1 research outputs found
1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for Peptide Surrogates
An approach to the synthesis of 1-alkyl-5-((di)alkylamino)tetrazoles
by nucleophilic substitution in 1-alkyl-5-sulfonyltetrazoles with
anions generated from the primary or secondary amines was developed.
Tolerance of the method to the presence of some functional groups
(i.e., protected amine) in both components of the reaction was demonstrated.
Obtained tetrazoles are promising building blocks for the design of
peptide surrogates, in particular, for replacement approaches of alkyl
urea derivatives