OTKRIVANJE I KLASIFIKACIJA BOLESTI USJEVA NA TEMELJU INFORMACIJSKOG HIBRIDNOG PRISTUPA

The objective of this paper to identify the diseases in the leaves of the all plants. Plant disease diagnosis helps to improve both the quality and quantity of crop productivity. In existing, to detect the diseases they used the spectroscopic techniques. These techniques are very expensive and can only be utilized by trained persons only. This work proposes an approach for the detection of leaf diseases based on the characterization of texture, shape and color properties. The detection of diseases which are detected using ISRC(improved sparse Representation Classifier) technique. First the GENABC clustering approach is applied to the input image to segment the affected area. Then extract the features from the affected area by using feature extraction techniques. In this paper Improved Transform Encoded Local Pattern used to extract the texture feature, Enhanced Gradient Feature (EGF) to extract the shape and Improved Color Histogram Techniques(ICH) are used to extract the color. And then these features are given to the ISRC classifier to get the exact type of disease on affected leaves. To analyze the performance of the proposed method we use four metrics. They are classification accuracy, error rate, precision value and recall value. From the analysis of experimental results, the ISRC method provides the best result than the existing approach.Cilj ovog rada je identificirati bolesti u listovima svih biljaka. Dijagnoza biljnih bolesti pomaže poboljšati kvalitetu i količinu produktivnosti usjeva. Za otkrivanje bolesti koriste se spektroskopske tehnike. Te tehnike su vrlo skupe i mogu ih koristiti samo obučene osoba. Ovaj rad predlaže pristup za otkrivanje bolesti listova na temelju karakterizacije svojstava teksture, oblika i boja. Otkrivanje bolesti koje se detektiraju uporabom ISRC tehnike. Najprije se primjenjuje GENABC klastering pristup na ulaznu sliku za segmentiranje pogođenog područja. Zatim se ekstrahiraju značajke sa zahvaćene površine pomoću tehnika ekstrakcije značajki. U ovom se radu koristi poboljšana transformirana enkodirana lokalna shema koja se koristi za izdvajanje značajki teksture, poboljšane značajke gradijenata (EGF) za izdvajanje oblika i poboljšane tehnike hektologije boja (ICH) za izdvajanje boje. Zatim se ove značajke daju ISRC klasifikatoru kako bi dobili točnu vrstu bolesti na zahvaćenom lišću. Za analizu izvedbe predložene metode koristimo četiri metrike. To su točnost klasifikacije, stopa pogrešaka, preciznost i vrijednost opoziva. Iz analize eksperimentalnih rezultata ISRC metoda daje bolji rezultat od postojećeg pristupa

Evaluation of efficacy and safety of terbinafine and itraconazole in superficial mycoses: a prospective, randomized, controlled and cost-effective analysis study

Background: Superficial mycoses are common worldwide. Dermatophytic infections can greatly affect quality of life. Several newer antimycotic agents, have been reported effective and safe. Hence this study was planned to analyse effectiveness as well as cost effectiveness of these treatments.Methods: It were a prospective, randomized, parallel, open label, comparative study. Fifty patients were included in the study and divided into 2 groups. They were randomized to receive either oral terbinafine 250 mg or itraconazole 100 mg once daily for 4 weeks. Scaling, erythema and pruritus were rated as clinical score 0 to 3: 0 - absent, 1 - mild, 2 - moderate, and 3 - severe for the above three target symptoms. Total symptom score was assessed. Pruritus was also graded on visual analogue scale (VAS). Mycological cure was assessed by skin scraping with KOH mounts and fungal culture. Clinical efficacy scoring and VAS were assessed before the study and at each follow up visit at 2 and 4 weeks. Patients were followed up for another 4 weeks after completion of the treatment.Results: There was highly significant decrease p<000.1 in the mean total symptoms scores in both the study groups from baseline. No significant difference in the mean total symptoms score was observed when compared between groups. ADRs were more in terbinafine group.Conclusions: Both terbinafine and itraconazole are effective and safe against superficial mycoses, but adverse effects are more with terbinafine. Itraconazole was found to be cost effective compared to terbinafine

Glycosylated hemoglobin as an efficacious tool for early prediction of gestational diabetes mellitus

