Volcano plots constructed from iTRAQ quantification data.

<p>The volcano plots show how much and how significantly proteins identified in the exploratory phase of the study using representative pooled samples were altered due to the presence of both MIAC and HCA. The top five proteins with the most profound change are highlighted by their abbreviated names (H4 - histone H4; H32 - histone H3.2; H2B1L - histone H2B type 1-L; CAMP – cathelicidine; PERM – myeloperoxidase). Proteins that were found significantly changed (<i>p</i><0.01) in both replicates are coded in red.</p

Demographic and clinical characteristics of women and newborns involved in the exploratory cohort.

<p>Demographic and clinical characteristics of women and newborns involved in the exploratory cohort.</p

Prediction potential of amniotic fluid cathelicidin cut-off level >4.0 ng/ml for the presence of both MIAC and HCA in PPROM pregnancies.

<p>Prediction potential of amniotic fluid cathelicidin cut-off level >4.0 ng/ml for the presence of both MIAC and HCA in PPROM pregnancies.</p

Demographic and clinical characteristics of the women and newborns involved in the replication cohort.

<p>Demographic and clinical characteristics of the women and newborns involved in the replication cohort.</p

Graphic presentation of the methodology of sample processing and LC-MS/MS analysis of pooled case and control samples.

<p>Graphic presentation of the methodology of sample processing and LC-MS/MS analysis of pooled case and control samples.</p

Maternal and neonatal characteristics in the group of women with spontaneous preterm delivery and the group of women with term delivery.

<p>Maternal and neonatal characteristics in the group of women with spontaneous preterm delivery and the group of women with term delivery.</p

A two-column scatter graph of median (IQR: 25^th; 75^th percentiles) amniotic fluid CRP levels in the groups.

<p>A two-column scatter graph of median (IQR: 25^th; 75^th percentiles) amniotic fluid CRP levels in the groups.</p

Flow chart showing selection of study participants.

<p>Flow chart showing selection of study participants.</p

The ten most dysregulated proteins in both duplicates (115/114 and 117/116) from the exploratory proteomics analysis, where 115 and 117 represent the channels for the cases and 114 and 116 represent the channels for the controls.

<p>The ten most dysregulated proteins in both duplicates (115/114 and 117/116) from the exploratory proteomics analysis, where 115 and 117 represent the channels for the cases and 114 and 116 represent the channels for the controls.</p