Effect of Temperature and Age of Concrete on Strength – Porosity Relation

The compressive strengths of unsealed samples of concrete at the age of 180 days and have been measured at temperatures 20 °C, 300 °C, 600 °C and 900 °C. All of tests were performed for cold material. We compared our results with those obtained in [10] for the same type of concrete (age 28, resp. 90 days and measured at temperature ranging from 20 °C to 280 °C). Dependencies of compressive strength and porosity were correlated together and compared for the samples of age 28, 90 and 180 days. Behaviour of concrete of the age 90, resp. 180 days confirms generally accepted hypothesis that with increasing porosity strength of the concrete decreases. It has to be stressed out, howerer, that concrete samples of the age 28 days exhibit totally opposite dependency.

Influence of ? Irradiation on Concrete Strength

Aging of concrete due to gamma irradiation. Strength of concrete are in a good correspondency with already known results.

Effect of Thermal Cycling on the Strength and Texture of Concrete for Nuclear Safety Structures

The effect of thermal cycling (freezing and thawing) on the texture and strength of two types of concrete is studied: 1. Concrete used for a containment structure at NPP Temelín (Czech Republic) - so-called TEMELÍN concrete.2. Highly resistant PENLY concrete, which was used as a standard because of its high quality, proved by the research carried out in a European Commission project. The results for the two samples of concrete are compared

Influence of ? Irradiation on Concrete Strength

Aging of concrete due to gamma irradiation. Strength of concrete are in a good correspondency with already known results.

Effect of Thermal Cycling on the Strength and Texture of Concrete for Nuclear Safety Structures

The effect of thermal cycling (freezing and thawing) on the texture and strength of two types of concrete is studied: 1. Concrete used for a containment structure at NPP Temelín (Czech Republic) - so-called TEMELÍN concrete.2. Highly resistant PENLY concrete, which was used as a standard because of its high quality, proved by the research carried out in a European Commission project. The results for the two samples of concrete are compared

Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer.

Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been shown to associate with these TFs and contribute to aggressive cancers including prostate cancer (PC). Here, we show that chromatin accessibility defines castration-resistant prostate cancer (CRPC). We show that the deregulation of androgen receptor (AR) expression is a driver of chromatin relaxation and that AR/androgen-regulated bromodomain-containing proteins (BRDs) mediate this effect. We also report that BRDs are overexpressed in CRPCs and that ATAD2 and BRD2 have prognostic value. Finally, we developed gene stratification signature (BROMO-10) for bromodomain response and PC prognostication, to inform current and future trials with drugs targeting these processes. Our findings provide a compelling rational for combination therapy targeting bromodomains in selected patients in which BRD-mediated TF binding is enhanced or modified as cancer progresses