Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

SummaryWe report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine

Using I-O Psychology to Improve the Plight of Women in Developing Countries: A Research Agenda

This chapter presents research questions emanating from descriptions of three Nicaraguan work situations—a microenterprise development program, garment assembly factories, and a coffee plantation—as well as those that emerged from Schein’s study of women and work groups in Nicaragua. These questions form the basis of an I-O research agenda for understanding the issues of women and work in developing countries

Women, Work and Poverty: Reflections on Research for Change

This chapter describes a new research approach-- social advocacy research-- and presents it as a good fit with the poverty and social change interests of the emerging field of humanitarian work psychology. Based on examples from her research studies of low income women in the US and Nicaragua, Schein illustrates the key features of social advocacy research. These characteristics include experiential idea generation, compassion in context, and research for change