Seismic Tremor Reveals Spatial Organization and Temporal Changes of Subglacial Water System

©2019. American Geophysical Union. All Rights Reserved.Subglacial water flow impacts glacier dynamics and shapes the subglacial environment. However, due to the challenges of observing glacier beds, the spatial organization of subglacial water systems and the time scales of conduit evolution and migration are largely unknown. To address these questions, we analyze 1.5‐ to 10‐Hz seismic tremor that we associate with subglacial water flow, that is, glaciohydraulic tremor, at Taku Glacier, Alaska, throughout the 2016 melt season. We use frequency‐dependent polarization analysis to estimate glaciohydraulic tremor propagation direction (related to the subglacial conduit location) and a degree day melt model to monitor variations in melt‐water input. We suggest that conduit formation requires sustained water input and that multiconduit flow paths can be distinguished from single‐conduit flow paths. Theoretical analysis supports our seismic interpretations that subglacial discharge likely flows through a single‐conduit in regions of steep hydraulic potential gradients but may be distributed among multiple conduits in regions with shallower potential gradients. Seismic tremor in regions with multiple conduits evolves through abrupt jumps between stable configurations that last 3–7 days, while tremor produced by single‐conduit flow remains more stationary. We also find that polarized glaciohydraulic tremor wave types are potentially linked to the distance from source to station and that multiple peak frequencies propagate from a similar direction. Tremor appears undetectable at distances beyond 2–6 km from the source. This new understanding of the spatial organization and temporal development of subglacial conduits informs our understanding of dynamism within the subglacial hydrologic system.Raw seismic data described in this paper are available through the Incorporated Research Institutions for Seismology Data Management Center (http://ds.iris.edu/mda/ZQ? timewindow=2015‐2016; Amundson et al., 2015). The raw weather data used in this paper can be found through the Arctic Data Center (https://doi.org/ 10.18739/A2H98ZC7V; Bartholomaus & Walter, 2018). Python code developed to carry out the analyses presented here is available at https://github.com/ voremargot/Seismic‐Tremor‐Reveals‐ Spatial‐Organization‐and‐Temporal‐ Changes‐of Subglacial‐Water‐System and https://github.com/ tbartholomaus/med_spec. This study was made possible with support from the University of Texas Institute for Geophysics and the University of Idaho. We thank Ginny Catania for the loan of weather stations. J. P. W.'s and J. M. A.'s contributions to this work were supported by the U.S. National Science Foundation (OPP‐1337548 and OPP‐ 1303895). T. C. B. thanks Dylan Mikesell for an early conversation, which inspired the analysis presented here.Ye

Seismic Tremor Reveals Spatial Organization and Temporal Changes of Subglacial Water System

©2019. American Geophysical Union. All Rights Reserved.Subglacial water flow impacts glacier dynamics and shapes the subglacial environment. However, due to the challenges of observing glacier beds, the spatial organization of subglacial water systems and the time scales of conduit evolution and migration are largely unknown. To address these questions, we analyze 1.5‐ to 10‐Hz seismic tremor that we associate with subglacial water flow, that is, glaciohydraulic tremor, at Taku Glacier, Alaska, throughout the 2016 melt season. We use frequency‐dependent polarization analysis to estimate glaciohydraulic tremor propagation direction (related to the subglacial conduit location) and a degree day melt model to monitor variations in melt‐water input. We suggest that conduit formation requires sustained water input and that multiconduit flow paths can be distinguished from single‐conduit flow paths. Theoretical analysis supports our seismic interpretations that subglacial discharge likely flows through a single‐conduit in regions of steep hydraulic potential gradients but may be distributed among multiple conduits in regions with shallower potential gradients. Seismic tremor in regions with multiple conduits evolves through abrupt jumps between stable configurations that last 3–7 days, while tremor produced by single‐conduit flow remains more stationary. We also find that polarized glaciohydraulic tremor wave types are potentially linked to the distance from source to station and that multiple peak frequencies propagate from a similar direction. Tremor appears undetectable at distances beyond 2–6 km from the source. This new understanding of the spatial organization and temporal development of subglacial conduits informs our understanding of dynamism within the subglacial hydrologic system.Raw seismic data described in this paper are available through the Incorporated Research Institutions for Seismology Data Management Center (http://ds.iris.edu/mda/ZQ? timewindow=2015‐2016; Amundson et al., 2015). The raw weather data used in this paper can be found through the Arctic Data Center (https://doi.org/ 10.18739/A2H98ZC7V; Bartholomaus & Walter, 2018). Python code developed to carry out the analyses presented here is available at https://github.com/ voremargot/Seismic‐Tremor‐Reveals‐ Spatial‐Organization‐and‐Temporal‐ Changes‐of Subglacial‐Water‐System and https://github.com/ tbartholomaus/med_spec. This study was made possible with support from the University of Texas Institute for Geophysics and the University of Idaho. We thank Ginny Catania for the loan of weather stations. J. P. W.'s and J. M. A.'s contributions to this work were supported by the U.S. National Science Foundation (OPP‐1337548 and OPP‐ 1303895). T. C. B. thanks Dylan Mikesell for an early conversation, which inspired the analysis presented here.Ye

