Reading the Transformations of an Urban Edge: From Liberty Era Palermo to the City of Today

To honour the battle of 27 May 1860, in 1910 the Palermo City Government decided to realise a commemorative monument. A position at the centre of a large circular plaza was of have afforded the monument a greater solemnity. The commission for the Monument was awarded to Ernesto Basile. In 1927 the City Government decided to dedicate the monument to the Fallen and asked Basile to complete the monument adding an architectural backdrop. The first version of the new project was a fence that enveloped the entire square and the ring road, interrupted only by entrances near the streets flowing into the square, and dividing it into four sectors. The final design instead called for the realisation of a semi-circular exedra of columns interrupted at the centre by a large gate that allows access to the square and to the back of the monument. The successive development of the city engulfed the square in the midst of tall and anonymous buildings realised, beginning in the 1960s, without any order of relations, stripping the surrounding fabric of its identity. Through the survey of the today‘s configuration, the analysis of Basile‘s original drawings and the representation of the modifications made over time, this text proposes an original reading of the configuration of Piazza Vittorio Veneto and the Monument to the Fallen, in relation to important moments in its history, from its design to the present day. The three-dimensional models reproduce the monument and its surroundings at the time of its construction in 1910, based on the first version for its expansion (unbuilt), with the addition of the exedra from 1930 and in its current condition. The redesign and extrapolation of different views of the digital models also provided original images of use to new readings of the perception of this space

Education and Museum: Cultural Heritage and learning

Project description supported by Erasmus Plus KA2- The project proposal is connected to the promotion of initiatives, starting in primary school, for using ICT, the open educational resources and digital resources of cultural heritage for the improvement science learning. The experience and result

Developmental trajectories of internally and externally driven temporal prediction

The ability to generate temporal prediction (TP) is fundamental to our survival since it allows us to selectively orient our attention in time in order to prioritize relevant environmental information. Studies on adult participants showed that externally and internally driven mechanisms can be engaged to establish TP, both resulting in better behavioural performance. However, few studies on children have investigated the ability to engage internally and externally driven TP, especially in relation to how these mechanisms change across development. In this study, 111 participants (88 children between six and eleven years of age, and 23 adults) were tested by means of a simple reaction time paradigm, in which temporal cueing and neutral conditions were orthogonally manipulated to induce externally and internally driven TP mechanisms, as well as an interaction between the two. Sequential effects (SEs) relative to both tasks were also investigated. Results showed that all children participating in the study were able to implement both external and internal TP in an independent fashion. However, children younger than eight years were not able to combine both strategies. Furthermore, in the temporal cueing blocks they did not show the typically-observed asymmetric SE pattern. These results suggest that children can flexibly use both external and internal TP mechanisms to optimise their behaviour, although their successful combined use develops only after eight years of age

Signal transduction pathways in the clinical approach: where are we going?

invited editoria

The intestinal lymphatic system: Functions and metabolic implications

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last 2 decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. As its metabolic implications are gaining recognition, intestinal lymphatic biology is currently experiencing a surge in interest. This review describes current knowledge related to molecular control of intestinal lymphatic vessel structure and function. We discuss regulation of chylomicron entry into lymphatic vessels by vascular endothelial growth factors (VEGFs), hormones, transcription factors and the specific signaling pathways involved. The information covered supports the emerging role of intestinal lymphatics in etiology of the metabolic syndrome and their potential as a therapeutic target. Keywords: Lacteals, Lipid, VEGF Signaling, Endothelium, Obesit

Stability of the Recovery of Missing Samples in Derivative Oversampling

This paper deals with the problem of reconstructing a band-limited signal when a finite subset of its samples and of its derivative are missing. The technique used, due to P.J.S.G. Ferreira, is based on the use of a particular frame for band-limited functions and the relative oversampling formulas. We study the eigenvalues of the matrices arising in the procedure of recovering the lost samples, finding estimates of their eigenvalues and their dependence on the oversampling parameter and on the number of missing samples. When the missing samples are consecutive, the problem may become very ill-conditioned. We present a numerical procedure to overcome this difficulty, also in presence of noisy data, by using Tikhonov regularization techniques.Comment: 17 pages,8 figure

