Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).

<p>AshTest had significant higher AUROCs than AST/ALT for all scores and lesions. NonBinROC is the Obuchowski measure, the non-binary estimate of ordinal test performance. AshTest had significant Obuchowski measures than AST/ALT for ASH scores and for PMN and Mallory.</p><p>Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).</p

Flow chart of inclusion.

<p>Flow chart of inclusion.</p

Concordance between ASH grades presumed by AshTest and by biopsy.

<p>The histological score is the sum of the 3 elementary lesion grades: Ballooning, PMN and Mallory bodies.</p><p>Concordance between ASH grades presumed by AshTest and by biopsy.</p

Comparison between included and non-included patients.

<p>¹One FibroTest was not reliable, and all AshTest were reliable</p><p>Comparison between included and non-included patients.</p

Area under the ROC curves (AUROC) of AshTest versus AST/ALT, Maddrey, and MELD scores.

<p>0.815 (0.639–0.910), 0.565 (0.348–0.725), 0.571 (0.448–0.730) and 0.537 (0.327–0.751) respectively, for the diagnosis of at least one histological features of alcoholic hepatitis. All comparisons were significant (P<0.01) between AshTest and AST/ALT, Maddrey and MELD scores.</p

Box Plots of Biomarkers according to liver injury.

<p>FibroTest according to fibrosis stage (Panel A), SteatoTest according to steatosis grade (Panel B), ActiTest according to NAS score (Panel C) to ballooning (Panel D) and inflammation (Panel E) in 494 patients. Notched box plots showing the relationship between tests and the stage/grade of liver injury. The horizontal line inside each box represents the median, and the width of each box the median±1.57 interquartile range/√n (to assess the 95% level of significance between group medians). Failure of the shaded boxes to overlap signifies statistical significance (P<0.05). The horizontal lines above and below each box encompass the interquartile range (from the 25th to 75th percentile), and the vertical lines from the ends of the box encompass the adjacent values (upper: 75th percentile plus 1.5 times interquartile range; lower: 25th percentile minus 1.5 times interquartile range).</p

Quantitative concordance between elasticity values and severity of fibrosis, adjusted by inflammation, and steatosis.

<p>The strength of concordance was assessed by the Lin concordance correlation coefficient. Fibrosis, Steatosis and Inflammation were assessed by FibroTest, ActiTest and SteatoTest respectively.</p

Applicability of fibrosis tests in investigated patients.

<p>Applicability of fibrosis tests in investigated patients.</p

Characteristics of 494 obese patients included in each population.

1<p>When data are missing the number of patients with data not missing is given.</p

Included patients with morbid obesity.

<p>*In the Lille cohort a total of 296 patients have been excluded, 94 because histological staging was missing, 19 were duplicate, 229 for biomarkers non assessed (including 39 with more than one cause of exclusion) and 3 patients with not interpretable FT/ST (extreme value of triglycerides/glucose/ApoA1 detected by security algorithms). In the Paris cohort 6 patients have excluded, 2 with BMI lower than 35, 3 because histological staging was missing, and one for biomarkers not assessed. In the Bethune cohort 8 patients have excluded, 3 with BMI lower than 35, and 5 because histological staging was missing.</p