the patterns of cancer cell invasion are related to cancer progression and therapy efficacy. Convincing evidence is provided that morphological manifestations of the invasion patterns are characterized by a variety of tissue (tumor) structures. The results of our own studies are presented to show the association of breast cancer progression with intratumoral morphological heterogeneity, which most likely reflects the types of cancer cell migration and results from different activities of cell adhesion molecules in tumor cells of distinct morphological structures