Additional file 1: of Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review

Supplementary material. Table S1. Comparison of guidelines and recommendations definitions of exacerbations of COPD. Table S2. Comparison of guidelines and recommendations assessment of exacerbation risk. (DOCX 30 kb

Effect of number of COPD patients seen in a month on a discrepancy between subjectively classified patients into GOLD 2011 groups and classification achieved by objective assessment using software.

<p>Effect of number of COPD patients seen in a month on a discrepancy between subjectively classified patients into GOLD 2011 groups and classification achieved by objective assessment using software.</p

Use of ICS in monotherapy or combination therapy.

<p>Use of ICS in monotherapy or combination therapy.</p

Contribution to the misclassification of an individual clinical component interpreted within the GOLD 2011 classification matrix.

<p>The percentage indicates relative frequency of misclassified cases attributable to a given clinical component. A sole effect is responsible for misclassified cases due to an obvious error in interpretation of one specific primary clinical parameter. The combined effect is responsible for misclassified cases due to an obvious error in interpreting both clinical criteria on the same axis (mMRC dyspnea scale and CAT respective bronchial obstruction and number of COPD exacerbations/year). <i>Statistical probabilities were calculated of pair-wise contrasts as follows; mMRC dyspnea scale vs. CAT (p>0.05), mMRC dyspnea scale vs. bronchial obstruction based on post bronchodilator FEV1 (p<0.0001), mMRC dyspnea scale vs. number of exacerbations/year (p<0.0001), CAT vs. bronchial obstruction (p<0.0001), CAT vs. number of exacerbations/year (p<0.0001), bronchial obstruction vs. number of exacerbations/year (p<0.0001).</i></p

Original version of the Czech Republic map in SVG format.

<p>Original version of the Czech Republic map in SVG format.</p

Numbers of COPD specialists involved in the research by country regions of the Czech Republic.

<p>Numbers of COPD specialists involved in the research by country regions of the Czech Republic.</p