The Galactic Isotropic γ\gamma-ray Background and Implications for Dark Matter

We present an analysis of the radial angular profile of the galacto-isotropic (GI) $\gamma$-ray flux--the statistically uniform flux in circular annuli about the Galactic center. Two different approaches are used to measure the GI flux profile in 85 months of Fermi-LAT data: the BDS statistic method which identifies spatial correlations, and a new Poisson ordered-pixel method which identifies non-Poisson contributions. Both methods produce similar GI flux profiles. The GI flux profile is well-described by an existing model of bremsstrahlung, $\pi^0$ production, inverse Compton scattering, and the isotropic background. Discrepancies with data in our full-sky model are not present in the GI component, and are therefore due to mis-modeling of the non-GI emission. Dark matter annihilation constraints based solely on the observed GI profile are close to the thermal WIMP cross section below 100 GeV, for fixed models of the dark matter density profile and astrophysical $\gamma$-ray foregrounds. Refined measurements of the GI profile are expected to improve these constraints by a factor of a few.Comment: 20 pages, 15 figures, references adde

Determination of Angle of Light Deflection in Higher-Derivative Gravity Theories

Gravitational light deflection is known as one of three classical tests of general relativity and the angle of deflection may be computed explicitly using approximate or exact solutions describing the gravitational force generated from a point mass. In various generalized gravity theories, however, such explicit determination is often impossible due to the difficulty with obtaining an exact expression for the deflection angle. In this work, we present some highly effective globally convergent iterative methods to determine the angle of semiclassical gravitational deflection in higher- and infinite-derivative formalisms of quantum gravity theories. We also establish the universal properties that the deflection angle always stays below the classical Einstein angle and is a strictly decreasing function of the incident photon energy, in these formalisms.Comment: 32 pages, 8 figure

Additional file 1: Table S1. of Comparative genomic analysis of Acinetobacter strains isolated from murine colonic crypts

Sequence of primers used for identification of the strains based on the sequences of 16S rRNA and recA. (DOCX 33 kb

Supplemental Data for "A validated pangenome-scale metabolic model for the <i>Klebsiella pneumoniae </i>species complex."

SummaryThis figshare directory contains supplemental data for the publication "A validated pangenome-scale metabolic model for the Klebsiella pneumoniae species complex".DOI: https://doi.org/10.1101/2023.12.20.572682The KpSC pan v2 model can be found here: https://github.com/kelwyres/KpSC-pan-metabolic-modelAccess Bactabolize here: https://github.com/kelwyres/Bactabolize_________________________________________________________Supplementary dataMEMOTE-Reports.zip contains four MEMOTE reports for each reference model (iYL1228, iKp1289, KpSC pan v1 & KpSC pan v2).Raw-Growth-Assay-Data.zip contains the growth assay data as both summary .xlsx files for each condition, in addition to the raw Tecan OD600 values._________________________________________________________Strain-specific modelsiYL1228-strain-specific-models.zip contains strain-specific models generated for 507 isolates. The reaction and gene data for these models are summarised in iYL1228-reaction-presence-absence-matrix.csv and iYL1228-gene-presence-absence-matrix.csv respectively.iKP1289-strain-specific-models.zip contains strain-specific models generated for 507 isolates. The reaction and gene data for these models are summarised in iKp1289-reaction-presence-absence-matrix.csv and iKp1289-gene-presence-absence-matrix.csv respectively.KpSC-pan-v1-strain-specific-models.zip contains strain-specific models generated for 507 isolates. The reaction and gene data for these models are summarised in KpSC-pan-v1-reaction-presence-absence-matrix.csv and KpSC-pan-v1-gene-presence-absence-matrix.csv respectively.KpSC-pan-v2-strain-specific-models.zip contains strain-specific models generated for 507 isolates. The reaction and gene data for these models are summarised in KpSC-pan-v2-reaction-presence-absence-matrix.csv and KpSC-pan-v2-gene-presence-absence-matrix.csv respectively._________________________________________________________Binary data to accompany supplementary tablesBinary-Predicted-Growth-Phenotypes-to-accompany-Table-S4.xlsx contains binary growth predictions for each strain-specific model, which were used to inform the data contained in Table S4. Aerobic-Carbon-Model-Predictions-to-accompany-Table-S6.xlsx contains binary aerobic growth phenotype data and accuracy classifications for each strain-specific model, which were used to inform the data contained in Table S6.Anaerobic-Carbon-Model-Predictions-to-accompany-Table-S7.xlsx contains binary anaerobic growth phenotype data and accuracy classifications for each strain-specific model, which were used to inform the data contained in Table S7.</p

Additional file 4: Table S2. of Comparative genomic analysis of Acinetobacter strains isolated from murine colonic crypts

Distribution of the genes of A. modestus CM11G and A. radioresistens CM38.2 following the functional categories obtained following RAST annotations. (DOCX 73 kb

Additional file 2: Figure S1. of Comparative genomic analysis of Acinetobacter strains isolated from murine colonic crypts

Whole genome comparative alignment of A. radioresistens CM38.2. The genome sequence is presented horizontally with the scale showing the sequence coordinates and the conserved shared synteny represented as the colored blocks which are connected across genomes. Upper panel: PacBio sequencing; lower panel: Illumina paired-end sequencing. (PDF 80 kb

CRISPR sizing by PCR for the rapid comparison of <i>Salmonella</i> spp isolates.

<p>Results of PCR amplification for 8 <i>S. enterica</i> serotype Typhimurium isolates collected from the same city during a single week (cluster E in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036995#pone.0036995.s009" target="_blank">Table S7</a>). Three cases were from the same food poisoning cluster (the food isolate was also tested), whereas the other cases were unrelated.</p

Primers used for the spacer content inventory.

1<p>Degenerate positions: R = G or A; Y = T or C; M = A or C; K = G or T; D = G or A or T; B = G or T or C.</p>2<p>AE006468, serotype Typhimurium LT2 strain; AE014613, serotype Typhi Ty2 strain.</p>3<p>The primer pairs used for CRISPR1 amplification for each of the 744 strains are indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036995#pone.0036995.s004" target="_blank">Table S2</a>.</p

Overview of the bead-based CRISPOL assay for <i>S. enterica</i> serotype Typhimurium developed here.

<p>The estimated time for each step is based on the testing of 65 isolates in a 96-well plate. The amplification step spans from the preparation of thermolysates to the gel electrophoresis of PCR products.</p

CRISPR1 spacer content in various O:9 and O:2 serotypes.

1<p>ST (sequence type) 11 group consists of ST11 and its single-locus variants (SLV).</p>2<p>Includes the 5 ST136 “Danysz”» strains used as rodenticides.</p>3<p>Ent20−//−Ent35, 15 unique spacers are located between Ent20 and Ent35 (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036995#pone.0036995.s004" target="_blank">Table S2</a>).</p>4<p>Serotype Gallinarum biovar Duisburg is different from serotype Duisburg.</p