Tourist business in turbulence

The article deals with the factors of turbulence which engulfed the tourism industry with a «whirling flood». The main causes of the impact on the tourist market are: devaluation of the rouble, the bankruptcy of the largest tour operators and Transaero Airlines, the sanctions of the West, the introduction of fingerprinting for Russian tourists, as well as the causes of non-economic nature. In the "new reality" there is an objective need to develop some new management strategies that take into account the likelihood of unexpected fluctuation

Role of Post-Neoadjuvant therapy with trastuzumab emtansine in HER2-positive breast cancer

The widespread introduction of anti-HER2 agents has changed the natural course of Her2-positive breast cancer. The use of trastuzumab, and later dual anti-HER2 blockade with pertuzumab, in neoadjuvant regimens significantly increased the chances of complete cure. However, among patients with early and locally advanced forms of Her2-positive cancer, there is a cohort with an extremely unfavorable prognosis – tumors that have not achieved complete pathomorphological regression after neoadjuvant chemotherapy.The presence of a residual tumor in Her2-positive breast cancer has long been only a prognostically unfavorable factor without the potential to influence disease outcome. The results of the international phase III study KATHERINE, which demonstrated the high efficacy of post-adjuvant therapy with trastuzumab emtansine (T-DM1) in this patient cohort, have established a new standard of care. Due to T-DM1 adjuvant therapy, the possibility to significantly improve long-term results determined the predictive characteristics of the morphological response to the choice of treatment tactics, which became an important argument in favor of neoadjuvant therapy in patients with not only locally advanced but also primarily resectable Her2-positive breast cancer, followed by personalization of therapy.This article presents our own experience with post-neoadjuvant therapy with trastuzumab emtansine in a young patient with a residual tumor. The data of the main studies in early Her2-positive breast cancer are summarized

Characteristics of hotel premises in Belgorod city

Hotel industry is regarded as one of the factors in the development of tourism and the initial basis for planning the production of the tourist product. It determines the specificity of the development of tourism, being the basis for the production of the tourism product in planning the priorities of the investment policy. The article presents the results of the authors’s research, as well as materials open print and electronic resources. The authors analyzed the state of hotel real estate market of Belgorod, the structure of the number of rooms, hotel occupancy assessed by type of rooms, highlighted promising areas of the hotel business. It should be noted, that the development of domestic tourism, the growth of business and cultural activity in the region will contribute to the further development of tourism infrastructure and, in particular, the hotel industryyesБелгородский государственный университе

Analyzing the independent tourism development in Belgorod on the basis of queries

The analysis of the demand for tourist attractions in Belgorod is based on user requests in Yandex. The demand for tourist attractions in Belgorod is stabl

Transformation of museum product

Today, each museum needs to develop an active strategy of market development, which is preceded by a comprehensive analysis of potential consumers of the museum product, on the basis of which the directions of development will be proposed. The conducted research allowed us to reveal a number of problems which are connected with necessity of transformation of the museum product providing satisfaction of visitor’s requirements and, at the same time, increase in the income of the museu

The infrastructure of public catering in the context of tourist city space development

To assess the impact of environmental factors on the activities of catering enterprises of the Belgorod region and the quality of customer service, the authors proposed a method using STEP-analysis and SWOT-analysis. The analysis of environmental factors was carried out on the basis of the expert evaluation results conducted in two stage

Spectrum of conditionally pathogenic microflora isolated from the prostate secret in chronic bacterial prostatitis patients

The article represents a description for microbiocenosis of isolated prostate secret. The initial samples were taken on the territory of the Irkutsk region from men diagnosed with chronic bacterial prostatitis in the acute stage. 90 % of samples of isolated prostate secret were tested by cultural method revealed 4l representatives of opportunistic pathogenic microflora. Gram-positive microorganisms were found in most samples (86.7 %). Staphylococcus genus representatives formed the majority in isolated samples of conditionally pathogenic microflora (66.7 %). As for gram-negative representatives (which role in chronic bacterial prostatitis is proven by multiple research), E. coli and K. pneumoniae were isolated. In the half of samples, we revealed bacterial associations consisting mostly of two kinds of microorganisms. Staphylococcus epidermidis was isolated in 70 % of such associations

Mobile technologies in implementation of programs of internal tourism development

Now a days great attention is paid to the programs of the development of domestic tourism, its informational support, the development of new tourist products. But in spite of efforts in this direction, the population of Russia still has not enough information about tourist recreational opportunities of particular regions and in the whole countr

The influence of virtual information spaces on tourism development

The desire to meet the requirements of the consumer necessitates the study of the influence of modern information and communication technologies on the development of the tourism industry by operators. The urgency of creating a virtual tourist information system, and developing its structure is required in order to match the innovative processes that involve modern technologies of Virtual and Augmented Realit