The linkage between psoriasis and non-alcoholic fatty liver disease: a literature review

Psoriasis is a chronic systemic inflammatory disease mainly affecting the skin. Population-based surveys have shown a higher prevalence of non-alcoholic fat liver disease (NAFLD) in patients with psoriasis compared with the general population, especially in those with a greater psoriasis area and severity index (PASI). It is speculated that similar pathogenic bases may play a role in this association, highlighting insulin resistance and the release of inflammatory cytokines as the most likely causes. In the present work, we review basic aspects of the relationship between psoriasis and NAFLD.</p

Inherited epidermolysis bullosa: clinical and therapeutic aspects Epidermólise bolhosa hereditária: aspectos clínicos e terapêuticos

Inherited epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders that present with skin and, in some cases, mucosal fragility, predisposing patients to the development of blisters and/or erosions after minimal trauma or friction. Children with a recurrent history of these kinds of lesions or neonates that present them in the absence of another reasonable explanation should be investigated. Diagnosis must be based on clinical and histopathological findings. To date, management of inherited EB basically consists in avoiding traumas that trigger lesions, as well as preventing infection and facilitating healing of the wounds with the systematic use of bandages.<br>A epiderm&#243;lise bolhosa heredit&#225;ria (EBH) compreende um grupo heterog&#234;neo de desordens gen&#233;ticas que t&#234;m em comum a fragilidade cut&#226;nea e, em alguns casos mucosa, predispondo ao desenvolvimento de bolhas e/ou eros&#245;es ap&#243;s fric&#231;&#227;o ou trauma m&#237;nimo. Crian&#231;as com hist&#243;ria recorrente deste tipo de les&#227;o ou neonatos que as apresentem na aus&#234;ncia de outra explica&#231;&#227;o plaus&#237;vel devem ser investigados. O diagn&#243;stico deve se basear em achados cl&#237;nicos e histopatol&#243;gicos. At&#233; o presente momento, o manejo da EBH consiste basicamente em evitar os traumas desencadeadores das les&#245;es, bem como evitar a infec&#231;&#227;o e facilitar a cicatriza&#231;&#227;o das feridas com o uso sistem&#225;tico de curativos

Brazilian Consensus on Photoprotection

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of nonmelanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection