74 research outputs found
Risk factors for hearing loss in children: A systematic literature review and meta-analysis protocol
Background: Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects. Population-based newborn hearing screening programs have been established worldwide to identify children at risk for congenital hearing loss and to follow children at risk for late onset or progressive hearing loss. This article presents the protocol for a systematic review that aims to review the risk factors associated with permanent hearing loss in children, including congenital, early, or late onset. Risk factors associated with progressive hearing loss will be investigated as a secondary aim. Methods: Scientific literature from the following databases will be investigated: MEDLINE, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), Embase, and CINAHL. The primary outcome is a permanent bilateral or unilateral hearing loss with congenital onset or onset during childhood (birth to 18 years). The secondary outcome is progressive hearing loss. Studies must report data on risk factors associated with permanent hearing loss; risk factors may be present at birth or later and result in immediate or delayed hearing loss. Randomized controlled trials, quasi-experimental studies, nonrandomized comparative and non-comparative studies, and case series will be included. The risk of bias will be assessed using the Qualitative Assessment Tool for Quantitative Studies (McMaster University). If aggregation of data is possible for a subsection of studies, we will pool data using meta-analysis techniques. If aggregation of data is not possible, a qualitative synthesis will be presented. We will assess the quality and strength of the overall body of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Discussion: The resulting information will inform the update of a provincial audiological surveillance protocol for the Ontario Infant Hearing Program and will be applicable to early hearing detection and intervention (EHDI) programs worldwide. Systematic review registration: We have registered the protocol in the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018104121
Synthesis, spectroscopy and photophysical properties of ruthenium triazole complexes and their application as dye-molecules in regenerative solar cells
The complexes [Ru(dcb)2(L)] (L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole (2-ppt),
3-(4-phenol)-5-(pyridin-2-yl)-1,2,4-triazole (4-ppt), 3,5-bis(pyrazin-2-yl)-1,2,4-triazole (bpzt),
3-(2-phenol)-5-(pyrazin-2-yl)-1,2,4-triazole (2-ppzt) and dcb = 4,4â-(CO2H)2-2,2â-bipyridine)
have been synthesized, spectroscopically characterized and anchored to nanocrystalline TiO2
electrodes for the conversion of light into electricity in regenerative solar cells. The different
efficiencies observed have been rationalized on the basis of an analytical expression relating
the incident photon-to-current-conversion efficiency (IPCE) to the kinetic parameters of the
relevant electron transfer processes involved in the solar cell
High frequency of central nervous system involvement in transformed Waldenstrom macroglobulinemia
Histologicaltransformation (HT) to diffuse large B-cell lymphoma (DLBCL) is a rare event in Waldenström macroglobulinemia (WM) and is associated with a poor prognosis.1-4 It confers an inferior outcome compared with WM patients without HT.2,3 Most transformed WM patients present with elevated serum lactate dehydrogenase (LDH) levels and extranodal disease.1 Among extranodal sites, the central nervous system (CNS) is one of the most frequently involved sites identified at diagnosis of transformed WM (ranging from 13% to 18%).1,3 However, the prognostic value of CNS involvement is unknown, and the rate of CNS involvement at relapse has not been previously reported in this setting.This work was supported by Cancer Research UK [C355/A26819], FC AECC, and AIRC under the âAccelerator Award Programâ [EDITOR] to M.A. and R.G.-S
Dépistage néonatal de la surdité: Programme de la Fédération Wallonie-Bruxelles
info:eu-repo/semantics/nonPublishe
Lâallaitement maternel aprĂšs la reprise de lâactivitĂ© professionnelle :Ă©tude qualitative sur le vĂ©cu et les pratiques -- SantĂ© publique
info:eu-repo/semantics/nonPublishe
Programme de dépistage néonatal de la surdite en Communauté française de Belgique: évaluation des trois premiÚres années du programme (2007-2009) -- Santé publique
info:eu-repo/semantics/nonPublishe
10 ans de dépistage néonatal de la surdité dans la Fédération Wallonie-Bruxelles
info:eu-repo/semantics/nonPublishe
Le dĂ©pistage nĂ©onatal de la surditĂ© :analyse, Ă©valuation et mise en perspective internationale dâun programme de santĂ©