The incidence and prevalence of GDM is on the rise worldwide and, more so in developing countries including India. GDM is associated with maternal, fetal and neonatal morbidities. Current guidelines recommend GDM screening only at 24-28 weeks of gestation. Diagnosis of GDM in later half of pregnancy leads to fetal and maternal morbidities in spite of good glycemic control. This necessitates the use of a simpler, convenient, accurate, and reliable test, which can predict GDM in early gestation. Our article reviews the scope of using HbA1c for GDM and its efficacy in screening GDM

Attitudes of undergraduates towards mental illness: A comparison between nursing and business management students in India

Background. Mental illness is an important public health issue worldwide; stigmatisation and negative attitudes towards people with mental illness are widespread among the general public. However, little is known about the attitudes of undergraduates to mental illness.  Purpose. To compare the attitudes towards mental illness among undergraduates enrolled in nursing courses v. those enrolled in Bachelor of Business Management (BBM) courses.  Methods. A cross-sectional descriptive design was adopted for the present study. A total of 268 undergraduates were selected to complete the Attitude Scale for Mental Illness (ASMI) and the Opinions about Mental Illness in the Chinese Community (OMICC) questionnaires.  Results. We found significant differences between the number of nursing and BBM students who agreed with statements posed by the questionnaires, e.g., that they would move out of their community if a mental health facility was established there (χ2=16.503, p<0.002), that they were not afraid of treated mentally ill people (χ2=15.279, p<0.004), and that people with mental illness tend to be violent (χ2=14.215, p<0.007) and dangerous (χ2=17.808, p<0.001). Nursing students disagreed that people with mental illness are easily identified (χ2=30.094, p<0.000), have a lower IQ (χ2=70.689, p<0.000) and should not have children (χ2=24.531, p<0.000). Nursing students were more benevolent than BBM students, as they agreed that people with mental illness can hold a job (χ2=49.992, p<0.000) and can return to their former position (χ2=11.596, p<0.021), that everyone faces the possibility of becoming mentally ill (χ2=38.726, p<0.000), and that one should not laugh at the mentally ill (χ2=17.407, p<0.002). Nursing students held less pessimistic attitudes, as they felt that the mentally ill should receive the same pay for the same job (χ2=10.669, p<0.031) and that the public are prejudiced towards people with mental illness (χ2=17.604, p<0.001). Conclusion. College students’ attitudes towards people with mental illness vary based on the course that they are enrolled in. Attitudes may be positively improved by revising curriculum design to incorporate educational sessions about mental illness. These are essential steps to combat discrimination, and potentially enhance the promotion of human rights for the mentally ill

Mifepristone: an alternate to dinoprostone in induction of labour

Background: To assess and compare the efficacy, safety and fetomaternal outcome of mifepristone versus dinoprostone in priming the cervix and in inducing labour in pregnant women at term.Methods: This is a prospective comparative study done in Chettinad health and research institute, over a period of one year from October 2015 to October 2016. 50 pregnant women (Group 1) in 3rd trimester with unfavorable cervix were given 200mcg of mifepristone orally. If labour did not start or if the Bishop score remained poor at the end of 24hrs, induction was continued with 0.5mg of dinoprostone gel at a maximum of 3 gels at 6th hourly interval. Another 50 pregnant women (Group2) in 3rd trimester underwent induction according to the routine dinoprostone gel regimen of maximum 3 gels at intervals of 6hrs.Results: Improvement in Bishop score was significant with mifepristone by the end of 24hrs.But, in comparison, there was statistically significant improvement in Bishop score in favour of dinoprostone (Mean 4.7) than mifepristone (Mean 4.0). Also, the induction delivery interval was significantly less (Mean 11.5 hrs) with dinoprostone than mifepristone (Mean 20.3 hrs). Number of cases undergoing LSCS for failed induction was less in mifepristone group (4%). The rate of vaginal delivery, Caesarean sections, instrumental delivery and overall fetal outcome was comparable in both groups.Conclusions: Mifepristone is a safe, effective and suitable alternate agent for cervical ripening and initiation of labour when given 24 h before onset of labour.

