36 Months Survivability And Its Predictors In Patients With Chronic Heart Failure And Decreased Fraction Of Left Ventricular Ejection Depending On Sex

Aim of the work: to compare survivability parameters during 36 months and their predictors among men and women with chronic heart failure and decreased fraction of left ventricular ejection.Materials and methods: the research included 356 patients with CHF (NYHA ІІ –ІV) with decreased LVEF<40 %, 18–75 years old. Using Kaplan-Meier method, there was analyzed the survivability in men and women during 36 months, then there were analyzed independent factors that influenced survivability terms depending on sex using the multiple logistic regression.Results. Our analysis of the survivability of patients with CHF with decreased LVEF demonstrated that the cumulative survival after 3 years of observation was 49 and 51 % for men and women, respectively. The curves of 36 months survivability didn\u27t reliably differ. At the analysis of factors, associated with the bad prognosis, there were observed differences between groups of men and women with CHF. Thus, in men the predictors of 36 month survival were: the thickness of the right ventricle wall, size of the right atrium, end-diastolic volume and end-systolic volume of LV, indices of EDV and ESV of LV, urinary acid level, value of LVEF. In women the predictors of survivability during 3 years were the following parameters: BMI, DM type 2 in an anamnesis, end-diastolic size of LV, end-systolic size of LV, blood glucose level, LVEF.Conclusion. The survivability of men and women with CHF with decreased LVEF during 36 months didn\u27t reliably differ and was 49 and 51 % respectively. But predictors of the lethal outcome in men and women essentially differed during 36 months, and their number is essentially higher in men

Search for ionized jets towards high-mass young stellar objects

We are carrying out multi-frequency radio continuum observations, using the Australia Telescope Compact Array, to systematically search for collimated ionized jets towards high-mass young stellar objects (HMYSOs). Here we report observations at 1.4, 2.4, 4.8 and 8.6 GHz, made with angular resolutions of about 7, 4, 2, and 1 arcsec, respectively, towards six objects of a sample of 33 southern HMYSOs thought to be in very early stages of evolution. The objects in the sample were selected from radio and infrared catalogs by having positive radio spectral indices and being luminous (L_bol > 20,000 L_sun), but underluminous in radio emission compared to that expected from its bolometric luminosity. This criteria makes the radio sources good candidates for being ionized jets. As part of this systematic search, two ionized jets have been discovered: one previously published and the other reported here. The rest of the observed candidates correspond to three hypercompact hii regions and two ultracompact hii regions. The two jets discovered are associated with two of the most luminous (70,000 and 100,000 Lsun) HMYSOs known to harbor this type of objects, showing that the phenomena of collimated ionized winds appears in the formation process of stars at least up to masses of ~ 20 M_sun and provides strong evidence for a disk-mediated accretion scenario for the formation of high-mass stars. From the incidence of jets in our sample, we estimate that the jet phase in high-mass protostars lasts for 40,000 yr.Comment: Accepted for publication in the Astrophysical Journal. (53 pages, 22 Figures) (Color figures were degraded to comply with arXiv requirements

Aspects of actoprotective activity of certain natural compounds with different chemical structure

Objective: the purpose of the present research was the complex assessment of the influence of natural compounds on high-speed characteristics, working capacity, endurance of laboratory mice during physical activities. Materials and methods: actoprotective activity of natural compounds was estimated by the method of shuttle swimming in laboratory mice, anti-hypoxic activity of natural compounds was evaluated on two models: histotoxic and circulatory model. Results: administration of the ATACL compound increased the high-speed and power characteristics and endurance of laboratory animals and also positively affected both histotoxic and circulatory hypoxia. Conclusions: study results showed that compounds under the ATACL code had the most profound actoprotective and anti-hypoxic effects in comparison with other studied compounds. At the same time the pharmacological effect of the use of this compound was comparable to that of the use of reference drugs at all stages of the experiment