3,668 research outputs found
Letter to the editor: autoimmune pathogenic mechanisms in amyotrophic lateral sclerosis
The innate immune system may affect the function and survival of motor neurons in ALS by at least three mechanisms. First, there is evidence to suggest that aggregates of mutant SOD1—which is derived from microglial and astroglial cells—activate neighbouring microglia by binding to TLR2, TLR4, and CD14, and subsequently promote neuronal cell death [9]. Second, the release of pro- inflammatory cytokines may drive motor neuron damage. Third, although poorly understood, a mechanism has been suggested on the basis of the functional analysis of microglial cells that express mutant SOD1 [10]. These cells showed impaired overall motility and a reduced capacity to clear neuronal cell debris. Impairment of microglial cell phagocytosis may therefore contribute to the accumulation of further immunostimulatory proteins, including mutant SOD1, chromogranin A, and dsRNA, thereby resulting in disease progression
Locked in Functions: A Short Poem for Robert Langlands
This short poem is inspired by Robert Langlands, recipient of the 2018 Abel Prize. The poem tries to sum up in poetic language, as brief but substantial as it can be, the philosophical and rhetorical connotation of his contributions to mathematics, from automorphic forms to number theory, and the famous Langlands programme, among others. Also partly inspired by Edward Frenkel\u27s tribute to Langlands, the book Love and Mathematics, the poem seeks to capture the philosophical beauty of mathematics that privileges the importance of \u27functions\u27 over \u27passions\u27, consistent with Langlands\u27 purely mathematical side
Estimating Relevant Portion of Stability Region using Lyapunov Approach and Sum of Squares
Traditional Lyapunov based transient stability assessment approaches focus on
identifying the stability region (SR) of the equilibrium point under study.
When trying to estimate this region using Lyapunov functions, the shape of the
final estimate is often limited by the degree of the function chosen, a
limitation that results in conservativeness in the estimate of the SR. More
conservative the estimate is in a particular region of state space, smaller is
the estimate of the critical clearing time for disturbances that drive the
system towards that region. In order to reduce this conservativeness, we
propose a methodology that uses the disturbance trajectory data to skew the
shape of the final Lyapunov based SR estimate. We exploit the advances made in
the theory of sum of squares decomposition to algorithmically estimate this
region. The effectiveness of this technique is demonstrated on a power systems
classical model.Comment: Under review as a conference paper at IEEE PESGM 201
Interferometric length metrology for the dimensional control of ultra-stable Ring Laser Gyroscopes
We present the experimental test of a method for controlling the absolute
length of the diagonals of square ring laser gyroscopes. The purpose is to
actively stabilize the ring cavity geometry and to enhance the rotation sensor
stability in order to reach the requirements for the detection of the
relativistic Lense-Thirring effect with a ground-based array of optical
gyroscopes. The test apparatus consists of two optical cavities 1.32 m in
length, reproducing the features of the ring cavity diagonal resonators of
large frame He-Ne ring laser gyroscopes. The proposed measurement technique is
based on the use of a single diode laser, injection locked to a frequency
stabilized He-Ne/Iodine frequency standard, and a single electro-optic
modulator. The laser is modulated with a combination of three frequencies
allowing to lock the two cavities to the same resonance frequency and, at the
same time, to determine the cavity Free Spectral Range (FSR). We obtain a
stable lock of the two cavities to the same optical frequency reference,
providing a length stabilization at the level of 1 part in , and the
determination of the two FSRs with a relative precision of 0.2 ppm. This is
equivalent to an error of 500 nm on the absolute length difference between the
two cavities
A 1.82 m^2 ring laser gyroscope for nano-rotational motion sensing
We present a fully active-controlled He-Ne ring laser gyroscope, operating in
square cavity 1.35 m in side. The apparatus is designed to provide a very low
mechanical and thermal drift of the ring cavity geometry and is conceived to be
operative in two different orientations of the laser plane, in order to detect
rotations around the vertical or the horizontal direction. Since June 2010 the
system is active inside the Virgo interferometer central area with the aim of
performing high sensitivity measurements of environmental rotational noise. So
far, continuous not attempted operation of the gyroscope has been longer than
30 days. The main characteristics of the laser, the active remote-controlled
stabilization systems and the data acquisition techniques are presented. An
off-line data processing, supported by a simple model of the sensor, is shown
to improve the effective long term stability. A rotational sensitivity at the
level of ten nanoradiants per squareroot of Hz below 1 Hz, very close to the
required specification for the improvement of the Virgo suspension control
system, is demonstrated for the configuration where the laser plane is
horizontal
Lotta alla mosca delle olive in olivicoltura integrata e biologica
Bactrocera oleae, fitofago chiave dell’agroecosistema olivo, è presente in Italia in tutti gli areali interessati dalla coltura, tranne in alcune aree caratterizzate da maggiore altitudine dove il fattore termico non consente lo sviluppo della specie. Il dittero è fortemente legato alle temperature che del resto condizionano anche la fenologia dell’olivo; in effetti il numero di generazioni che la mosca può completare nell’anno varia da 1 fino a 4-5 in zone con temperature medie annue elevate (zone costiere e/o meridionali). La pericolosità della specie è pertanto legata al numero di generazioni e all’andamento climatico che, a seconda dell’annata e della zona, possono variare sensibilmente condizionando la densità di popolazione e quindi il grado di dannosità potenziale del fitofago. Recenti ricerche sul comportamento e sulla biologia del tefritide hanno messo in evidenza come il fitofago, nel tempo, abbia contratto con i batteri una simbiosi mutualistica che permette al dittero di aumentare il proprio potenziale biotico. Nel presente articolo, dopo un breve excursus sulla biologia e sui danni causati dal fitofago, viene fatto il quadro delle attuali strategie di lotta ammesse nei protocolli dell’olivicoltura integrata e biologica.The control of the olive fruit fly in integrated and organic olive crops. Bactrocera oleae (Rossi) is the key pest of the olive agroecosystem; it is distributed in all Italian olive crops, except in some areas at higher altitude where low temperatures do not allow the development of the fly. The olive fruit fly development is strictly affected by temperature. It can complete from one up to five generations per year in areas with high annual average temperature (coastal and/ or southern areas). The harmfulness of the species is related to the number of generations and weather conditions which may fluctuate considerably year by year, region by region. Recent researches on behavior and natural history of the tephritid fly have pointed out that it has developed a mutualistic symbiosis with bacteria which allows an increase of its growth rate. In this article authors present control strategies permitted in integrated and organic olive crops.
The currently widespread early harvesting and timely milling reduce the harmful influence of late olive fruit fly infestations; together with mass trapping and with repellent/ oviposition deterrent sprays by copper products and clays, these practices allow an increasingly sustainable effective
control of the olive fruit fl
Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's disease
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