Synthesis, crystal structure, spectroscopic and superoxide dismutase activity of copper(II) and nickel(II) complex of N '-[phenyl(pyridin-2-yl)methylidene]benzohydrazone

1695-1700Two binary copper(II) and nickel(II) complexes viz., [Cu(L)(HL)]NO3.H2O (1)<b style="mso-bidi-font-weight: normal"> and [Ni(L)(HL)]NO3.H2O (<b style="mso-bidi-font-weight: normal">2) of hydrazone Schiff base ligand (where L/HL = N'-[phenyl(pyridin-2-yl)methylidene]benzohydrazone) have been synthesized and characterized. Both the complexes (1) and (<b style="mso-bidi-font-weight: normal">2) and ligand (HL) are structurally characterized using single crystal X-ray diffraction technique. They crystallize in monoclinic crystal system in the space group P21/n. The observed trends in spin-Hamiltonian parameters <i style="mso-bidi-font-style: normal">g║>g┴>2.03 indicates a dx2-y2 ground state in complex (<b style="mso-bidi-font-weight: normal">1). In the absorption spectra in 100% DMSO, complex (2) exhibits a <i style="mso-bidi-font-style: normal">d-d transition at ~900 nm, which is assigned to ν1 band (3<i style="mso-bidi-font-style: normal">A2g→3T2g in octahedral parentage). Superoxide dismutase activities of both complexes reveal the dismutation of superoxide (O2-)

Copper(II) promoted hydrolysis of 2,4,6-tris(2-pyridyl)-1,3,5-triazine: Synthesis, characterization and biological activities of the hydrolytic products

717-723The hydrolysis of 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz) yield the compounds bis(2-pyridylcarbonyl)amide and 2-picolinamide. From these hydrolytic products, two copper(II) complexes viz,. [Cu(IDA)(2-pa)].2H2O (1) and [Cu(bpca)(H2O)2]NO3.2H2O (2) [where IDA = iminodiacetic acid, 2-pa = 2-picolinamide and bpca = bis(2-pyridyl-carbonyl)amido] have been isolated and structurally characterized by single crystal X-ray diffraction studies. Both complexes belong to the triclinic crystal system having space group P-1. Complex (<b style="mso-bidi-font-weight: normal">2) shows significant hydrogen bonding and non-covalent π…π stacking interactions. In complex (2), Bifurcated (three centered) hydrogen bonds have been detected. The electron paramagnetic mononuclear copper(II) complexes display X-band epr spectra in 100% DMSO at 77 K giving g > g   > 2.0023, indicating <i style="mso-bidi-font-style: normal">dx2-y2 ground state in a square pyramidal geometry. In-vitro antibacterial study has been assayed against some selected microorganisms using agar disc diffusion method. The DNA cleavage activities of both complexes are also investigated by gel electrophoresis using pBR 322 DNA