31 research outputs found

    Live-streaming: will football fans continue to be more law abiding than music fans?

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    The compact disc was launched in 1982 and heralded a golden age of music industry profitability before extensions of the same digital revolution, in the form of file-sharing, began, in 1999, to undermine the very foundations of commercial mediation in recorded music. The parallels in English football run one decade behind, with subscription-based digital broadcasting of live matches kicking off in 1992. Much has been made of the successes and corruptions associated with the vast influx of revenues that have supposedly transformed English ‘elite’ football, but such discussions are premature at best. Ten years on from the advent of file-sharing in music, parallel technologies are emerging for the free transmission of live sporting events. This article suggests that the cultural differences that might have inhibited the uptake of such services amongst football fans, relative to music fans, have been eroded by the very hyper-commercialization of sport which digital media once helped to facilitate but which now threatens or promises to undermine

    IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential

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    Background: IdeS, a proteinase from Streptococcus pyogenes, cleaves immunoglobulin (Ig)G antibodies with a unique degree of specificity. Pathogenic IgG antibodies constitute an important clinical problem contributing to the pathogenesis of a number of autoimmune conditions and acute transplant rejection. To be able to effectively remove such antibodies is therefore an important clinical challenge. Methodology/Principal Findings: IdeS was found to specifically and efficiently cleave IgG in human blood in vitro (20 mg of IdeS caused a complete degradation of IgG in one ml of human whole blood in 15 minutes) and to clear IgG from the blood stream of rabbits in vivo (no IgG was detected six hours following an intravenous injection of 5 mg of IdeS) without any side effects. In a mouse model of immune thrombocytopenic purpura (ITP), polyclonal IgG antibodies against platelet surface antigens were used to induce a lethal disease. These profoundly thrombocytopenic animals were treated and cured by a single injection of IdeS. Conclusions/Significance: Novel information is provided concerning the IgG-cleaving activity of IdeS in vitro and in vivo. The highly specific and rapid elimination of IgG in vivo, the dramatic effect in a mouse model of ITP, and the lack of sid

    Some analyses of EC-135 aircraft model data : final report

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    http://deepblue.lib.umich.edu/bitstream/2027.42/6294/5/bad0390.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/6294/4/bad0390.0001.001.tx

    Diffraction, scattering and impedance loading : final report, September 1976-September 1972

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    http://deepblue.lib.umich.edu/bitstream/2027.42/7533/5/bad2171.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/7533/4/bad2171.0001.001.tx

    Analyses and Digital Programs for Computing the Monopulse Pointing Errors Associated with Three-Dimensional Conical and Ogival Radomes with or without a Surrounding (Weak) Plasma

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    http://deepblue.lib.umich.edu/bitstream/2027.42/21168/2/rl2043.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/21168/1/rl2043.0001.001.tx

    Modification to the scattering behavior of a sphere by reactive loading

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    http://deepblue.lib.umich.edu/bitstream/2027.42/6292/5/bad0377.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/6292/4/bad0377.0001.001.tx

    Non-Specular RAM

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    http://deepblue.lib.umich.edu/bitstream/2027.42/21399/2/rl2275.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/21399/1/rl2275.0001.001.tx
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