20 research outputs found

    Predictive value of HCV RNA results in the CTM and ART at week 4 (a) and week 8/12 (b) after start of therapy with a protease inhibitor.

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    <p>TND  =  target not detected; DET  =  HCV RNA detected; TND/TND  =  HCV not detected in both assays; TND/DET  =  HCV RNA detected by only one assay; DET/DET: HCV RNA detected by both assays. *Patients with unavailable virological treatment outcome were excluded from analysis.</p

    Measured HCV RNA level by the ART and CTM in samples obtained 24 weeks after TVR/BOC therapy with a detectable HCV RNA in at least one of the two assays.

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    <p>The discordant results in ten samples (“TVR 4–6” and “BOC 18–24”) would have led to different treatment decisions (treatment discontinuation due to detectable HCV RNA). In a single sample the ART measured a higher HCV RNA level than the CTM (“BOC 5”).</p><p>Measured HCV RNA level by the ART and CTM in samples obtained 24 weeks after TVR/BOC therapy with a detectable HCV RNA in at least one of the two assays.</p

    HCV RNA levels according to ART and CTM in samples obtained 12 weeks after TVR treatment that yielded levels ≥50 IU/ml in at least one of the two assays.

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    <p>The discordant results in one sample (“TVR 3”) would have led to a different treatment decision (treatment discontinuation based on HCV RNA levels>1000 IU/ml at week 4).</p><p>HCV RNA levels according to ART and CTM in samples obtained 12 weeks after TVR treatment that yielded levels ≥50 IU/ml in at least one of the two assays.</p

    HCV RNA levels according to ART and CTM in samples obtained 4 weeks after start of TVR/BOC therapy that yielded levels ≥50 IU/ml in at least one of the two assays.

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    <p>The discordant results in two samples (“TVR 1” and “TVR 2”) would have led to different treatment decisions (treatment discontinuation based on HCV RNA levels>1000 IU/ml at week 4). In a single sample the ART measured a higher HCV RNA level than the CTM (“TVR 8”).</p><p>HCV RNA levels according to ART and CTM in samples obtained 4 weeks after start of TVR/BOC therapy that yielded levels ≥50 IU/ml in at least one of the two assays.</p
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