560 research outputs found
Risky music listening, permanent tinnitus and depression, anxiety, thoughts about suicide and adverse general health
Objective: To estimate the extent to which exposure to music through earphones or headphones with MP3 players or at discotheques and pop/rock concerts exceeded current occupational safety standards for noise exposure, to examine the extent to which temporary and permanent hearing-related symptoms were reported, and to examine whether the experience of permanent symptoms was associated with adverse perceived general and mental health, symptoms of depression, and thoughts about suicide. Methods: A total of 943 students in Dutch inner-city senior-secondary vocational schools completed questionnaires about their sociodemographics, music listening behaviors and health. Multiple logistic regression analyses were used to examine associations. Results: About 60% exceeded safety standards for occupational noise exposure; about one third as a result of listening to MP3 players. About 10% of the participants experienced permanent hearing-related symptoms. Temporary hearing symptoms that occurred after using an MP3 player or going to a discotheque or pop/rock concert were associated with exposure to high-volume music. However, compared to participants not experiencing permanent hearing-related symptoms, those experiencing permanent symptoms were less often exposed to high volume music. Furthermore, they reported at least two times more often symptoms of depression, thoughts about suicide and adverse self-assessed general and mental health. Conclusions: Risky music-listening behaviors continue up to at least the age of 25 years. Permanent hearing-related symptoms are associated with people's health and wellbeing. Participants experiencing such symptoms appeared to have changed their behavior to be less risky. In order to induce behavior change before permanent and irreversible hearingrelated symptoms occur, preventive measurements concerning hearing health are needed
Detection of Supernova Neutrinos by Neutrino-Proton Elastic Scattering
We propose that neutrino-proton elastic scattering, ,
can be used for the detection of supernova neutrinos in scintillator detectors.
Though the proton recoil kinetic energy spectrum is soft, with , and the scintillation light output from slow, heavily ionizing
protons is quenched, the yield above a realistic threshold is nearly as large
as that from . In addition, the measured proton
spectrum is related to the incident neutrino spectrum, which solves a
long-standing problem of how to separately measure the total energy and
temperature of , , , and .
The ability to detect this signal would give detectors like KamLAND and
Borexino a crucial and unique role in the quest to detect supernova neutrinos.Comment: 10 pages, 9 figures, revtex
Realization of quantum process tomography in NMR
Quantum process tomography is a procedure by which the unknown dynamical
evolution of an open quantum system can be fully experimentally characterized.
We demonstrate explicitly how this procedure can be implemented with a nuclear
magnetic resonance quantum computer. This allows us to measure the fidelity of
a controlled-not logic gate and to experimentally investigate the error model
for our computer. Based on the latter analysis, we test an important assumption
underlying nearly all models of quantum error correction, the independence of
errors on different qubits.Comment: 8 pages, 7 EPS figures, REVTe
Potential for Supernova Neutrino Detection in MiniBooNE
The MiniBooNE detector at Fermilab is designed to search for oscillation appearance at and to make a
decisive test of the LSND signal. The main detector (inside a veto shield) is a
spherical volume containing 0.680 ktons of mineral oil. This inner volume,
viewed by 1280 phototubes, is primarily a \v{C}erenkov medium, as the
scintillation yield is low. The entire detector is under a 3 m earth
overburden. Though the detector is not optimized for low-energy (tens of MeV)
events, and the cosmic-ray muon rate is high (10 kHz), we show that MiniBooNE
can function as a useful supernova neutrino detector. Simple trigger-level cuts
can greatly reduce the backgrounds due to cosmic-ray muons. For a canonical
Galactic supernova at 10 kpc, about 190 supernova
events would be detected. By adding MiniBooNE to the international network of
supernova detectors, the possibility of a supernova being missed would be
reduced. Additionally, the paths of the supernova neutrinos through Earth will
be different for MiniBooNE and other detectors, thus allowing tests of
matter-affected mixing effects on the neutrino signal.Comment: Added references, version to appear in PR
Generation of two-mode nonclassical states and a quantum phase gate operation in trapped ion cavity QED
We propose a scheme to generate nonclassical states of a quantum system,
which is composed of the one-dimensional trapped ion motion and a single cavity
field mode. We show that two-mode SU(2) Schr\"odinger-cat states, entangled
coherent states, two-mode squeezed vacuum states and their superposition can be
generated. If the vibration mode and the cavity mode are used to represent
separately a qubit, a quantum phase gate can be implemented.Comment: to appear in PR
Neutrino mass from cosmology: Impact of high-accuracy measurement of the Hubble constant
Non-zero neutrino mass would affect the evolution of the Universe in
observable ways, and a strong constraint on the mass can be achieved using
combinations of cosmological data sets. We focus on the power spectrum of
cosmic microwave background (CMB) anisotropies, the Hubble constant H_0, and
the length scale for baryon acoustic oscillations (BAO) to investigate the
constraint on the neutrino mass, m_nu. We analyze data from multiple existing
CMB studies (WMAP5, ACBAR, CBI, BOOMERANG, and QUAD), recent measurement of H_0
(SHOES), with about two times lower uncertainty (5%) than previous estimates,
and recent treatments of BAO from the Sloan Digital Sky Survey (SDSS). We
obtained an upper limit of m_nu < 0.2eV (95% C.L.), for a flat LambdaCDM model.
