What's best when a patient doesn't respond to the maximum dose of an antidepressant?

Consider possible causes of the inadequate response, then weigh treatment options in light of the characteristics of the individual patient and therapy. When managing a patient with nonpsychotic depression and inadequate response to the maximum dose of a single antidepressant, the physician should first identify factors that may contribute to the poor response, such as suboptimal dosage resulting from nonadherence, inadequate duration of therapy, and comorbid medical and psychiatric conditions (strength of recommendation [SOR]: C, expert opinion)

Almost partitioning every 22-edge-coloured complete kk-graph into kk monochromatic tight cycles

A $k$-uniform tight cycle is a $k$-graph with a cyclic order of its vertices such that every $k$ consecutive vertices from an edge. We show that for $k\geq 3$, every red-blue edge-coloured complete $k$-graph on $n$ vertices contains $k$ vertex-disjoint monochromatic tight cycles that together cover $n - o(n)$ vertices

Towards Lehel's conjecture for 4-uniform tight cycles

A $k$-uniform tight cycle is a $k$-uniform hypergraph with a cyclic ordering of its vertices such that its edges are all the sets of size $k$ formed by $k$ consecutive vertices in the ordering. We prove that every red-blue edge-coloured $K_n^{(4)}$ contains a red and a blue tight cycle that are vertex-disjoint and together cover $n-o(n)$ vertices. Moreover, we prove that every red-blue edge-coloured $K_n^{(5)}$ contains four monochromatic tight cycles that are vertex-disjoint and together cover $n-o(n)$ vertices.Comment: arXiv admin note: text overlap with arXiv:1606.05616 by other author

When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis?

Cyclo-oxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs (NSAIDs) are as effective as acetaminophen and nonselective NSAIDs in treating of osteoarthritis, and are equally effective in reducing pain and inflammation and improving of joint function for patients with rheumatoid arthritis, when compared with nonselective NSAIDs. The COX-2 selective NSAIDs also have a better gastrointestinal safety profile in short-term (6-12 month) treatment (strength of recommendation [SOR]: A, based on meta-analysis of randomized controlled trials withpatient-oriented outcomes)

Warfarin for Prevention of Ischemic Stroke Recurrence?

There is no evidence that anticoagulation with warfarin, initiated after a non- cardioembolic ischemic stroke, significantly reduces stroke recurrence. Furthermore, anticoagulation significantly increases the risk of fatal and nonfatal hemorrhagic stroke and extracranial hemorrhage in these patients. However, warfarin clearly is indicated for patients who have embolic strokes caused by underlying conditions such as atrial fibrillation or myxoma. (Strength of recommendation: A

Statin Therapy in Patients with Type 2 Diabetes

Based on current evidence, statin therapy should be offered to all patients with type 2 diabetes who are known to have coronary artery disease. [Strength of recommendation: A] For patients older than 40 years with type 2 diabetes who are not known to have cardiovascular disease, statins are recommended if other cardiovascular risk factors are present, regardless of the initial low-density lipoprotein (LDL) level, if the patient has failed to reach the target LDL goal of less than 100 mg per dL (2.6 mmol per L) by lifestyle modification for primary prevention. [Strength of recommendation: A

Antibiotic Prophylaxis to Prevent Recurrent UTI in Children

Antibiotic prophylaxis to prevent recurrent UTI may be considered in infants and children with or without vesicoureteral reflux (VUR) after a first UTI. (Strength of Recommendation [SOR]: B, based on inconsistent evidence from systematic reviews and one large randomized controlled trial [RCT]) The potential benefit of preventing recurrent UTI by antibiotic prophylaxis should be weighed against the risk of antimicrobial resistance with future infections. (SOR: B, based on inconsistent evidence from one systematic review and two RCTs) Accurate diagnosis of UTI followed by prompt treatment is recommended. (SOR: C, based on expert opinion