Blood groups in alcoholics

Ovo istraživanje, diferencijacija alkoholičara od ostale populacije s obzirom na zastupljenost krvnih grupa, sprovedeno je u dva dijela s vremenskim razmakom od dvije godine. U oba slučaja ispitivane skupine sačinjavali su alkoholičari i nealkoholičari, muškarci, u dobi od 40 do 60 godina, koji su u tekućoj ili prethodnoj godini stupili u invalidsku mirovinu. U prvom dijelu formirane su dvije skupine od po 34 ispitanika, alkoholičari i poredbena skupina, kojima su određivane krvne grupe ABO sustava i Rh krvne grupe. U drugom dijelu obrađene su dvije skupine od po 120 ispitanika, te su im osim spomenutih krvnih grupa određivane i krvne grupe Kell, P, MN, S, C i E. Kriteriji za formiranje skupina alkoholičara u oba slučaja bili su dnevna konzumacija alkohola i alkoholičarski staž. U poredbene skupine uzeti su samo oni koji su pili povremeno manje količine alkohola i nikad se nisu opijali. Obradom dobivenih podataka nisu nađene statistički značajne razlike u distribuciji krvnih grupa u alkoholičara u odnosu na poredbenu skupinu.A study was carried out on two population cohorts during two years to differentiate alcoholics from the rest of population in respect of the incidence of blood groups. The subjects - alcoholics and nonalcoholics, were male workers aged 40-60 years who had retired as disabled during the current or previous year. One cohort consisted of two groups of 34 subjects each, alcoholics and controls, in whom the blood groups of the ABO system and Rh blood groups were determined. The other cohort included two groups of 120 subjects each, who had their ABO, Rh, as well as Kell, P, MN, S, C and E blood groups determined. The criteria for entering the group of alcoholics were based on daily intake of alcohol and duration of alcohol abuse. The control group consisted of the workers who drank occasionally minor amounts of alcoholic beverages. Data processing failed to reveal any statistically significant difference in the distribution of blood groups between alcoholics and control subjects

Krvne grupe u alkoholičara

A study was carried out on two population cohorts during two years to differentiate alcoholics from the rest of population in respect of the incidence of blood groups. The subjects - alcoholics and nonalcoholics, were male workers aged 40-60 years who had retired as disabled during the current or previous year. One cohort consisted of two groups of 34 subjects each, alcoholics and controls, in whom the blood groups of the ABO system and Rh blood groups were determined, The other cohort included two groups of 120 subjects each, who had their ABO, Rh, as well as Kell, P, MN, S, C and E blood groups determined. The criteria for entering the group of alcoholics were based on daily intake of alcohol and duration of alcohol abuse. The control group consisted of the workers who drank occasionally minor amounts of alcoholic beverages. Data processing failed to reveal any statistically significant difference in the distribution of blood groups between alcoholics and control subjects.Ovo istraživanje, diferencijacija alkoholičara od ostale populacije s obzirom na zastupljenost krvnih grupa, sprovedeno je u dva dijela s vremenskim razmakom od dvije godine. U oba slučaja ispitivane skupine sačinjavali su alkoholičari i nealkoholičari, muškarci, u dobi od 40 do 60 godina, koji su u tekućoj ili prethodnoj godini stupili u invalidsku mirovinu. U prvom dijelu formirane su dvije skupine od po 34 ispitanika, alkoholičari i poredbena skupina, kojima su određivane krvne grupe ABO sustava i Rh krvne grupe. U drugom dijelu obrađene su dvije skupine od po 120 ispitanika, te su im osim spomenutih krvnih grupa određivane i krvne grupe Kcell, P, MN, S, C i E. Kriteriji za formiranje skupina alkoholičara u oba slučaja bili su dnevna konzumacija alkohola ,i alkoholičarski staž. U poredbene skupine uzeti su samo oni koji su pili povremeno manje količine alkohola i nikad se nisu opijali. Obradom dobivenih podataka nisu nađene statistički značajne razlike u distribuciji krvnih grupa u alkoholičara u odnosu na poredbenu skupinu

Some Ethiologic Factors of Speech Comprehension Disturbances

Disturbances of speech comprehension were analyzed in a prospective study of 97 children, aged from 23 to 77 months. Pregnancy, birth and early psychomotor development were normal for all the children and no focus of neurological deficit was found. A tonal audiometer did not detect any auditory disturbances, and psychological testing with non-verbal tests showed normal mental functioning for the age. In this group of selected subjects, family and personal case histories were taken. In addition, a detailed neurological physical examination, standard EEG and auditory evoked potentials, and a psychiatric examination were performed during several appointments. The results showed that disturbances in speech comprehension were more frequent in boys, and that in 13.4% of cases it was caused by pervasive developmental disturbances and in 41.24% of cases by external stimulating factors of speech development (pedagogy, social and emotional stimulation and growing up in a multilingual community). The study emphasizes the importance of non-verbal methods for the study of speech and the use of auditory evoked potentials