Chronic Cavitary Pulmonary Aspergillosis: An Unusual Cause of Chronic Cough, Pleuritic Chest Pain, and Hemoptysis in a 24-Year-Old Coal Mine Worker

Pulmonary Aspergillus infections are caused by the ubiquitous fungus mold when spores found in compost, dust, and plant material are inhaled. Manifestation of the disease is represented by a delicate balance between host and pathogen interactions, making Aspergillus infection more commonly observed in immunocompromised individuals. Chronic cavitary pulmonary aspergillosis (CCPA) is a subtype of pulmonary Aspergillosis associated with history of chronic or prior lung disease. Here we present the case of a non-immunocompromised 24-year-old male with a history of intermittent asthma with chronic pulmonary symptoms and finding of a lung mass on imaging. We describe the diagnostic challenge and surgical treatment of CCPA in medically refractory disease

Seismic Tremor Reveals Spatial Organization and Temporal Changes of Subglacial Water System

Subglacial water flow impacts glacier dynamics and shapes the subglacial environment. However, due to the challenges of observing glacier beds, the spatial organization of subglacial water systems and the time scales of conduit evolution and migration are largely unknown. To address these questions, we analyze 1.5‐ to 10‐Hz seismic tremor that we associate with subglacial water flow, hat is, glaciohydraulic tremor, at Taku Glacier, Alaska, throughout the 2016 melt season. We use frequency‐dependent polarization analysis to estimate glaciohydraulic tremor propagation direction (related to the subglacial conduit location) and a degree day melt model to monitor variations in melt‐water input. We suggest that conduit formation requires sustained water input and that multiconduit flow paths can be distinguished from single‐conduit flow paths. Theoretical analysis supports our seismic interpretations that subglacial discharge likely flows through a single‐conduit in regions of steep hydraulic potential gradients but may be distributed among multiple conduits in regions with shallower potential gradients. Seismic tremor in regions with multiple conduits evolves through abrupt jumps between stable configurations that last 3–7 days, while tremor produced by single‐conduit flow remains more stationary. We also find that polarized glaciohydraulic tremor wave types are potentially linked to the distance from source to station and that multiple peak frequencies propagate from a similar direction. Tremor appears undetectable at distances beyond 2–6 km from the source. This new understanding of the spatial organization and temporal development of subglacial conduits informs our understanding of dynamism within the subglacial hydrologic system

Redox Proteomic Identification of HNE-Bound Mitochondrial Proteins in Cardiac Tissues Reveals a Systemic Effect on Energy Metabolism After Doxorubicin Treatment

Doxorubicin (DOX), one of the most effective anticancer drugs, is known to generate progressive cardiac damage, which is due, in part, to DOX-induced reactive oxygen species (ROS). The elevated ROS often induce oxidative protein modifications that result in alteration of protein functions. This study demonstrates that the level of proteins adducted by 4-hydroxy-2-nonenal (HNE), a lipid peroxidation product, is significantly increased in mouse heart mitochondria after DOX treatment. A redox proteomics method involving two-dimensional electrophoresis followed by mass spectrometry and investigation of protein databases identified several HNE-modified mitochondrial proteins, which were verified by HNE-specific immunoprecipitation in cardiac mitochondria from the DOX-treated mice. The majority of the identified proteins are related to mitochondrial energy metabolism. These include proteins in the citric acid cycle and electron transport chain. The enzymatic activities of the HNE-adducted proteins were significantly reduced in DOX-treated mice. Consistent with the decline in the function of the HNE-adducted proteins, the respiratory function of cardiac mitochondria as determined by oxygen consumption rate was also significantly reduced after DOX treatment. Treatment with Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, an SOD mimic, averted the doxorubicin-induced mitochondrial dysfunctions as well as the HNE–protein adductions. Together, the results demonstrate that free radical-mediated alteration of energy metabolism is an important mechanism mediating DOX-induced cardiac injury, suggesting that metabolic intervention may represent a novel approach to preventing cardiac injury after chemotherapy

