Additional file 1: of Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review

Word document (62 KB). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA statement. This file contains a 27-item checklist of recommended items to include in a systematic review and meta-analysis. (DOC 62 kb

Timeline of the patient's clinical course.

<p>Timeline is not to scale. Abbreviations: Ab: Antibody ANA: anti-nuclear antibody, ANCA: anti-neutrophil cytoplasmic antibody, BM Bx: bone marrow biopsy, CSF: cerebrospinal fluid, ED: Emergency department, ENA: extractable nuclear antigens, ESR: erythrocyte sedimentation rate, Hb: haemoglobin, LP: lumbar puncture, MRI: magnetic resonance imaging, NECT: nifurtimox-eflornithine combination therapy, NMDA: N-methyl-D-aspartate receptor, PEX: Plasma exchange, PCR: polymerase chain reaction, Plts: platelets, Rx: treated with, VGKC: complex voltage gated potassium channel-complex, WCC: white cell count.</p

Phylogenetic tree depicting the relationship between our patient's parasite and field isolates taken between 1978–1983.

<p>Neighbour joining tree of <i>T. b. brucei</i>, <i>T. b. gambiense</i> group 1 and <i>T. b. gambiense</i> group 2 isolates from Cote d'Ivoire and <i>T. b. gambiense</i> group 1 isolates from Cameroon and the Democratic Republic of Congo. Our patient's isolate clustered most closely with other Type 1 isolates from Cote d'Ivoire.</p

Map showing reports of spontaneous clearance of infection (blue squares), or extended duration of infection (red squares).

<p>Abbreviations: sc: spontaneous clearance of infection, y: years. References: <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003349#pntd.0003349-Todd1" target="_blank">[4]</a>–<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003349#pntd.0003349-Barlovatz1" target="_blank">[11]</a>. Adapted from <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003349#pntd.0003349-Checchi1" target="_blank">[3]</a>.</p