Noise induced hearing loss: the role of oxidative stress

Introduction: Noise-induced hearing loss (NIHL) is a relevant source of hearing disability affecting the general population, and accounts for about 16% of all the reported cases of disabling hearing loss in the adult population worldwide. NIHL can follow workplace-related and recreational noise exposure, and can be influenced by individual factors such as age, sex, genetic predisposition and socio-economic factors. Objectives: The aim of this paper is to provide a quick overview of the principal ndings in noise induced hearing loss, focusing on the role of oxidative stress and antioxidant intervention. Review: Oxidative stress plays a central role in leading to a condition of NIHL. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) largely participate in cellular mechanisms that underlie mainly the outer hair cell death after noise exposure and lead to sensorineural hearing loss. The beneficial effects of antioxidant supplementation have been demonstrated by several experimental studies in animals, while the observed results in humans are mixed. Conclusion: NIHL still represents a widespread condition among the general population; with a higher prevalence in developing countries among workers, and in developed countries among young adults exposed to leisure noise. Extensive literature confirms that increasing antioxidant levels in the organ of Corti may be an appropriate approach towards understanding NIHL in humans by increasing the endogenous antioxidant response or by administering antioxidant molecules systemically or locally

Charmed Hadrons from Coalescence plus Fragmentation in relativistic nucleus-nucleus collisions at RHIC and LHC

In a coalescence plus fragmentation approach we calculate the heavy baryon/meson ratio and the $p_T$ spectra of charmed hadrons $D^{0}$, $D_{s}$ and $\Lambda_{c}^{+}$ in a wide range of transverse momentum from low $p_T$ up to about 10 GeV and discuss their ratios from RHIC to LHC energies without any change of the coalescence parameters. We have included the contribution from decays of heavy hadron resonances and also the one due to fragmentation of heavy quarks which do not undergo the coalescence process. The coalescence process is tuned to have all charm quarks hadronizing in the $p_T\rightarrow 0$ limit and at finite $p_T$ charm quarks not undergoing coalescence are hadronized by independent fragmentation. The $p_T$ dependence of the baryon/meson ratios are found to be sensitive to the masses of coalescing quarks, in particular the $\Lambda_{c}/D^{0}$ can reach values of about $\rm 1\div 1.5$ at $p_T \approx \, 3$ \mbox{GeV}, or larger, similarly to the light baryon/meson ratio like $p/\pi$ and $\Lambda/K$, however a marked difference is a quite weak $p_T$ dependence with respect to the light case, such that a larger value at intermediate $p_T$ implies a relatively large value also for the integrated yields. A comparison with other coalescence model and with the prediction of thermal model is discussed.Comment: 13 pages, 9 figures. Fig. 5 updated and some minor changes in the tex

Heavy Flavor Production, Flow and Energy Loss

Abstract An overview of the current status of the heavy quarks as probe of the hot QCD in-medium interaction is presented. Heavy quarks that produced out-of-equilibrium but strongly interacting with the created quark-gluon plasma (QGP) bulk medium offer the unique opportunity to have a probe that thermalize in a time scale comparable with the lifetime of the QGP. Finally, the possible role of heavy quark for probing the initial strong electromagnetic field created in relativistic heavy-ion collisions is discussed

Impact of off-shell dynamics on the transport properties and the dynamical evolution of Charm Quarks at RHIC and LHC temperatures

We evaluate drag and diffusion transport coefficients comparing a quasi-particle approximation with on-shell constituents of the QGP medium and a dynamical quasi-particles model with off-shell bulk medium at finite temperature T. We study the effects of the width $\gamma$ of the particles of the bulk medium on the charm quark transport properties exploring the range where $\gamma < M_{q,g}$. We find that off-shell effects are in general quite moderate and can induce a reduction of the drag coefficient at low momenta that disappear already at moderate momenta, $p \gtrsim 2-3\, \rm GeV$. We also observe a moderate reduction of the breaking of the Fluctuation-Dissipation theorem (FDT) at finite momenta. Moreover, we have performed a first study of the dynamical evolution of HQ elastic energy loss in a bulk medium at fixed temperature extending the Boltzmann (BM) collision integral to include off-shell dynamics. A comparison among the Langevin dynamics, the BM collisional integral with on-shell and the BM extension to off-shell dynamics shows that the evolution of charm energy when off-shell effects are included remain quite similar to the case of the on-shell BM collision integral.Comment: 13 pages, 14 figure