95 research outputs found
HRGC-MS analysis of terpenoids from Maytenus ilicifolia and Maytenus aquifolium ("espinheira santa")
Absence of mutagenic effect of Mikania glomerata hydroalcoholic extract on adult wistar rats in vivo
Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity.
Ethnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quinic acid, gallic acid, and methyl gallate showed lower antifungal effect compared with galloylquinic derivatives. In addition, the BF extract had no hemolytic effect and no toxicity on G. mellonella
Antimicrobial activity of essential oils from Pimenta pseudocaryophyllus and Tynanthus micranthus
Chemical review and studies related to species from the genus Tynanthus (Bignoniaceae)
Isolation and HPLC quantitative analysis of new flavonoid tetraglycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium).
Coumarins and terpenoids from Dorstenia asaroides Gardn. in Hook
Phytochemical investigation of rhizomes and leaves of Dorstenia asaroides Gardn. in Hook. (Moraceae) afforded the furocoumarins psoralen and bergapten, the triterpenes α-amyrin, α-amyrin acetate, ÎČ-amyrin acetate, lupeyl acetate and simiarenol and saccharose
HRGC-MS analysis of terpenoids from Maytenus ilicifolia and Maytenus aquifolium ("espinheira santa")
This work describes the identification of some of the minor chemical constituents of "espinheira santa" (Maytenus ilicifolia and Maytenus aquifolium, Celastraceae), a medicinal plant widely utilized in Brazil. By using high resolution gas chromatography coupled to mass spectrometry (HRGC-MS), it was possible to identify mainly triterpenoids and steroids in "espinheira santa", most of them reported for the first time in both Maytenus species
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