Art and Medicine: from anatomic studies to Visual Thinking Strategies

Over the centuries the collaboration between artists and doctors and the relationship between art and medicine disciplines have been documented. Since the '60s the discipline of medical humanities has been developed in order to enrich the studies in medical sciences with the humanities. In the belief that medicine is more than just a set of knowledge and technical skills, medical educators have considered important to include the humanities as art, literature, philosophy, ethics, history, in the curriculum of training a good doctor. Despite there are examples of previous use of art as part of the curricula of medicine as a tool to develop the cognitive skills of observation and description, there is a general consensus that the semiotic competence starts from a correct and deep observation, "clinical eye", using senses to diagnose disease. It can talk about "Visual Thinking Strategy" (VTS) in this context. The VTS provides a way to enable the observation of the work of art, the process of analysis, comparison and discussion with others that allows the medical student to acquire a method to be applied also in clinical activity, improving skills in patient examination, by implementing the problem solving and critical thinking, getting used to teamwork, stimulating empathy toward patient and respect for others (whether patient or colleague). The observation practice should be key thing for medical training and this theory can be an aid to improve clinical skills. A trial of VTS for medicine students connected to Semiotic Course in collaboration with the Galleria Borghese in Rome during last academic year was carried out at The Degree Course in Medicine of the Faculty of Medicine and Psychology of Sapienza University.Keywords:Medical humanities, art, Visual Thinking StrategiesIntroductionArt understood as 'Tèchne' could be described as the application of rules set and experiences elaborated by man, therefore the knowledge, in order to make objects or to depict images taken from reality or fantasy world. Medical Science is a discipline defined as Art in so far as it able to apply the knowledge, therefore the Science of the disease cure. Over the centuries these disciplines have developed many relationships, in fact, we have document of the cooperation between artists and doctors. Let’s think , in Classical Antiquity, when artists could learn anatomical features only through the observation of athletes in gymnasium. Anatomical features, still unknown to the doctors, who could not use, for example, the dissection of corpse because this practice was prohibited for religious reasons. They were able to “admire” the representation of muscles stretching through sculpture, an example is Myron's Discobolus.In Medicine field only Herophilus of Chalcedon and Erasistratus, in the third century B.C. carried out dissections of "live" human bodies (1) until 1241 when Federico II promulgated the edict that authorized and stimulated the use of cadavers by doctors. In 1316 Mondino de Liuzzi wrote "Anothomia" founding the first School of Human Anatomy in Europe. It will have to wait the Renaissance, with the birth of the "modern" medicine, to discover that also the artists were able to use the human bodies for their anatomical studies. The first known example was Il Pollaiolo www.sensesandsciences.co

Spatiotemporal Neurodynamics Underlying Internally and Externally Driven Temporal Prediction: A High Spatial Resolution ERP Study

Temporal prediction (TP) is a flexible and dynamic cognitive ability. Depending on the internal or external nature of information exploited to generate TP, distinct cognitive and brain mechanisms are engaged with the same final goal of reducing uncertainty about the future. In this study, we investigated the specific brain mechanisms involved in internally and externally driven TP. To this end, we employed an experimental paradigm purposely designed to elicit and compare externally and internally driven TP and a combined approach based on the application of a distributed source reconstruction modeling on a high spatial resolution electrophysiological data array. Specific spatiotemporal ERP signatures were identified, with significant modulation of contingent negative variation and frontal late sustained positivity in external and internal TP contexts, respectively. These different electrophysiological patterns were supported by the engagement of distinct neural networks, including a left sensorimotor and a prefrontal circuit for externally and internally driven TP, respectively

The Internationalization of Global Start-Ups: Understanding the Role of Serial Entrepreneurs

Using qualitative methodology, we aim to understand how serial entrepreneurs can foster the development of born-global ventures. We consider a born-global start-up as the final stage of the learning process for a serial entrepreneur, advancing propositions regarding the importance of prior entrepreneurial experience – in terms of knowledge acquisition, identification and exploitation of opportunities, social networks development – for bornglobal venture creation and growth. We verify that the serial entrepreneur’s previous entrepreneurial experiences could substitute for the lack of knowledge, opportunity recognition and social networks of a born-global start-up. Thus, we recognize the necessity of a shift in the unit of analysis, from born-global start-up to a global serial entrepreneur. Moreover, we suggest to follow a dynamic approach when the born-global start-up issue is discussed since we expect that the entrepreneur’s learning process evolves over time in relation to their quality of previous experiences.born-global, international new ventures, entrepreneurship, serial entrepreneur, internationalization, social network, entrepreneurial experience, opportunity identification, opportunity exploration, longitudinal case study.