Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients

Background: The use of stem cells, including mesenchymal stem cells (MSCs), for regenerative medicine is gaining interest for the clinical benefits so far obtained in patients. This study investigates the use of adipose autologous tissue in combination with platelet-rich plasma (PRP) to improve the clinical outcome of patients affected by systemic sclerosis (SSc). Methods: Adipose-derived mesenchymal stem cells (AD-MSCs) and PRPs were purified from healthy donors and SSc patients. The multilineage differentiation potential of AD-MSCs and their genotypic-phenotypic features were investigated. A cytokine production profile was evaluated on AD-MSCs and PRPs from both healthy subjects and SSc patients. The adipose tissue-derived cell fraction, the so-called stromal vascular fraction (SVF), was coinjected with PRP in the perioral area of SSc patients. Results: Histopathological and phenotypical analysis of adipose tissue from SSc patients revealed a disorganization of its distinct architecture coupled with an altered cell composition. Although AD-MSCs derived from SSc patients showed high multipotency, they failed to sustain a terminally differentiated progeny. Furthermore, SVFs derived from SSc patients differed from healthy donors in their MSC-like traits coupled with an aberrant cytokine production profile. Finally, the administration of PRP in combination with autologous SVF improved buccal's rhyme, skin elasticity and vascularization for all of the SSc patients enrolled in this study. Conclusions: This innovative regenerative therapy could be exploited for the treatment of chronic connective tissue diseases, including SSc

Elevated Levels of Procalcitonin and Interleukin-6 are Linked with Postoperative Complications in Cardiac Surgery

Cardiac surgery-associated acute kidney injury is a frequent and serious postoperative complication of cardiac surgery and is associated with an increased risk of morbidity, mortality, and length stay. In this study, we hypothesized that persistent elevation in inflammation in the first 48\u2009h might be a powerful predictor of clinical outcome. Our aim was to elucidate the usefulness of interleukin-6 and procalcitonin postoperative levels in predicting mortality and renal complications in cardiac surgery patients

Le variet\ue0 di grano duro per le semine 2015. Dettaglio regionale dei risultati: Sicilia

Le 4 prove di confronto varietale condotte in Sicilia, con il coordinamento del Crea, sono state allestite in 4 diversi ambienti: Libertinia (Catania), Cammarata e S. Stefano Quisquina (Agrigento), e Catania. Fra le cultivar in prova per 4 an- nate in 15 differenti condizioni ambientali, Monastir e Ramirez hanno mostrato le migliori rese e la maggiore stabilita\u2019 produttiva, seguite da Anco Marzio, Saragolla, Alemanno, Kanakis, Iride, Tirex e Core. Fra le varieta\u2019 in prova nel triennio 2013-2015 e nell\u2019ultimo biennio, Emilio Lepido, Antalis e Asterix confermano elevata adattabilita\u2019 e buona stabilita\u2019 produttiva negli ambienti siciliani

Peritoneal carcinomatosis.

Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity. The occurrence of peritoneal carcinomatosis (PC) has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal cancer. During the last three decades, the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread, and the understanding of the protective function of the peritoneal barrier against tumoral seeding, has prompted the concept that PC is a loco-regional disease: in absence of other systemic metastases, multimodal approaches combining aggressive cytoreductive surgery, intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease, and ultimately to increase survival. The aim of this review article is to present the evidence on treatment of PC in different tumors, in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease

Pessima annata produttiva per l\u2019orzo zootecnico.

Fattori climatici e malattie crittogamiche hanno inciso pesantemente sulle prove realizzate, in particolare in alcuni areali. La produzione \ue8 risultata inferiore rispetto agli anni precedenti, con sole 5,5 t/ha in media al Nord, 5,3 al Centro e 4,5 t/ha al Sud e Isol

Campagna 2018 da dimenticare per l\u2019orzo da birra.

Il 2018 \ue8 stato un anno sfavorevole per la coltura dell\u2019orzo, in particolare per quanto riguarda la coltura primaverile. La media produttiva al Centro-Sud in semina autunnale \ue8 stata di 4,7 t/ha, mentre quella primaverile al Centro-Nord di sole 3 t/ha

Variet\ue0 di orzo zootecnico: bene al Sud, meno al Nord

Al Nord la media dell' areale \ue8 stata di 6,5 t/ha in ripresa rispetto al tracollo della scorsa annata, al Centro \ue8 risultata di sole 5,1 t/ha, dato al di sotto delle potenzialit\ue0 produttive; al Sud la produttivit\ue0 media \ue8 stata di 5,7 t/ha, un ottimo risultato che riporta l' areale su livelli elevat