Dynamic contrast enhancement of the LV myocardium apical (orange) and inferolateral (blue) in Patient 2 with a HR varying from 60–110 bpm and several extrasytoles during CT perfusion examination.

<p>Perfusion analysis of original images shows irregular zigzag pattern of the resulting curves (a). A continuous run of the time density curves is illustrated after motion correction and spatio-temporal filtering (b). Both curves (orange and blue) illustrate normal contrast enhancement of the LV myocardium with no evidence of perfusion deficit. Figs. c-f: Shown are the axial images (and the ROIs) at two different instances in time – the original uncorrected (c, d) and after motion correction plus spatio-temporal smoothing (e, f). Images c and e are from cardiac cycle 3; d and f are from cardiac cycle 8. In the original images (c & d), the two ROIs do not cover the same area of the myocardium at both time points, but instead cover adjacent tissue and the contrast-filled lumen of the LV, resulting in several spikes in (a). In contrast, consistent measurements of the same part of the myocardium after motion correction (e & f) leading to coherent time-density curves (b) for both ROIs. All CT images are presented using the same window level and window width.</p

Coloured perfusion maps for original data (a), motion corrected data (b) and combined motion-corrected and spatio-temporal filtered data (c) of Patient 1 in axial orientation.

<p>As a reference, short axis view late enhancement MR images are shown (d) presenting partly transmural infarction of the inferolateral wall. LV endocardium and epicardium are outlined in red. The perfusion defect of the inferior and lateral LV wall is visible in all CT perfusion images, with improved delineation of the hypoperfused and remote myocardium using motion correction (b) and best image quality using combined reconstruction algorithm with motion correction and spatio-temporal filtering (c). Thus the transmural extent of the infarction as diagnosed in MRI (d) can be distinguished only in combined motion-corrected and spatio-temporal filtered images (c).</p