Patient disposition flow diagram.

<p>Patient disposition flow diagram showing patients included, excluded or lost-to-follow-up within the study cohort. MS: Multiple Sclerosis; RRMS: Relapsing-Remitting Multiple Sclerosis.</p

Kaplan-Meier curves for the probability of relapse occurrence, of 1-point EDSS progression, of reaching of EDSS 4.0, of reaching of EDSS 6.0, and of SP conversion, in relation to annual healthcare costs before the specific study endpoint was reached.

<p>Kaplan-Meier plots estimating the probability of relapse occurrence (<b>A</b>), of experiencing 1-point EDSS progression (<b>B</b>), of reaching of EDSS 4.0 (<b>C</b>), of reaching of EDSS 6.0 (<b>D</b>), and of SP conversion (<b>E</b>), in relation to the annual healthcare costs before the specific study endpoint was reached. P-values and hazard ratios (HR) are shown from time varying Cox regression models. For graphical purposes, healthcare costs have been categorized on the median value (the red line represents costs lower than the median value, whereas the blue line represents costs higher than the median value). EDSS: Expanded Disability Status Scale; HR: Hazard Ratio.</p

Scatter plot for overall annual healthcare costs and relapses.

<p>Scatter plot showing the relationship between overall annual healthcare costs and the ARR. P-value and coefficient from Poisson regression analysis are shown; 95% confidence intervals are represented in grey shadow. ARR: Annualised Relapse Rate; Coef: Coefficient.</p

Demographic features, clinical findings and healthcare costs.

<p>Demographic features, clinical findings and annual healthcare costs for DMT administration and management.</p

Healthcare costs for MS treatment and the rate of relapse occurrence, of 1-point EDSS progression, of reaching of EDSS 4.0, of reaching of EDSS 6.0, and of SP conversion.

<p>Healthcare costs for DMT administration and management before the specific endpoint was reached (considered as continuous variables), have been associated with the rate of relapse occurrence, of 1-point disability progression, of reaching of EDSS 4.0, of reaching of EDSS 6.0, and of SP conversion during the follow-up period. P-values, hazard ratios (HR), and 95% confidence intervals (95%CI) are shown from time varying Cox regression models, subsequently adjusted for age, gender, disease duration, and baseline EDSS.</p

Parameters of time intensity curve in Healthy Controls (HCs). CIS and patients with MS.

<p>* Kruskal-Wallis analysis of variance.</p><p>All results are expressed for veins only the lower wash-out rate was evaluated for patients and calculated as the lowest value between the IJV for each patient.</p

Authors' Response to the Letter to the Editor Regarding: A Comprehensive Review on Copemyl®

<p></p><p>Full copyright for enhanced digital features is owned by the authors.</p> <p> </p> <p><strong>Article full text</strong></p> <p><br> The full text of this article can be found <a href="https://link.springer.com/article/10.1007/s40120-018-0116-x"><b>here</b>.</a> <br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact <u>[email protected]</u>.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides</p><p></p

Parameters of time intensity curve in Healthy Controls (HCs). CIS and patients with MS.

<p>* Kruskal-Wallis analysis of variance.</p><p>All results are expressed for veins only the lower wash-out rate was evaluated for patients and calculated as the lowest value between the IJV for each patient.</p

Graph of six time-intensity curves shape types (TIC).

<p>Type 1 shows slow enhancement followed by wash out phase; type 2 fast enhancement followed by wash out phase; type 3 fast enhancement followed by plateau phase; type 4 fast enhancement followed by gradual enhancement increase; type 5 fast enhancement followed by a short time wash out and by a second peak of enhancement; type 6 unclassified enhancement. Type 1–2 TIC shapes were considered indicative of fast wash-out. Type 3-4-5 were considered indicative of a slow venous wash-out.</p

A Comprehensive Review on Copemyl®

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s40120-017-0079-3">https://link.springer.com/article/10.1007/s40120-017-0079-3</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p