Linear regression analyses with telomerase activity as the dependent variable (n = 217).

<p>MDS = Mediterranean Diet Score calculated as low = 1, medium = 2, high = 3.</p><p>Gender calculated as female = 0, male = 1.</p><p>Smoking habit calculated as non smoker = 0, former smoker = 1, current smoker = 2.</p

Correlation between LTL and telomerase activity in all population study.

<p>Partial correlations (r = 0.208; p = 0.002) between Leukocyte Telomere Length (LTL) and PBMC telomerase activity in all study population (n = 217), adjusted by gender, age and smoking habit.</p

LTL and Telomerase Activity according Mediterranean Diet Score subgroups.

<p>Data are means ± standard deviation. MDS≤3: n = 70; MDS 4–5: n = 68; MDS≥6: n = 79. <i>p</i> values were obtained using ANOVA followed by Bonferroni multiple testing correction. A) *p = 0.003; MDS≥6 vs MDS≤3 p = 0.009 and MDS≥6 vs MDS 4–5 p = 0.011 B) *p = 0.013; MDS≥6 vs MDS≤3 p = 0.028 and MDS≥6 vs MDS 4–5 p = 0.033. LTL, Leukocyte Telomere Length; MDS, Mediterranean Diet Score.</p

Characteristics of study population (n = 217) according to Mediterranean Diet Score.

<p>Data are means ± standard deviation.</p><p><i>p</i> values were obtained using χ² test* or ANOVA.</p

Crash percent stratified by tertiles of comorbidity index among the two age of current driver groups.

<p>Drivers <70 (n = 176): C1 = 99 (10.1%), C2 = 50 (26%), C3 = 27 (37%); χ² = 5.885, p = .048. Drivers >70 (n = 151): C1 =  28 (32.1%), C2 = 62 (27.4%), C3 = 61 (24.5%); χ² = 0.633, p = .729.</p

Percent of current drivers stratified by tertiles of comorbidity index among the two age groups.

<p>Drivers <70 (n = 176): C1 = 99 (96.1%), C2 = 50 (100%), C3 = 27 (100%); χ² = 1.543, p = .462. Drivers >70 (n = 151): C1 =  28 (73.6%), C2 = 62 (82.6%), C3 = 61 (62.8%); χ² =  7.301, p = .026.</p

Binary logistic regression analyses with crash involvement as dependent variable in younger drivers population study (n = 176).

<p>Comorbidity and severity indices expressed in tertiles.</p><p>Driving exposure expressed as low = 1, medium = 2, high  = 3 distance traveled.</p

Sample characteristics (n = 562).

<p>CIRS-SI =  Cumulative Illness Rating Scale-Severity Index; CIRS-CI =  Cumulative Illness Rating Scale-Comorbidity Index. Crashes number over the last 5 years. <i>p</i> = >70 years vs <70 years.</p