6,309 research outputs found

    Performance of the Lester battery charger in electric vehicles

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    Tests are performed on an improved battery charger. The primary purpose of the testing is to develop test methodologies for battery charger evaluation. Tests are developed to characterize the charger in terms of its charge algorithm and to assess the effects of battery initial state of charge and temperature on charger and battery efficiency. Tests show this charger to be a considerable improvement in the state of the art for electric vehicle chargers

    Antenna pointing compensation based on precision optical measurement techniques

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    The pointing control loops of the Deep Space Network 70 meter antennas extend only to the Intermediate Reference Structure (IRS). Thus, distortion of the structure forward of the IRS due to unpredictable environmental loads can result in uncompensated boresight shifts which degrade blind pointing accuracy. A system is described which can provide real time bias commands to the pointing control system to compensate for environmental effects on blind pointing performance. The bias commands are computed in real time based on optical ranging measurements of the structure from the IRS to a number of selected points on the primary and secondary reflectors

    Historical Perspectives on Violence Against Women

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    Three great bodies of thought have influenced western society’s views and treatment of women: Judeo-Christian religious ideas, Greek philosophy and the Common Law legal code. All three traditions have, by and large, assumed patriarchy as natural – that is male domination stemming from the view of male superiority. As part of the culture perpetuated by these ideologies, violence towards women was seen as a natural expression of male dominance. This paper contains three main themes. The first establishes patriarchy as an early pattern of military societies and the subsequent emergence of the Judeo-Christian, Greek and legal cultural paradigm as ideological justification. The second provides evidence as to how the above attitudes were interwoven in European and American values. The third theme analyzes the new 18th century cultural paradigm of liberalism which rejected male dominance, lessened the manifestation of patriarchy, without removing its cultural memory, thereby, allowing violence towards women to remain

    Edmonds v. Compagnie Generale Transatlantique, 443 U.S. 256 (1979)

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    Cell-Type Specific Extracellular Matrix Signaling in the Opioid-Addicted Synapse

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    To date, heroin abuse is a leading cause of drug overdose-related deaths in the United States, highlighting a need for further research elucidating effects of maladaptive neuroadaptations following prolonged heroin use. Activation of the tetrapartite synapse in nucleus accumbens core (NAcore), which comprises of pre- and post-synapse, astrocytic processes, and surrounding extracellular matrix (ECM), has been linked to increased relapse vulnerability. Specifically, degradation of ECM by activated matrix metalloproteinases (MMPs) is involved in extracellular synaptic remodeling both constitutively and transiently in extinguished and drug seeking conditions, respectively. Although increases in MMP-2,9 fluorescence can be localized to soma and dendritic processes of medium spiny neurons (MSNs) in NAcore, it is unknown which specific cell types of the tetrapartite synapse harbor changes in MMP activity under extinguished and cued reinstatement conditions (15min). I used a viral transfection strategy to label NAcore D1 and D2 MSNs and astrocytes in heroin self-administering rats, and measured localization of activated MMP-2,9 gelatinolytic puncta after FITC-gelatin microinjection under extinguished and reinstated conditions. Astrocytes exhibited reduced synaptic MMP activity co-localized with peripheral processes after extinction, but gelatinolytic activity was restored to control levels during cued heroin seeking. For D1 MSNs, I observed transient increases in MMP-9 activity localized around dendritic segments in reinstated animals compared to both saline controls and heroin-extinguished animals. D2 MSNs showed increased MMP-2 activity only in heroin-extinguished animals, but MMP-2,9 activity after 15 min reinstatement was transiently reduced to saline levels. In both cases, increased MMP activity was enhanced around dendritic spines compared to dendrite shaft. The observed changes in MMP activity around D1 and D2 MSNs during heroin seeking are transient and reversible as gelatinolytic puncta around both cell types returned to extinguished levels after 120min of heroin seeking. I also examined effects of home-cage abstinence and heroin refraining on MMP activity selectively around D1 and D2 MSNs. Finally, I studied involvement of tissue inhibitors of metalloproteinases (TIMPs) in NAcore during reinstatement to determine if local MMP inhibition around specific cell-types is necessary for cued heroin seeking. These findings reveal how NAcore ECM signaling underlying constitutive and transient synaptic plasticity relies in part on specific cell-types
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