Extracellular Nucleic Acids in Blood of Patients with Chronic Obstructive Pulmonary Disease

The concentrations of extracellular nucleic acids and acid-soluble precursors of nucleic acids in blood of patients with different forms and severity of chronic obstructive pulmonary disease (COPD) were evaluated. The significant increase of the content of extracellular RNA and acid-soluble precursors of nucleic acids in plasma of patients with COPD was detected. The decrease of extracellular RNA in plasma of patients with COPD worsening was diagnosed. Extracellular DNA in plasma and red blood cells of patients didn’t change significantly. The article examines the mechanisms of extracellular nucleic acids increase in blood of COPD patients, studies the possible role of extracellular RNA in development of coagulation disorders in COPD patients. The further research of the role of extracellular nucleic acids and their precursors in COPD progression is require

Comparative Characteristics of Erythrocytes Charge Balance in Patients with Chronic Obstructive Pulmonary Disease

The aim of the investigation is studying of erythrocytes charge balance in patients with chronic obstructive pulmonary disease (COPD) of bronchitic and mixed types. The similar trend of change Δ pH of erythrocytes in patients with COPD was observed during the incubation of red blood cells in the range of 37-58 ˚C. The thermograms represented decreasing curve, Δ pH ranged from -0.326 to -0.453 (the average value was -0.383). During subsequent 20- minute incubation of erythrocyte suspension at 58 ˚C, two main types of thermal images, depending on the degree of respiratory failure were recorded. Possible mechanisms of the erythrocytes charge balance alterations in patients with COPD are discussed

The Protein Carbonyl Derivatives in Blood of Patients With Chronic Obstructive Pulmonary Disease

The protein carbonyl derivatives in plasma and erythrocyte of patients with chronic obstructive pulmonary disease (COPD) were studied. There were 2 groups: 16 patients with COPD and 17 healthy persons as control subjects. There were statistically significant decreasing of protein carbonyl derivatives in plasma and erythrocytes of patients with COPD. For explaining the decline of carbonyl derivatives in blood of COPD patients the hypothesis was put forwar

Purine Bases in Blood Plasma of Patients with Chronic Pulmonary Diseases

The article is focused on the study of purine bases and intermediates of purine catabolism in plasma of patients with chronic obstructive bronchitis and idiopathic interstitial pneumonia. Decrease of adenine and hypoxantine in plasma of patients with idiopathic interstitial pneumonia was registered. Increase of guanine in plasma of patients with chronic obstructive pulmonary disease was establishe

Purine Bases in Blood Plasma of Patients with Chronic Pulmonary Diseases

The article is focused on the study of purine bases and intermediates of purine catabolism in plasma of patients with chronic obstructive bronchitis and idiopathic interstitial pneumonia. Decrease of adenine and hypoxantine in plasma of patients with idiopathic interstitial pneumonia was registered. Increase of guanine in plasma of patients with chronic obstructive pulmonary disease was established