Cervical sympathetic nerve activity (left) and integrated electrical activity of cervical sympathetic nerve (right).

<p>A: Normotensive Wistar rats (n = 6). B: Wistar rats with two-kidney one-clip renovascular hypertension (n = 6). C: Wistar-Kyoto rats (n = 6). D: Spontaneously hypertensive rats (n = 7).</p

Systolic blood pressure and cardiac beat-to-beat interval over 8 weeks after left renal artery clipping in Wistar rats.

*<p><i>p</i><0.05 versus controls.</p

The relationship between baroreflex (BR) sensitivity and systolic blood pressure (SBP) in the pooled samples of Wistar rats with stable hypertension (n = 10) and without hypertension (n = 10) 8 weeks after induction of two-kidney one-clip renovascular hypertension.

<p>The inverse correlation between BR sensitivity and SBP is observed (r = 0.69, <i>p</i><0.01).</p

Hemodynamic parameters in the animals with sinoaortic denervation.

<p>A: Systolic blood pressure (SBP) and B: Cardiac beat-to-beat (RR) interval before and after renal artery clipping in the rats with sinoaortic denervation. BV, baseline value; BP, blood pressure. *<i>p</i><0.05 versus baseline.</p

The relative contribution of low-, mid-, and high-amplitude integrated activity in the cervical sympathetic nerve (in percentage to total electrical activity) in the experimental groups.

<p>2K1C – Wistar rats with 2-kidney 1-clip renovascular hypertension; WKY – Wistar-Kyoto rats; SHR – spontaneously hypertensive rats.</p

Experimental design.

<p>A: Series 1, evaluation of baroreflex function and time course of blood pressure changes after induction of two-kidney one-clip renovascular hypertension, as well as at investigation of the relationship between initial baroreflex sensitivity and severity of renovascular hypertension. B: Series 2, effect of sinoaortic denervation on the incidence and time to onset of two-kidney one-clip hypertension. C: Series 3, assessment of cervical sympathetic nerve activity in normo- and hypertensive animals. BP, blood pressure; BR, arterial baroreflex; cSNA, cervical sympathetic nerve activity; HTN, hypertension; 2K1C, two-kidney one-clip; MBP, mean blood pressure; RR, cardiac beat-to-beat interval; SAD, sinoaortic denervation; SBP, systolic blood pressure; SHR, spontaneously hypertensive rats; WKY, Wistar-Kyoto rats.</p