Pirfenidone Induced Photosensitivity Reaction in a Patient with Idiopathic Pulmonary Fibrosis

Drug-induced photosensitivity refers to the development of cutaneous disease as a result of combined effects of a chemical and light. Photosensitivity reactions may result from systemic medications and topically applied compounds. Pirfenidone is known to cause photosensitivity reactions, rash, pruritus and dry skin at high doses. However, similar adverse reactions with low doses of Pirfenidone have not been reported. We report a case of photosensitivity reaction induced by low- dose Pirfenidone in a patient with idiopathic pulmonary fibrosis (IPF)

GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostrate cancer risk in south Indian men

The ethnic variation in the GGN and CAG microsatellites of the androgen receptor (AR) gene suggests their role in the substantial racial difference in prostate cancer risk. Hence, we performed a casecontrol study to assess whether GGN repeats independently or in combination with CAG repeats were associated with prostate cancer risk in South Indian men. The repeat lengths of the AR gene determined by Gene scan analysis, revealed that men with GGN repeats £21 had no significant risk compared to those with >21 repeats (OR 0.91 at 95% CI-0.52–1.58). However, when CAG repeats of our earlier study was combined with the GGN repeat data, the cases exhibited significantly higher frequency of the haplotypes CAG £19/GGN £21 (OR-5.2 at 95% CI-2.17– 12.48, P 21(OR-6.9 at 95%CI-2.85–17.01, P < 0.001) compared to the controls. No significant association was observed between GGN repeats and prostate-specific antigen levels and the age at diagnosis. Although a trend of short GGN repeats length in high-grade was observed, it was not significant (P = 0.09). Overall, our data reveals that specific GGN/CAG haplotypes (CAG £19/GGN £21 and CAG £19/GGN > 21) of AR gene increase the risk of prostate cancer and thus could serve as susceptibility marker for prostate cancer in South Indian men

Oral Juvenile Hyaline Fibromatosis: A Rare Entity

Juvenilna hijalina fibomatoza iznimno je rijedak poremećaj kod dojenčadi i djece, a javlja se prema zakonima autosomno recesivnog nasljeđivanja. Izgleda poput multiple kožne ili subkutane tumorne tvorbe, sporo se razvija i češća je u području glave i vrata te gornjeg dijela trupa. Često je povezana s gingivnom hipertrofijom, teškom fleksularnom kontrakturom udova i koštanom lezijom. Nema mentalne retardacije. Histološki se te lezije sastoje od obilne eozinofilne osnovne tvari s neravnomjerno raspršenim fibroblastima. Ekscidirane lezije u ranim stadijima bogatije su stanicama. Točno podrijetlo eozine hijaline tvari nije poznato. Nedavno je pronađen defekt kromosoma 4q21 povezan s lokusom gena – 2 za kapilarnu morfogenezu. Diferencijalna dijagnoza za juvenilnu hijalinu fibromatozu uključuje i infantilnu sistemsku hijalinozu, za koju se zna da je alelna. Trenutačno nema široko prihvaćene učinkovite terapije ni za juvenilnu hijalinu fibromatozu ni za infantilnu sistemsku hijalinozu. Juvenilna hijalina fibromatoza i infantilna sistemska hijalinoza ponekad se teško razlikuju jer su vrlo slične. Mi izvještavamo o slučaju juvenilne hijaline fibromatoze kod 10-godišnje djevojčice s pretežno gingivalnom hiperplazijom.Juvenile hyaline fibromatosis is an exceedingly rare disorder of infants and children which appears to have autosomal recessive inheritance. It is characterized by multiple, slowly growing dermal or subcutaneous tumors, especially in the head and neck region and upper trunk, often associated with gingival hypertrophy, severe flexural limb contractures and bone lesions. There is no mental retardation. Histologically, these lesions are composed of copious eosinophilic, homogenous ground substance with unevenly dispersed fibroblasts. Lesions excised in early stages are more cellular. The precise nature of the eosinophilic hyaline material is not known. Recently, a defect on chromosome 4q21 associated with the locus of the capillary morphogenesis gene – 2, has been demonstrated. The differential diagnosis of juvenile hyaline fibromatosis includes infantile systemic hyalinosis, which is now known to be allelic. Currently, no widely accepted effective treatment exists for juvenile hyaline fibromatosis or infantile systemic hyalinosis. Infantile systemic hyalinosis and juvenile hyaline fibromatosis are sometimes difficult to separate since they show significant overlap. We report one such unusual case of juvenile hyaline fibromatosis in a 10 year old female presenting mainly with gingival hyperplasia