Regulation Of Epidermal Proliferation And Differentiation In Psoriasis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111132/1/jde01861.pd

Consensus conference on cyclosporin A microemulsion for psoriasis, June 1996

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75561/1/j.1365-2133.1996.d01-1061.x.pd

Molecular mechanisms of retinoid actions in skin

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154473/1/fsb2010009001.pd

Enabling the Intellectually Disabled Mind through Architecture

According to the World Health Organization, roughly 10% of the world population live with mental disability or impairment (Fujira, 2005). For the intellectually disabled, finding a purpose and independence as one transitions into yound adulthood can prove troublesome given their unique shortcomings. In 2015, it was estimated 80,000 intellectually disabled adults were held on waiting lists for residential placement in government-funded programs that could take up to 10 years to complete. Autism Speaks approximates that this number will increase by half a million in that same time span (Lutz, 2015). A greater initiative must take place to assist these individuals in finding as sense of stability in an increasingly dynamic global setting. Some built initiatives have come to exist specifically for those with Autism, such as the Autism Treatment Center of San Antonio. However, these interventions often neglect a large subdivision of the mentally-disabled population known as Down Syndrome. This genetic condition occurs in nearly one in 1000 live births, making it one of the most common birth defects (Rodrigues, 2019). The scope of projects with the intellectually-disabled in mind should be expanded to meet their particular needs so that they may reside alongside their autistic counterparts. With this diversification, the lack of independence in the mentally-disabled community of adults can be tackled more efficiently through the lens of the built environment. Through manipulation of the built world an Integrated Community can be established to enable these individuals to live their lives within the context of the working world. The resulting project will exhibit this objective by creating a space where individuals with special needs can become become a part of a subcommunity that is assimilated independently into the general public, rather than seperated. Although, creating such a space for the intellectually impaired presents unique challenges in its own right. Mental disabilities create internal obstacles for each individual that can prevent them from functioning properly in a given setting. The design solution to be presented will allow them to not only address, but overcome, these obstacles. This solution will serve to remediate sensory overload and similar symptoms, while also allowing for incremental exposure to them so that they can better handle their presence in everyday life. This creates a functional paradox requiring careful compositional considerations in order to create a controlled, but flexible, environmental setting. The aforementioned paradox in turn is the driving force behind the resulting architectural work. This controlled environment will be attained through the implementation of architectural tools and techniques, such as light manipulation, acoustic control, materiality, spatial sequencing, and overall understanding of form and space

A Study of Snippet Length and Informativeness: Behaviour, Performance and User Experience

The design and presentation of a Search Engine Results Page (SERP) has been subject to much research. With many contemporary aspects of the SERP now under scrutiny, work still remains in investigating more traditional SERP components, such as the result summary. Prior studies have examined a variety of different aspects of result summaries, but in this paper we investigate the influence of result summary length on search behaviour, performance and user experience. To this end, we designed and conducted a within-subjects experiment using the TREC AQUAINT news collection with 53 participants. Using Kullback-Leibler distance as a measure of information gain, we examined result summaries of different lengths and selected four conditions where the change in information gain was the greatest: (i) title only; (ii) title plus one snippet; (iii) title plus two snippets; and (iv) title plus four snippets. Findings show that participants broadly preferred longer result summaries, as they were perceived to be more informative. However, their performance in terms of correctly identifying relevant documents was similar across all four conditions. Furthermore, while the participants felt that longer summaries were more informative, empirical observations suggest otherwise; while participants were more likely to click on relevant items given longer summaries, they also were more likely to click on non-relevant items. This shows that longer is not necessarily better, though participants perceived that to be the case - and second, they reveal a positive relationship between the length and informativeness of summaries and their attractiveness (i.e. clickthrough rates). These findings show that there are tensions between perception and performance when designing result summaries that need to be taken into account

THE EPIDERMIS AND CYCLIC AMP

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73687/1/j.1365-2133.1974.tb06390.x.pd

CUTANEOUS ANGIITIS (VASCULITIS)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66185/1/j.1365-4362.1978.tb06119.x.pd

Viscoelasticity and metastability limit in supercooled liquids

A supercooled liquid is said to have a kinetic spinodal if a temperature Tsp exists below which the liquid relaxation time exceeds the crystal nucleation time. We revisit classical nucleation theory taking into account the viscoelastic response of the liquid to the formation of crystal nuclei and find that the kinetic spinodal is strongly influenced by elastic effects. We introduce a dimensionless parameter \lambda, which is essentially the ratio between the infinite frequency shear modulus and the enthalpy of fusion of the crystal. In systems where \lambda is larger than a critical value \lambda_c the metastability limit is totally suppressed, independently of the surface tension. On the other hand, if \lambda < \lambda_c a kinetic spinodal is present and the time needed to experimentally observe it scales as exp[\omega/(\lambda_c-\lambda)^2], where \omega is roughly the ratio between surface tension and enthalpy of fusion