A new technique to determine vertical dimension of occlusion from anthropometric measurement of interpupillary distance

Background: A number of techniques are being practiced for the evaluation of VDO, but none of them is scientifi - cally more accurate than other. Each method advocated has its own limitations. Objectives: The purpose of this study was to find correlation between vertical dimension of occlusion (VDO) and interpupillary distance (IPD). Material and Methods: A cross-sectional study was conducted on 400 dentate subjects comprising of 200 males and 200 females. Anthropometric measurement of VDO was recorded clinically using modified digital vernier caliper. Also, a standardized digital photograph of face was generated from the frontal aspect using a digital camera for the measurement of IPD in millimeters. Correlation between VDO and IPD was studied using Spearman's coefficient. For the execution of regression command and preparation of prediction equations to estimate VDO, Statistical Package for Social Sciences (SPSS) Software Version 11.5 was used. Results: VDO and IPD was more in males compared to females. VDO was significantly and positively correlated with IPD only in males whereas females showed a weak correlation. Hence, regression equation was derived only for males. VDO estimation using regression equation for IPD had a standard error of ± 3.94 in males. Conclusions: Since the variations between VDO and IPD are within the range of 2-4 mm, VDO prediction through this method is reliable and reproducible for male patients. Also, the method is simple, economic, and non invasive; hence it could be recommended for everyday practice to determine vertical dimension of occlusion in case of male patients

CFD-based Analysis & Correlation Development for a Novel Multi-furcating Heat Exchanger for High Temperature, High Pressure Applications

The thermal efficiency of indirectly heated power cycles such as supercritical carbon dioxide (sCO2) closed Brayton cycles are typically limited by their heat exchangers (HXs), which require high heat transfer effectiveness while operating for tens of thousands of hours under high temperature (\u3e800°C) and pressure (\u3e80 bar) conditions. Previous literature has shown that the use of nature-inspired furcating flow channels represents an exciting opportunity to improve HX thermal-hydraulic performance. In this paper, we analyze the novel multi-furcating HX manifold concept, that was previously shown experimentally to reduce HX volume and mass compared to a baseline oil cooler by 50% and 67%, respectively. Computational fluid dynamics (CFD) simulations are utilized to analyze thermal-hydraulic performance and fluid flow development. CFD-based correlations of Nusselt number and friction factor are developed for performance prediction of a full, additively manufactured HX. The developed Nusselt number and friction factor correlations predict unit cell thermal-hydraulic performance within ±3% and ±5% for all simulated Reynolds numbers, respectively. The full HX would enable increased thermal efficiency of indirectly heated power cycles to reduce both energy consumption and emissions while also allowing opportunities in advanced aerospace applications

Metabolic Alterations in Pancreatic Cancer Progression

Pancreatic cancer is the third leading cause of cancer-related deaths in the USA. Pancreatic tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor microenvironment and a resultant acidic milieu. The metabolic reprogramming allows cancer cells to survive hostile microenvironments. Through the analysis of the principal metabolic pathways, we identified the specific metabolites that are altered during pancreatic cancer progression in the spontaneous progression (KPC) mouse model. Genetically engineered mice exhibited metabolic alterations during PanINs formation, even before the tumor development. To account for other cells in the tumor microenvironment and to focus on metabolic adaptations concerning tumorigenic cells only, we compared the metabolic profile of KPC and orthotopic tumors with those obtained from KPC-tumor derived cell lines. We observed significant upregulation of glycolysis and the pentose phosphate pathway metabolites even at the early stages of pathogenesis. Other biosynthetic pathways also demonstrated a few common perturbations. While some of the metabolic changes in tumor cells are not detectable in orthotopic and spontaneous tumors, a significant number of tumor cell-intrinsic metabolic alterations are readily detectable in the animal models. Overall, we identified that metabolic alterations in precancerous lesions are maintained during cancer development and are largely mirrored by cancer cells in culture conditions

Acute tubulo-interstitial nephritis leading to acute renal failure following multiple hornet stings

BACKGROUND: Hornet stings are generally associated with local and occasionally anaphylactic reactions. Rarely systemic complications like acute renal failure can occur following multiple stings. Renal failure is usually due to development of acute tubular necrosis as a result of intravascular haemolysis, rhabdomyolysis or shock. Rarely it can be following development of acute tubulo-interstitial nephritis. CASE PRESENTATION: We describe a young male, who was stung on face, head, shoulders and upper limbs by multiple hornets (Vespa orientalis). He developed acute renal failure as a result of acute tubulo-interstitial nephritis and responded to steroids. CONCLUSION: Rare causes of acute renal failure like tubulo-interstitial nephritis should be considered in a patient with persistent oliguria and azotemia following multiple hornet stings. Renal biopsy should be undertaken early, as institution of steroid therapy may help in recovery of renal functio