This is a 40% reduction in the limit derived from previous H_0 estimates and
one-third lower than can be achieved with extant CMB and BAO data. We also
analyze the impact of smaller uncertainty on measurements of H_0 as may be
anticipated in the near term, in combination with CMB data from the Planck
mission, and BAO data from the SDSS/BOSS program. We demonstrate the
possibility of a 5 sigma detection for a fiducial neutrino mass of 0.1eV or a
95% upper limit of 0.04eV for a fiducial of m_nu = 0eV. These constraints are
about 50% better than those achieved without external constraint. We further
investigate the impact on modeling where the dark-energy equation of state is
constant but not necessarily -1, or where a non-flat universe is allowed. In
these cases, the next-generation accuracies of Planck, BOSS, and 1% measurement
of H_0 would all be required to obtain the limit m_nu < 0.05 - 0.06eV (95%
C.L.) for the fiducial of m_nu = 0eV. The independence of systematics argues
for pursuit of both BAO and H_0 measurements.Comment: 22 pages, 6 figures, 12 table
Generation of arbitrary two dimensional motional state of a trapped ion
We present a scheme to generate an arbitrary two-dimensional quantum state of
motion of a trapped ion. This proposal is based on a sequence of laser pulses,
which are tuned appropriately to control transitions on the sidebands of two
modes of vibration. Not more than laser pulses are needed to
generate a pure state with upper phonon number and in the and
direction respectively.Comment: to appear in PR
[F-18]FDG-PET accurately identifies pathological response early upon neoadjuvant immune checkpoint blockade in head and neck squamous cell carcinoma
Purpose To investigate the utility of [F-18]FDG-PET as an imaging biomarker for pathological response early upon neoadjuvant immune checkpoint blockade (ICB) in patients with head and neck squamous cell carcinoma (HNSCC) before surgery.Methods In the IMCISION trial (NCT03003637), 32 patients with stage II-IVb HNSCC were treated with neoadjuvant nivolumab with (n = 26) or without (n = 6) ipilimumab (weeks 1 and 3) before surgery (week 5). [F-18]FDG-PET/CT scans were acquired at baseline and shortly before surgery in 21 patients. Images were analysed for SUVmax, SUVmean, metabolic tumour volume (MTV), and total lesion glycolysis (TLG). Major and partial pathological responses (MPR and PPR, respectively) to immunotherapy were identified based on the residual viable tumour in the resected primary tumour specimen (<= 10% and 11-50%, respectively). Pathological response in lymph node metastases was assessed separately. Response for the 2 [F-18]FDG-PET-analysable patients who did not undergo surgery was determined clinically and per MR-RECIST v.1.1. A patient with a primary tumour MPR, PPR, or primary tumour MR-RECIST-based response upon immunotherapy was called a responder.Results Median Delta SUVmax, Delta SUVmean, Delta MTV, and Delta TLG decreased in the 8 responders and were significantly lower compared to the 13 non-responders (P = 0.05, P = 0.002, P < 0.001, and P < 0.001). A Delta MTV or Delta TLG of at least - 12.5% detected a primary tumour response with 95% accuracy, compared to 86% for the EORTC criteria. None of the patients with a Delta TLG of - 12.5% or more at the primary tumour site developed a relapse (median FU 23.0 months since surgery). Lymph node metastases with a PPR or MPR (5 metastases in 3 patients) showed a significant decrease in SUVmax (median - 3.1, P = 0.04). However, a SUVmax increase (median + 2.1) was observed in 27 lymph nodes (in 11 patients), while only 13 lymph nodes (48%) contained metastases in the corresponding neck dissection specimen.Conclusions Primary tumour response assessment using [F-18]FDG-PET-based Delta MTV and Delta TLG accurately identifies pathological responses early upon neoadjuvant ICB in HNSCC, outperforming the EORTC criteria, although pseudoprogression is seen in neck lymph nodes. [F-18]FDG-PET could, upon validation, select HNSCC patients for response-driven treatment adaptation in future trials.Otorhinolaryngolog
Simulation and validation studies of a large drift tube Muon Tracker
Cosmic ray muons are massive, charged particles created from high energy cosmic rays colliding with atomic nuclei in Earth’s atmosphere. Because of their high momenta and weak interaction, these muons can penetrate through large thicknesses of dense material before being absorbed, making them ideal for nondestructive imaging of objects composed of high-Z elements. A Giant Muon Tracker with two horizontal 8 × 6 in.2 and two vertical 6 × 6 in.2 modules of drift tubes was used to measure muon tracks passing through samples placed inside the detector volume. The experimental results were used to validate a Monte Carlo simulation of the Giant Muon Tracker. The imaging results of simulated samples were reconstructed and compared with those from the experiment, which showed excellent agreement
The Majorana neutrino masses, neutrinoless double beta decay and nuclear matrix elements
The effective Majorana neutrino mass is evaluated by using the latest results
of neutrino oscillation experiments. The problems of the neutrino mass
spectrum,absolute mass scale of neutrinos and the effect of CP phases are
addressed. A connection to the next generation of the neutrinoless double beta
decay (0nbb-decay) experiments is discussed. The calculations are performed for
76Ge, 100Mo, 136Xe and 130Te by using the advantage of recently evaluated
nuclear matrix elements with significantly reduced theoretical uncertainty. An
importance of observation of the 0nbb-decay of several nuclei is stressed.Comment: 29 pages, 5 figures, EXO (10 t) experiment considere
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