Indagini preliminari sull’espressione immunoistochimica della proteina p53 nel seminoma del cane

SUMMARY - Tlie p53 protein is a transcription factor inducing celi cycle arresi and apoptosis against a DNA damage. p53 mutations might lead to lose its inibitoring growth functions and contribute to not controlied cellular proliferation. Mutations and/or overexpression of p53 are thè most comnion genetic alterations found in human cancer. The role of thè p53 protein in cancerogenesis m domestic animals is stili largely unknown. This prelimmary study investigates thè expression of p?3 in 16 semmomas of thè dog using a standard streptavidinbiotin peroxidase method after microwave antigen retrieval. In 9 diffuse seminomas tlie mtensity of p53 expression is of low degree (^), in 5 diffuse seminomas is of middle degree (++) and m 2 intratubular seminomas is of higt degree (+++). The results suggest tlie p53 expression m seminoma of thè dog decreases with advancing stage of neoplastic process

Origin of Enzootic Intranasal Tumor in the Goat (Capra hircus): A Glycohistochemical Approach

Enzootic intranasal tumor (EIT) appears glandular in type and has recently been classified as an adenocarcinoma of low malignancy. The aim of this study was to characterize the secretion of surface glycoconjugates (GCs) in EIT and in normal respiratory and olfactory mucosae of the goat by means of conventional and lectin histochemistry, in order to shed light on the histogenesis of EIT. Morphologic and ultrastructural investigations showed two growth types of EIT: i.e., tubular and papillary patterns. Conventional histochemistry revealed the presence of neutral and carboxylated GCs in the olfactory glands and in the tubular part of EIT, as well neutral and sulphated GCs in the respiratory glands and in the papillary part of EIT, suggesting that the papillary pattern tumor arises from the respiratory glands, whereas the tubular portion of EIT arises from the olfactory glands. Lectin histochemistry gave further information on the expressed GCs

Peritonite cronica incapsulante in due cani

SUMMARY - A conditìon resembUng humaii sclerosing encapsulating peritonifis was identified in 2 dogs. Both dogs had similar clinical signs: chronìc weight loss, vomiting, ascites. The addominal fluid was red-tinged. Laparotomy revealed chronic peritoniris. Necropsy revealed , in case 1, a sac-like formation occupying thè peritoneal cavity and massive adhesions araong thè addominal viscere; in case 2, thè multiple surfaces covered with granulatici! tissue or fibrous tissue or botli wcre me typical appearence. The predominant histological abnormality was marked peritoneal and serosal fibrosis. Causes of chronic encapsulating peritonitis were unknown

Mesotelioma pericardio in un cane

SUMMARY - This report describes thè anatomohistopatological, ultrastructural and immunohistochemical findings in a 7-year-old mongrel bitch affected with pericardial mesothelioma. The bitch during 8 month had clinical signs suggesting pericardial effusion. Histological examination of thè biopsy specimen revealed nests of suspected mesothelial neoplastic cells. Given its unfavourable prognosisi thè dog was euthanatìzed. At necropsy, thè parietal and visceral surface of thè pericardium were covered with irregular brown-yellow,velvety nodules and plaques, Neoplastic nodules and plaques were also present in thè pleura. Histologically, diffuse cuboidal epithelioid cells cove-l ring papìllary projections on a spindle celi fibrovascular core were found. The ultrastructural and immunohistochemical findings were characteristic of mesothelial cells

Su un caso di carcinoma a cellule squamose dello stomaco nel cavallo

SUMMARY - The Authors describe thè clinical, pathological and histotogical features of a case of squamous celi carcinoma (SCC) in a borse. A 13 year old, male, castrated, Irish horse, was kepi under observation after being sick for 9 months with thè following symptoms: dysoressia, chronic weight loss, sensory depression, pallor of thè apparent mucosae and, in thè last 30 days, diarrhoea, raeìena and diffuse oedemas. Physical and endoscopie examination and laboratory test» suggested a cachectic syndrome secondary to a neoplastic disease involving thè alimentary traci. Due to thè unfavourable prognosis, thè horse was euthanised according to thè owner's will, Anatomo-histopathological examination showed thè presence of stomach SCC. In this note thè Authors emphasize thè difficuity in diagnosing such neoplastic disease intra vitam

Indagini istologiche, immunocitochimiche ed ultrastrutturali su quattro casi di tumore a cellule della granulosa-teca della cavalla

SUMMARY - The histological, immunocytochemical and ultrastructural characteristics of Leydig-like cells were investigated in four equine gjanulosa-theca cells tumore (GTCT). Proliferation of thè granulosa-theca cells in a follicular pattern was thè prominent microscopie finding in each tumor. Neoplastic cells were also arranged in cords, trabecular pattems or in solid insular masses. The amount of stremai or thecal reactions varied both in thè different cases and within thè same tumor. Leydig-like cells were present arnong theca cells in 3 cases. Immunocytochemical staining for testosterone was strongly positive in these cells. Ultrastructurally they were similar to thè interstitial cells of thè testìs. The rcsults of thè present study show that thè number of Leydig-like cells is related to plasma testosterone concentration and that they appear to be a source of thè testosterone production

Lesioni similangiomatose in un cane

non present

La Ciatostomiasi larvale nel cavallo – Aspetti anatomoistipatologici

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