EPIDEMIOLOGIC STUDY OF ENDOMETRIAL LESION CHARACTERISTICS BY AGE IN PATHOLOGY DIAGNOSTIC CENTER IN SURABAYA 2015-2017

Background: The etiology of endometrial lesions varies from benign to malignant. Early detection and management of malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differed according to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of malignancy increased 4.39 times (p.00) beyond 50 years old

Drug eluting prosthetic joints through drug cluster morphology control

Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, 2017.Cataloged from PDF version of thesis.Includes bibliographical references (pages 299-330).More than one million joint replacements are performed in the USA annually. However, around 10 % of patients require revision surgery within 10 years with prosthetic joint infections (PJI) as a common reason. PJI has a recurrence rate of 16 %, a mortality rate of 2.5 %, and end-stage treatments involving arthrodesis and amputation. Most drug eluting polymers that were in development to address this problem failed due to toxic degradation products, insufficient drug release, and insufficient mechanical strength. The gold standard of treatment uses antibiotic eluting bone cement which has a mechanical failure rate of 26-60 % within 49-54 months if used under load bearing conditions. Therefore, despite advances in orthopedic materials, development of drug-eluting devices with effective, sustained delivery with the necessary mechanical strength for a fully load bearing joint implant has been elusive. Here, we report the synthesis and application of a drug eluting, fully load bearing, and articulating joint prosthesis that has superior mechanical strength and drug elution profile compared to the clinical gold standard, antibiotic eluting bone cement. We modified the eccentricity of drug clusters and percolation threshold in the polymeric matrix of Ultra-High Molecular Weight Polyethylene (UHMWPE), which resulted in maximized drug elution and mechanical strength retention. The optimized antibiotic eluting UHMWPE elutes antibiotic at a higher concentration for a longer period of time than antibiotic eluting bone cement while retaining the mechanical and wear properties of clinically used UHMWPE joint prosthesis. After drug elution, the empty drug clusters in the polymer were filled with biological lubricants during articulation, which through a combination of weeping and elastohydrodynamic lubrication, reduced the overall wear rate of the UHMWPE. Treatment of Staphylococcus aureus infected lapine knee with the antibiotic eluting UHMWPE showed complete bacterial eradication without any detectable systemic side effect. Taken together, our study showed that the drug-eluting UHMWPE joint implants in this study are promising candidates for further clinical trial and as the next generation prosthetic joints.by Vincentius Jeremy Suhardi.Ph. D. in Medical Engineering and Medical Physic

Epidemiologic study of endometrial lesion characteristics by age in pathology diagnostic center in surabaya 2015-2017

Background: The etiology of endometrial lesions varies from benign to malignant. Early detection and management of malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differedaccording to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of malignancy increased 4.39 times (p.00) beyond 50 years old

Epidemiologic Study of Endometrial Lesion Characteristics by Age in Pathology Diagnostic CENTER in Surabaya 2015-2017

Background: The etiology of endometrial lesions varies from benign to Malignant. Early detection and management of Malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of Malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial Malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differed according to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of Malignancy increased 4.39 times (p.00) beyond 50 years old

Correction to: At the US Epicenter of the COVID-19 Pandemic, an Orthopedic Residency Program Reorganizes.

[This corrects the article DOI: 10.1007/s11420-020-09765-5.]