Importance of Early Drug Treatment in Prognosis of the Landau-Kleffner Syndrome

An expert team conducted a ten-year survey of eight children with Landau-Kleffner syndrome (LKS) identified among children referred to Polyclinic »SUVAG« in Zagreb because of hearing disturbances. Although LKS is a rare disorder it is extremely important to detect it because early diagnosis and prompt medicinal treatment may improve the prognosis, whereas neglect and late diagnosis result in language disability. Standard diagnostic criteria must be established to enable timely treatment

Suplementacija s antioksidansima i serumski lipidi kod bolesnika s Graves-ovom bolesti: Učinak na LDL-kolesterol

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves\u27 disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencing the therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.U ovom istraživanju promatran je učinak suplementacije fiksnom kombinacijom antioksidansa (beta-karoten, selen, vitamin C i E) na koncentracije serumskih lipida, u odnosu na brzinu postizanja eutiroze. Mjerenja su obavljena u bolesnika s novo otkrivenom Graves-ovom bolešću liječenih metimazolom (tiamazolom) prije početka terapije, te nakon 30 i 60 dana. Bolesnici su bili randomizirani u dvije skupine. Test skupinu sačinjavali su bolesnici koji su dodatno uzimali antioksidanse, a kontrolnu skupinu bolesnici koji su uzimali samo metimazol (tiamazol). Koncentracije ukupnog i HDL-kolesterola u serumu rasle su tijekom terapije kod bolesnika iz obje skupine (p < 0,05) no, nisu se međusobno značajno razlikovale 60 dana nakon početka terapije. Kod bolesnika test skupine, koncentracija LDL-kolesterola se značajno povećala (p < 0,005) i bila je značajno različita od one u kontrolnoj skupini (p < 0,005), 60 dana nakon početka liječenja. Rezultati ovog istraživanja ukazuju da suplementacija s ovom kombinacijom antioksidansa nema značajnog utjecaja na promjene koncentracije serumskih lipida kod bolesnika s Graves-ovom bolešću 60 dana nakon početka terapije, s izuzetkom LDL-kolesterola. Zbog značajnog porasta koncentracije LDL-kolesterola kod bolesnika s Graves-ovom bolešću, koji su dodatno uzimali antioksidanse, potrebna su daljnja istraživanja u cilju pojašnjenja opisanih promjena

Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis

Despite the sparseness of the currently available data, there is accumulating evidence of information processing impairment in post-traumatic stress disorder (PTSD). Studies of event-related potentials (ERPs) are the main tool in real time examination of information processing. In this paper, we sought to critically review the ERP evidence of information processing abnormalities in patients with PTSD. We also examined the evidence supporting the existence of a relationship between ERP abnormalities and symptom profiles or severity in PTSD patients. An extensive Medline search was performed. Keywords included PTSD or post-traumatic stress disorder, electrophysiology or EEG, electrophysiology, P50, P100, N100, P2, P200, P3, P300, sensory gating, CNV (contingent negative variation) and MMN (mismatch negativity). We limited the review to ERP adult human studies with control groups which were reported in the English language. After applying our inclusion-exclusion review criteria, 36 studies were included. Subjects exposed to wide ranges of military and civilian traumas were studied in these reports. Presented stimuli were both auditory and visual. The most widely studied components included P300, P50 gating, N100 and P200. Most of the studies reported increased P300 response to trauma-related stimuli in PTSD patients. A smaller group of studies reported dampening of responses or no change in responses to trauma-related and/or unrelated stimuli. P50 studies were strongly suggestive of impaired gating in patients with PTSD. In conclusion, the majority of reports support evidence of information processing abnormalities in patients with PTSD diagnosis. The predominance of evidence suggests presence of mid-latency and late ERP components differences in PTSD patients in comparison to healthy controls. Heterogeneity of assessment methods used contributes to difficulties in reaching firm conclusions regarding the nature of these differences. We suggest that future ERP-PTSD studies utilize standardized assessment scales that provide detailed information regarding the symptom clusters and the degree of symptom severity. This would allow assessment of electrophysiological indices-clinical symptoms relationships. Based on the available data, we suggest that ERP abnormalities in PTSD are possibly affected by the level of illness severity. If supported by future research, ERP studies may be used for both initial assessment and treatment follow-up