17 research outputs found
Association of thyroid function with arterial pressure in normotensive and hypertensive euthyroid individuals: A cross-sectional study
<p>Abstract</p> <p>Background</p> <p>Overt hypothyroidism has been associated with arterial hypertension and increased arterial stiffness. Results in euthyroid individuals have been conflicting. We investigated associations of thyroid function with systolic (SAP) and diastolic (DAP) arterial pressure in euthyroid subjects.</p> <p>Methods</p> <p>311 euthyroid individuals (185 women, mean age 43.9 ± 9) without a history of diabetes attending a preventive medicine program were examined. Subjects receiving thyroxine (10.6%) were excluded; 19.3% had hypertension, 43% had a family history for hypertension. TSH, fT4, thyroid autoantibodies, insulin, glucose were measured. The "fT4.TSH product", which has been suggested as a T4 resistance-index, was calculated.</p> <p>Results</p> <p>TSH range was 0.1–8, median 1.4 mU/L, fT4 range was 11.5–25.2 pmol/L, median 17.4. TSH and the "fT4.TSH product" were positively associated with DAP (p < 0.03, for both associations). In the subgroup of individuals with TSH levels 0.36–2.5 mU/L, both TSH and the "fT4.TSH product" were positively correlated with SAP (r = +0.133 p = 0.044, r = +0.152 p = 0.026) and DAP (r = +0.243 p < 0.001, r = +0.252 p < 0.001 respectively); in multivariate analysis the "fT4.TSH product" was a significant predictor of DAP independently of HOMA-IR and BMI (p < 0.001). Similar associations were found when only the non-hypertensive subjects were analysed (p = 0.004). Hypertensive patients had higher TSH levels (p = 0.02) and belonged more frequently to the subgroup with TSH > 2 mU/L (35.3% vs 21.3%, p = 0.045).</p> <p>Conclusion</p> <p>In euthyroid individuals the association of thyroid function with diastolic arterial pressure remains significant even when a stricter "normal range" for TSH levels is considered. The "freeT4.TSH" product appears to be an even stronger predictor of DAP, independently of HOMA insulin resistance index and obesity.</p
Free thyroxine is an independent predictor of subcutaneous fat in euthyroid individuals
Objective: Thyroid function parameters have been associated with
obesity, but associations with the type of adiposity have not been
examined. We used ultrasound (US) to assess regional adiposity and
investigated associations of thyroid function with parameters of central
obesity.
Design: Cross-sectional study.
Methods: A total of 303 apparently healthy individuals (age 42.9+/-8.8,
body mass index (BMI) 19.0-43.3, median 26.2 kg/m(2), 181 women) were
examined for indices of the metabolic syndrome. BMI, waist and hip
circumference, abdominal subcutaneous fat (SF), and preperitoneal fat
(PF) layer was estimated. TSH, free thyroxine (fT(4)), triiodothyronine
(T-3), thyroid autoantibodies, insulin, glucose, and lipid levels were
measured. Subjects receiving T-4 (9.2%) were excluded.
Results: SF and SF/PF ratio were inversely correlated with fT(4) levels
(r=-0.169. P=0.023, r=-0.193, P=0.009 respectively). In multivariate
analysis, fT(4) was a predictor of SF and SF/PF, independently of age,
sex, and smoking. SF correlated with TSH levels (r=0.149, P=0.037). PF
and SF were positively associated with T-3 levels (r=0.245, P=0.004 and
r=0.189, P=0.019 respectively). T-3 levels were positively associated
with BMI (r=0.257, P=0.0004). waist perimeter (r=0.324, P<0.0001), and
waist-to-hip ratio (WHR; r=0.363, P<0.0001). The T-3/fT(4) ratio was
positively correlated with SF (r=0.182, P=0.028), WHR (r=0.267,
P=0.0003), and BMI (r=0.146, P=0.043).
Conclusions: Increasing SI, accumulation as assessed by US is associated
with lower fT(4) and higher TSH levels among euthyroid slightly
overweight individuals. These associations indicate that subtle
variation in thyroid function may participate in regional adiposity
Stauffer's syndrome as a prominent manifestation of renal cancer: a case report
Background: Renal cell carcinoma is associated with a wide spectrum of para-neoplastic syndromes, which may be precursors of primary or recurrent disease. Non-metastatic hepatic dysfunction in patients suffering from renal cell carcinoma is known as Stauffer's syndrome. It is associated with the production of cytokines by the tumour, and several biochemical abnormalities, including elevated serum alkaline phosphatase. Case presentation: We describe a 36-year-old woman presenting with various non-specific, systemic disease manifestations, and elevated liver enzymes due to cholestasis as the main laboratory abnormality. Imaging studies showed a solid mass in the left kidney, which, after surgical excision, was identified as renal cell carcinoma. No metastasis was found. Conclusion: Stauffer syndrome may precede other manifestations of renal cell carcinoma. In case of unexplained abnormal liver function, particularly in presence of systemic symptoms, underlying renal cell carcinoma should be excluded by focused investigations. © 2009 Kranidiotis et al; licensee BioMed Central Ltd