Tripodal oxazolidine-N-oxyl diradical complexes of Dy3+ and Eu3+

Two diradical complexes of the formula [LnRad2(CF3SO3)3] c (Ln(III) = Dy, Eu, Rad = 4,4-dimethyl-2,2-bis(pyridin-2-yl)-1,3-oxazolidine-3-oxyl) were obtained in air conditions. These are the first examples of diradical compounds of lanthanides and oxazolidine nitroxide. The complexes were characterized crystallographically and magnetically. Single crystal XRD analysis revealed that their coordination sphere is composed of three monodentate triflates and two tripodal Rad, which coordinate the central atom in a tridentate manner via two N atoms of the pyridine groups and the O atom of a nitroxide group. The LnO5N4 polyhedron represents a spherical capped square antiprism with point symmetry close to C4v. The data of static magnetic measurements are compatible with the presence of two paramagnetic ligands in the coordination sphere of the metal

Effect of organically bound iodine in cattle feed on health indicators

Currently, the problem of iodine deficiency is actual in the world, which may cause a large number of diseases and disorders. The problem of iodine deficiency for humans may be partly solved by enriching agricultural products with iodine, i.e. by providing animals with an increased intake of iodine during their growth. Theoretically, the most effective way to use iodine is the form bound to tyrosine, since diiodotyrosine has been proven to be a thyroxine precursor. Taking it into account, a supplement was developed containing iodine organically bound to tyrosine and histidine. In this work, we studied the effect of this supplement introduced into the diets of cattle on biochemical parameters of animal blood. In the test group, which received the supplement with organically bound iodine, an improvement in nitrogen metabolism was noted compared to the control group. This was most clearly demonstrated by the content of urea, since in the test group, its content decreased by ≈15 percentage points, and by the content of creatinine, since its increase in the test group was more than 20 percentage points. Differences in the parameters of carbohydrate and lipid metabolism between treatments were also noted, as in the blood of animals from the test group, the content of cholesterol, triglycerides, phospholipids, glucose and malondialdehyde was lower than in the control group. In mineral metabolism and morphological parameters, there was no significant difference between treatments. Among the indicators of pigment and hormone metabolism, it is important to note the reduced content of cortisol in the blood of animals from the test group. Its level was lower by ≈17.23 percentage points compared to the control group. A decrease in cortisol levels indicated a lower stress load in the test group. In general, studies have shown that the use of a feed supplement containing organically bound iodine has a positive effect on the metabolism of animals.Currently, the problem of iodine deficiency is actual in the world, which may cause a large number of diseases and disorders. The problem of iodine deficiency for humans may be partly solved by enriching agricultural products with iodine, i.e. by providing animals with an increased intake of iodine during their growth. Theoretically, the most effective way to use iodine is the form bound to tyrosine, since diiodotyrosine has been proven to be a thyroxine precursor. Taking it into account, a supplement was developed containing iodine organically bound to tyrosine and histidine. In this work, we studied the effect of this supplement introduced into the diets of cattle on biochemical parameters of animal blood. In the test group, which received the supplement with organically bound iodine, an improvement in nitrogen metabolism was noted compared to the control group. This was most clearly demonstrated by the content of urea, since in the test group, its content decreased by ≈15 percentage points, and by the content of creatinine, since its increase in the test group was more than 20 percentage points. Differences in the parameters of carbohydrate and lipid metabolism between treatments were also noted, as in the blood of animals from the test group, the content of cholesterol, triglycerides, phospholipids, glucose and malondialdehyde was lower than in the control group. In mineral metabolism and morphological parameters, there was no significant difference between treatments. Among the indicators of pigment and hormone metabolism, it is important to note the reduced content of cortisol in the blood of animals from the test group. Its level was lower by ≈17.23 percentage points compared to the control group. A decrease in cortisol levels indicated a lower stress load in the test group. In general, studies have shown that the use of a feed supplement containing organically bound iodine has a positive effect on the metabolism of animals

Platelet microvesicles and their role in providing hemostatic capacity (literature review)