La prĂ©sente thĂšse sâinscrit dans le cadre de lâĂ©valuation de programmes en santĂ© publique et plus prĂ©cisĂ©ment sur le dĂ©pistage nĂ©onatal de la surditĂ©. Ces programmes sont largement implĂ©mentĂ©s de par le monde et visent Ă diagnostiquer et prendre en charge prĂ©cocement les enfants dĂ©ficients auditifs, afin de leur permettre de se dĂ©velopper de façon optimale, notamment sur le plan du langage ou socio-Ă©motionnel. Ce type de programme de mĂ©decine prĂ©ventive a Ă©tĂ© mis en place par la FĂ©dĂ©ration Wallonie-Bruxelles (FWB), Ă lâĂ©chelle de la communautĂ©, Ă la fin de lâannĂ©e 2006. La thĂšse a pour objectif dâanalyser la mise en place du programme de dĂ©pistage nĂ©onatal de la surditĂ© dans la FWB, dâen Ă©valuer les rĂ©sultats et de le mettre en perspective avec les programmes de dĂ©pistage de la surditĂ© implĂ©mentĂ©s dans les pays de lâUnion EuropĂ©enne. A cette fin, nous avons rĂ©alisĂ© plusieurs Ă©tudes et analyses qui visaient Ă rĂ©pondre Ă cinq objectifs spĂ©cifiques. Le cadre de rĂ©fĂ©rence utilisĂ© pour lâĂ©valuation Ă©tait celui de la recherche Ă©valuative. Tout dâabord, le processus de la mise Ă lâagenda politique du programme dans la FWB et sa mise en place ont Ă©tĂ© analysĂ©s, respectivement sur base du modĂšle de Kindgon et par lâapplication de la matrice SWOT. Ensuite, une analyse des rĂ©sultats chiffrĂ©s gĂ©nĂ©rĂ©s par le programme a Ă©tĂ© rĂ©alisĂ©e, au moyen des indicateurs gĂ©nĂ©ralement utilisĂ©s pour des programmes de dĂ©pistage et les rĂ©sultats pour la FWB ont Ă©tĂ© comparĂ©s Ă ceux dâautres programmes de dĂ©pistage nĂ©onatal de la surditĂ© et aux critĂšres de qualitĂ© du Joint Committee on Infant Hearing, considĂ©rĂ©s comme la rĂ©fĂ©rence pour lâĂ©valuation de ces programmes. Par aprĂšs, les facteurs de risque nĂ©onataux de surditĂ© initialement Ă©laborĂ©s pour le programme de la FWB ont Ă©tĂ© rĂ©visĂ©s, par une approche associant le niveau de preuve (Ă©chelle GRADE) et la recherche dâun consensus auprĂšs dâexperts cliniciens (mĂ©thode Delphi). Ensuite, lâĂąge des enfants lors de leur prise en charge a Ă©tĂ© Ă©tudiĂ© ;pour cela, les donnĂ©es de facturation des actes mĂ©dicaux (donnĂ©es de lâAgence InterMutualiste) ont Ă©tĂ© exploitĂ©es afin dâobjectiver si la prise en charge en Wallonie et Ă Bruxelles Ă©tait plus prĂ©coce depuis la mise en Ćuvre du programme de dĂ©pistage. Enfin, le programme de la FWB a Ă©tĂ© mis en perspective avec ceux implĂ©mentĂ©s dans les pays de lâUnion EuropĂ©enne, sur des questions relatives Ă lâorganisation et au design des programmes ainsi que sur la politique dâidentification des facteurs de risque et la disponibilitĂ© des outcomes dans les programmes. Les rĂ©sultats des analyses et Ă©valuations rĂ©alisĂ©es dans le cadre de cette thĂšse ont mis en Ă©vidence que le programme de la FWB prĂ©sentait des rĂ©sultats favorables, mais nĂ©anmoins amĂ©liorables sur un certain nombre de points, pour lesquels nous avons formulĂ© une sĂ©rie de recommandations. Ces recommandations visent Ă rĂ©orienter le programme de la FWB et incluent notamment le dĂ©veloppement dâun systĂšme dâinformations, la nĂ©cessitĂ© dâune plus grande intĂ©gration du concept dâ« identification et de prise en charge prĂ©coces », la prise en considĂ©ration du raccourcissement du sĂ©jour hospitalier ainsi que la poursuite du monitoring rĂ©gulier et de lâĂ©valuation scientifique du programme. Les recommandations formulĂ©es ont pour finalitĂ© dâaugmenter la qualitĂ© du programme et de favoriser lâidentification et la prise en charge prĂ©coces de lâensemble des nouveau-nĂ©s dĂ©ficients auditifs en FWB.This dissertation takes place in the field of public health program evaluation, and more precisely of newborn hearing screening programs. These programs are largely implemented across the world and aim to early diagnose and enroll hearing-impaired children in intervention programs, in order to improve their language and social-emotional development. A newborn hearing screening program has been implemented in the community (FĂ©dĂ©ration Wallonie-Bruxelles (FWB) at the end of 2006. This dissertation aims to analyze the implementation of the newborn hearing screening program in the FWB, to evaluate its results and to put it in perspective with the programs in the European Union (EU) countries. We performed several studies and analyses to encounter 5 specific goals. First, we analyzed the agenda-setting process in the FWB and the implementation of the program using the Kindgdon model and the SWOT matrix, respectively. Then, we evaluated the outcomes of the program; we compared outcomes from the FWB to those from other programs and to the Joint Committee on Infant Hearing criteria. After, we updated the initial list of neonatal risk factors for hearing loss in the FWB: we rated the level of quality evidence (using GRADE scale) and we obtained a consensus from clinicians about the updated risk factors to implement in the FWB program (Delphi method). Then, we assessed the age of children at audiological intervention: we used the Belgian healthcare billing database to analyze the evolution of the childrenâs age at audiological intervention in Wallonia and Brussels since the implementation of the program. Finally, we put in perspective the program in the FWB with the programs in the EU countries, about organization and design of the programs, risk factors identification and available outcomes in the programs. Results of our analyses and assessments showed positive outcomes for the program in the FWB, even if some parts of the program should be improved. We specifically made recommendations for these points. The recommendations aimed to redirect the newborn hearing screening program in the FWB: we recommend developing a health information system, integrating the âearly hearing detection and intervention programâ concept and the shortening of the birth length in the screening program, and performing regularly monitoring and scientific evaluation of the program. These recommendations aim to improve the quality of the program and to favor early identification and intervention among hearing-impaired children in the FWB.Doctorat en SantĂ© Publiqueinfo:eu-repo/semantics/nonPublishe
Le programme de dĂ©pistage nĂ©onatal de la surditĂ© :10 annĂ©es dâexistence en Belgique francophone
info:eu-repo/semantics/publishe
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