The effectiveness of peer health coaching in improving glycemic control among low-income patients with diabetes: protocol for a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Although self-management support improves diabetes outcomes, it is not consistently provided in health care settings strained for time and resources. One proposed solution to personnel and funding shortages is to utilize peer coaches, patients trained to provide diabetes education and support to other patients. Coaches share similar experiences about living with diabetes and are able to reach patients within and beyond the health care setting. Given the limited body of evidence that demonstrates peer coaching significantly improves chronic disease care, this present study examines the impact of peer coaching delivered in a primary care setting on diabetes outcomes.</p> <p>Methods/Design</p> <p>The aim of this multicenter, randomized control trial is to evaluate the effectiveness of utilizing peer coaches to improve clinical outcomes and self-management skills in low-income patients with poorly controlled diabetes. A total of 400 patients from six primary health centers based in San Francisco that serve primarily low-income populations will be randomized to receive peer coaching (n = 200) or usual care (n = 200) over 6 months. Patients in the peer coach group receive coaching from patients with diabetes who are trained and mentored as peer coaches. The primary outcome is change in HbA1c. Secondary outcomes include change in: systolic blood pressure, body mass index (BMI), LDL cholesterol, diabetes self-care activities, medication adherence, diabetes-related quality of life, diabetes self-efficacy, and depression. Clinical values (HbA1c, LDL cholesterol and blood pressure) and self-reported diabetes self-efficacy and self-care activities are measured at baseline and after 6 months for patients and coaches. Peer coaches are also assessed at 12 months.</p> <p>Discussion</p> <p>Patients with diabetes, who are trained as peer health coaches, are uniquely poised to provide diabetes self management support and education to patients. This study is designed to investigate the impact of peer health coaching in patients with poorly controlled diabetes. Additionally, we will assess disease outcomes in patients with well controlled diabetes who are trained and work as peer health coaches.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01040806">NCT01040806</a></p

Adolescent intermittent ethanol (AIE) produces lasting, sex-specific changes in rat body fat independent of changes in white blood cell composition

Early initiation of alcohol use during adolescence, and adolescent binge drinking are risk factors for the development of alcohol use disorder later in life. Adolescence is a time of rapid sex-dependent neural, physiological, and behavioral changes as well as a period of heightened vulnerability to many effects of alcohol. The goal of the present studies was to determine age-related changes in blood (leukocyte populations) and body composition across adolescence and early adulthood, and to investigate whether adolescent intermittent ethanol (AIE) exposure would alter the trajectory of adolescent development on these broad physiological parameters. We observed significant ontogenetic changes in leukocyte populations that were mirrored by an age-related increase in cytokine expression among mixed populations of circulating leukocytes. Despite these developmental changes, AIE did not significantly alter overall leukocyte numbers or cytokine gene expression. However, AIE led to sex-specific changes in body fat mass and fat percentage, with AIE-exposed male rats showing significantly decreased fat levels and female rats showing significantly increased fat levels relative to controls. These changes suggest that while AIE may not alter overall leukocyte levels, more complex phenotypic changes in leukocyte populations could underlie previously reported differences in cytokine expression. Coupled with long-term shifts in adipocyte levels, this could have long-lasting effects on innate immunity and the capacity of individuals to respond to later immunological and physiological threats

Ultrafast structure and dynamics in ionic liquids: 2D-IR spectroscopy probes the molecular origin of viscosity

The viscosity of imidazolium ionic liquids increases dramatically when the strongest hydrogen bonding location is methylated. In this work, ultrafast two-dimensional vibrational spectroscopy of dilute thiocyanate ion ([SCN] -) in 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C4C1im][NTf2]) and 1-butyl-2,3- dimethylimidazolium bis(trifluoromethylsulfonyl)imide ([C4C 1C12im][NTf2]) shows that the structural reorganization occurs on a 26 ± 3 ps time scale and on a 47 ± 15 ps time scale, respectively. The results suggest that the breakup of local ion-cages is the fundamental event that activates molecular diffusion and determines the viscosity of the fluids. © 2014 American Chemical Society