In recent years the role of microvesicles in endocrine system transmission, in providing cellular connectivity, in transportation of proteins and nucleic acids from one cell to another, in angiogenesis regulation, in inflammatory reactions and in dissemination of tumors is actively studied. This article reviews the mechanisms of microvesicle formation, the structure of microvesicles and their potential value as biomarkers. Among all essential reactions involving microvesicles one thing especially stands out: their direct participation in providing hemostatic reactions for bleeding control in case of a solution of continuity in blood vessels due to different reasons. Platelet microvesicles play an important role in this process, and it has been proved by several experimental and clinical studies. In this review we evaluate prospects for clinical use of one of modern blood components – cryoprecipitate – as the source of platelet microvesicles

A procedure for the change point problem in parametric models based on phi-divergence test-statistics

This paper studies the change point problem for a general parametric, univariate or multivariate family of distributions. An information theoretic procedure is developed which is based on general divergence measures for testing the hypothesis of the existence of a change. For comparing the accuracy of the new test-statistic a simulation study is performed for the special case of a univariate discrete model. Finally, the procedure proposed in this paper is illustrated through a classical change-point example

Чувствительность и специфичность спирометрических показателей при скрининговом исследовании респираторной функции

The data on COPD spread in various regions are extremely inconsistent. One of", the most accessible methods to define the COPD prevalence is screening. Spirometry is a gold standard for COPD detection. The purpose of the present research was to study sensitivity and specificity of spirometry in diagnosing COPD. We examined 3 129 persons aged 17 to 80 yrs. (1 867 males and 1 262 females), pensioners and workers of various enterprises at the Kemerovo city. A great number of persons with reduced respiratory function parameters were found during the screening. After more detailed examination the diagnosis of COPD was verified in 5.4 % of the males and 1.1 % of the females. The disease was detected more often in drivers, railway workers and healthcare workers. According to the screening results the most sensitive diagnostic criterion was FEV1 < 80 % and the most specific parameter was FEV1 / FVC < 70 %. Being highly specific PEF < 80 % had low sensitivity. The increase in PEF higher than 90 °%o enhanced its sensitivity up to 88.6 % and its drop less than 70 % augmented its specificity up to 95.5 %o. The results allow to recommend the PEF < 70 % parameter as a diagnostic criterion of COPD in everyday outpatient work and PEF < 90 % as an indication for more detailed examination.Данные о распространенности хронической обструктивной болезни легких (ХОБЛ) в различных регионах крайне противоречивы. Одним из наиболее доступных методов определения распространенности заболевания является скрининг. Целью исследования является определение чувствительности и специфичности инструментальных методов диагностики ХОБЛ, используемых в процессе скрининга. Обследованы 3 129 мужчин и женщин в возрасте от 17 до 80 лет (1 867 мужчин и 1 262 женщины) — работники различных предприятий и пенсионеры г. Кемерово. На скрининге выявляется высокий процент лиц со сниженными показателями бронхиальной проходимости. Диагноз ХОБЛ верифицирован у 5,4 % мужчин и 1,1 % женщин. Заболевание чаще всего встречается у водителей и работников железнодорожного транспорта. Наиболее чувствительным диагностическим критерием ХОБЛ по результатам скрининга является ОФВ1 <80 %, а наиболее специфичным — ОФВ1 / ФЖЕЛ < 70 %. ПСВ <80 % при высокой специфичности имеет низкую чувствительность. Увеличение критерия до ПСВ <90 % повышает чувствительность теста, а снижение до ПСВ < 70 % увеличивает его специфичность. Это позволяет рекомендовать для повседневной работы амбулаторной службы использование в качестве диагностического критерия ХОБЛ уровень ПСВ < 70 % от должных величин, а уровень ПСВ <90 % как показание для дообследования

[Mn-III(Schiff Base)](3)[Re-IV(CN)(7)], Highly Anisotropic 3D Coordination Framework: Synthesis, Crystal Structure, Magnetic Investigations, and Theoretical Analysis

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