A Unified Dual-view Model for Review Summarization and Sentiment Classification with Inconsistency Loss

Acquiring accurate summarization and sentiment from user reviews is an essential component of modern e-commerce platforms. Review summarization aims at generating a concise summary that describes the key opinions and sentiment of a review, while sentiment classification aims to predict a sentiment label indicating the sentiment attitude of a review. To effectively leverage the shared sentiment information in both review summarization and sentiment classification tasks, we propose a novel dual-view model that jointly improves the performance of these two tasks. In our model, an encoder first learns a context representation for the review, then a summary decoder generates a review summary word by word. After that, a source-view sentiment classifier uses the encoded context representation to predict a sentiment label for the review, while a summary-view sentiment classifier uses the decoder hidden states to predict a sentiment label for the generated summary. During training, we introduce an inconsistency loss to penalize the disagreement between these two classifiers. It helps the decoder to generate a summary to have a consistent sentiment tendency with the review and also helps the two sentiment classifiers learn from each other. Experiment results on four real-world datasets from different domains demonstrate the effectiveness of our model.Comment: Accepted by SIGIR 2020. Updated the results of balanced accuracy scores in Table 3 since we found a bug in our source code. Nevertheless, our model still achieves higher balanced accuracy scores than the baselines after we fixed this bu

The Burden of Human Papillomavirus Infections and Related Diseases in Sub-Saharan Africa

Despite the scarcity of high quality cancer registries and lack of reliable mortality data, it is clear that human papillomavirus (HPV)-associated diseases, particularly cervical cancer, are major causes of morbidity and mortality in sub-Saharan Africa (SSA). Cervical cancer incidence rates in SSA are the highest in the world and the disease is the most common cause of cancer death among women in the region. The high incidence of cervical cancer is a consequence of the inability of most countries to either initiate or sustain cervical cancer prevention services. In addition, it appears that the prevalence of HPV in women with normal cytology is higher than in more developed areas of the world, at an average of 24%. There is, however, significant regional variation in SSA, with the highest incidence of HPV infection and cervical cancer found in Eastern and Western Africa. It is expected that, due to aging and growth of the population, but also to lack of access to appropriate prevention services and the concomitant human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic, cervical cancer incidence and mortality rates in SSA will rise over the next 20 years. HPV16 and 18 are the most common genotypes in cervical cancer in SSA, although other carcinogenic HPV types, such as HPV45 and 35, are also relatively more frequent compared with other world regions. Data on other HPV-related anogenital cancers including those of the vulva, vagina, anus, and penis, are limited. Genital warts are common and associated with HPV types 6 and 11. HIV infection increases incidence and prevalence of all HPV-associated diseases. Sociocultural determinants of HPV-related disease, as well as the impact of forces that result in social destabilization, demand further study. Strategies to reduce the excessive burden of HPV-related diseases in SSA include age-appropriate prophylactic HPV vaccination, cervical cancer prevention services for women of the reproductive ages, and control of HIV/AIDS

The burden of cervical pre-cancer and cancer in HIV positive women in Zambia: a modeling study

Abstract Background HIV infection is associated with a higher incidence of precancerous cervical lesions and their progression to invasive cervical cancer (ICC). Zambia is a global epicenter of HIV and ICC, yet the overall burden of cervical pre-cancer [cervical intraepithelial neoplasia 3 (CIN3)] and ICC among its HIV positive adult female population is unknown. The objective of this study was to determine the burden of cervical disease among HIV positive women in Zambia by estimating the number with CIN3 and ICC. Methods We conducted a cross-sectional study among 309 HIV positive women attending screening in Lusaka (Zambia’s most populated province) to measure the cervical disease burden by visual inspection with acetic acid enhanced by digital cervicography (DC), cytology, and histology. We then used estimates of the prevalence of CIN3 and ICC from the cross-sectional study and Spectrum model-based estimates for HIV infection among Zambian women to estimate the burden of CIN3 and ICC among HIV positive women nationally. Results Over half (52 %) of the study participants screened positive by DC, while 45 % had cytologic evidence of high grade squamous intraepithelial lesions (SIL) or worse. Histopathologic evaluation revealed that 20 % of women had evidence of CIN2 or worse, 11 % had CIN3 or worse, and 2 % had ICC. Using the Spectrum model, we therefore estimate that 34,051 HIV positive women in Zambia have CIN3 and 7,297 have ICC. Conclusions The DC, cytology, and histology results revealed a large cervical disease burden in this previously unscreened HIV positive population. This very large burden indicates that continued scale-up of cervical cancer screening and treatment is urgently needed